Malicious behaviors, which are rapidly increasing in the modern era, will have irreparable negative consequences for organizations, so it has attracted researchers' attention in recent decades. In this regard, the present study was conducted to identify the factors that cause destructive behaviors of staff at Payam Noor University of Karaj. This study is a descriptive survey in terms of purpose and method of data collection. In addition, the present study has been analyzed using a qualitative-quantitative research methodology. In the first stage, to identify the factors causing malicious behaviors, interviewing 10 professors, faculty members and experts in the field of face-to-face behavior. A qualitative content analysis method was used and a questionnaire was designed based on quantitative research. The statistical population of the study consisted of 245 employees of Payam-e-Noor University of Alborz. The sample size was 150 individuals using Cochran formula. The instrument for collecting data was standard questionnaire. The reliability of these questionnaires was confirmed by Cronbach's alpha coefficient of 0.91. Structural equation modeling software was used to analyze the collected data. The results indicate that emotional intelligence and leader-member interaction have the opposite effect on malicious behaviors, and in contrast to injustice, stress, and personality traits include introversion, disagreement, lack of conscientiousness, neuroticism, and inattention. Experience openness has a direct impact on destructive behaviors.