Soil erosion is an important economical, social and environmental problem requiring intensive watershed management for its control. In recent years, modeling has become a useful approach for assessing the impact of various erosion-reduction approaches. Due to limited hydrologic data in mountainous watersheds, watershed modeling is, however, subject to large uncertainties. In this study, SWAT2000 was applied to simulate runoff and sediment discharge in Beheshtabad watershed, a sub-basin of Northern Karun catchment in central Iran, with an area of 3860 km2. Model calibration and uncertainty analysis were performed with SUFI-2. Four indices were used to assess the goodness of calibration, viz., P-factor, d-factor, R2 and Nash-Sutcliffe (NS). Runoff data (1996-2004) of six hydrometery stations were used for calibration and validation of this watershed. The results of monthly calibration p-factor, d-factor, R2 and NS values for runoff at the watershed outlet were 0.61, 0.48, 0.85 and 0.75, respectively, and for the validation, these statistics were 0.53, 0.38, 0.85 and 0.57, respectively. The values for calibration of sediment concentration at the watershed outlet were 0.55, 0.41, 0.55 and 0.52, respectively, and for the validation, these statistics were 0.69, 0.29, 0.60 and 0.27, respectively. In general, SWAT simulated runoff much better than sediment. Weak simulation of runoff at some months of the year might be due to under-prediction of snowmelt in this mountainous watershed, model’s assumptions in frozen and saturated soil layers, and lack of sufficient data. Improper simulation of sediment load could be attributed to weak simulation of runoff, insufficient data and periodicity of sediment data.