The effect of Salvia officinalis hydroalcoholic extract on PTZ-induced seizure threshold in Vincristine injected mice

and Studies show that Vincristine is an anti-cancer drug which has neuropathic effects. Some studies have shown that Salvia officinalis has therapeutic effects on nervous system. The purpose of this study was to investigate the effects of Salvia officinalis hydroalcoholic extract and Vincristine on pentylenetetrazole (PTZ)-induced seizure threshould in mice. In this experimental study, 32 mice were randomly divided into 4 groups. The first group received normal saline, second group received Salvia officinalis hydroalcoholic extract (1 g/kg, i.p.), third group received Vincristine (10 µg/kg/day, i.v.) and finally the fourth group received hydroalcoholic extract of Salvia officinalis plus Vincristine. Then the seizure threshold was determined for each group after the injections. The data were analyzed using one way ANOVA followed by Tukey test. The results of this study showed that hydroalcoholic extract of Salvia officinalis significantly increased the PTZ Induced seizure threshold (P<0.05). Simultaneous uses of Vincristine and Salvia officinalis extract caused a significant increase in seizure threshold in Vincristine group (P<0.05). Considering the existence of different types of ingredients in Salvia officinalis extract; such as antioxidants, b-pinene and spathulenol, which have beneficial affects on the nervous system as well as their antioxidant effects, we can use this plant to reduce Vincristine induced neuropathic effects.