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| Functional and Physical Consequence of Human Immunodefficiency Virus Transactivator TAT Interaction with Human Cell Cycle Regulator p53 | |
| Author(s): | Janet Duvall، Fatah Kashanchi |
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Abstract: |
Human immunodeficiency virus (HIV) transactivator Tat is a potent activator of both viral and cellular genes. Tat has also been implicated in the development of AIDS-related malignancy. Here, we show that Tat physically and functionally is able to sequester the cell cycle check point protein p53. This sequestration results in non-functional promoter activity of cyclin-dependent kinase/cyclin inhibitor, namely p21 (Waf1). Therefore, it is proposed that a Tat/p53 complex in vivo may deregulate p53 responsive genes, hence allowing for deregulation of check point, which may lead to development of malignancies. |
| Keywords: | HIV، TAT، Transcription، Cell cycle، p53 |
| Language: | English |
| Published: | Iranian Biomedical Journal, Volume:1 Issue: 1, Jan 1997 |
| Page: | 1 |
| Full text: | PDF is available on the website. |