Analysis of Ovarian Epithelial Tumors for Presence of Human Papillomavirus

Background and Ôvarian tumour is a common neoplasm of the female genital tract and one of the most lethal gynecologic malignancies. The aetiology of ovarian cancer remains unclear. Ôncogenic viruses can contribute to different steps of the carcinogenic process. Papillomaviruses are Ôncogenic virus that can be induce proliferation of epithelial cells. Ïn this study, were selected Paraffin-embedded blokes from 50 female patients with ovarian carcinoma and 58 ovarian tissues (without malignancy) as a control. Âfter DNÂ extraction, Âll samples were analyzed for the presence of beta globin gene and suitable samples were screened for existence of L1 HPV-Çommon. Âll samples that were positive for beta globin gene, to amplify by HPV-common primers. 7 out of 44 (15.90%) Ôvarian carcinoma and 5 out of 50 (10%) ovarian tissue were positive for the common marker of HPV. Ïn overall samples, 12 out of 94 (12.76%) samples were positive. Statistically, the correlation between HPV infection and ovarian cancer (P = 0.397) wasn’t significant. Çonclusion: No significant correlation between HPV infection and ovarian cancer was found (P>0.05).Ôur data couldn’t confirm a role of HPV in ovarian cancer.