Myocardial inflammation and damage induced by lead pollution - the role of restrain regular aerobic training

Cardiovascular disease is main cause mortality in world; that is associated with inflammation and oxidative stress. Lead is a common environmental toxin that long history of known toxicity in impact organs with low antioxidant defense such as heart. Therefore, the purpose of this study was to study effects of exercise training on myocardial inflammation and damage induced by lead acetate in male rats. Twenty-six male rats (Two months of age and Mean body weight of 219±10 g), were randomly divided into three groups include; the Base, lead and aerobic exercise + lead. The rats in the exercise group performed the progressive treadmill running of 15 to 22 m/min for 25 to 64 min, 5 times a week for 8 weeks. Lead and aerobic exercise + lead groups received lead acetate (20 mg/kg) into intra-peritoneal, 3 times a week for 8 weeks. As well as sham group received same amount salin solution. HS-CRP and CPK-MB as index of myocardial inflammation and damage was determined in cardiac tissue and serum by Immunoturbidimetric and ELISA methods, respectively and also MDA and GPx as index of oxidant and antioxidant was measured in serum and heart tissue by Thiobarbituric acid reactive substances and method described by Kalpana methods and then Examination of the data by one- way ANOVA (p<0.05). Results indicated that Injection of lead acetate into intra-peritoneal resulted in significantly increase the CPK-MB and MDA in serum and hs-CRP levels of cardiac tissue and significantly decrease the GPx levels in cardiac tissue (P<0.001). Also, administration aerobic exercise resulted in significantly decrease MDA and CPK-MB levels in serum and nonsignificantly decrease HS-CRP levels (respectively P< 0.01, P<0.001, P<0.086) and significantly increase GPx levels (P<0.001) of cardiac tissue in aerobic exercise + lead group in compared by lead group. Overall, results from the present study significant the role of restrain regular aerobic training on process of inflammation and oxidant and therefore cardiac damage in subjects that exposed to chronic pollution induced by lead acetate.