Logistic Regression Model for Prediction Airway Reversibility Using Peak Expiratory Flow
Author(s):
Abstract:
Background
Using peak expiratory flow (PEF) as an alternative to spirometry parameters (FEV1 and FVC), for detection of airway reversibility in diseases with airflow limitation is challenging. We developed logistic regression (LR) model to discriminate bronchodilator responsiveness (BDR) and then compared the results of models with a performance of >18%, >20%, and >22% increase in ΔPEF% (PEF change relative to baseline), as a predictor for bronchodilator responsiveness (BDR). Materials And Methods
PEF measurements of pre-bronchodilator, post-bronchodilator and ΔPEF% of 90 patients with asthma (44) and chronic obstructive pulmonary disease (46) were used as inputs of model and the output was presence or absence of the BDR. Results
Although ΔPEF% was a poor discriminator, LR model could improve the accuracy of BDR. Sensitivity, specificity, positive predictive value, and negative predictive value of LR were 68.89%, 67.27%, 71.43%, and 78.72%, respectively. Conclusion
The LR is a reliable method that can be used clinically to predict BDR based on PEF measurements.Language:
English
Published:
Tanaffos Respiration Journal, Volume:11 Issue: 1, Winter 2012
Page:
49
https://magiran.com/p968292
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