Non-alcoholic fatty liver disease (NAFLD) is the most common chronic liver disease in the world which is associated with cardiovascular disease. The aim of this study was to investigate the plasma changes of chemerin and pentraxin-3 (PTX3) following 8 weeks of endurance training in men with NAFLD.
In this quasi-experimental Study, thirty four patients with NAFLD were selected purposefully. The participants were randomly divided into two groups, endurance training group (n=17) and control group (n=17). The endurance training program included eight weeks running on a treadmill with maximum heart rate (HRmax) intensity of 55-75% for 45 minutes three times a week. Seventy two hours before the beginning of the study and at the end of the eighth week, blood samples were taken from all the participants. The data were analyzed by paired sample t-test and independent t-test at the significant level p Plasma levels of chemerin in the endurance training group significantly decreased (p=0.013). Also, there was a significant difference between the two groups after the end of the intervention (p=0.002). Plasma levels of PTX3 increased significantly in the endurance training group (p=0.001). There was also a significant difference between two groups after the end of the intervention (p=0.01).
The present study showed that the 8-week endurance training increased the plasma levels of PTX3 and decreased the plasma levels of chemerin in men with NAFLD. Endurance training, possibly through various mechanisms, reduces the inflammatory factors and increases the anti-inflammatory factors in men with NAFLD. Endurance training, probably by activation of lipolysis, over-regulation of unpaired protein-1 and activator receptors of peroxisomes proliferation-, changes in adipocytokines, etc. decreases charmicin and increases PTX3 levels of plasma in men with NAFLD.

Non-alcoholic fatty liver disease is a public health problem in the world. Exercise is a first-line therapy for patients with non-alcoholic fatty liver disease. Therefore, the present study was conducted to determine the effect of eight weeks of endurance training on serum levels of alanine aminotransferase, aspartate aminotransferase, and resistin in men with non-alcoholic fatty liver disease. A total of 23 patients with non-alcoholic fatty liver disease were selected following purposeful sampling in the present quasiexperimental study. Participants were randomly divided into two groups: endurance training group (n=12) and control group (n=11). The endurance training program included moderate intensity training with 60-75% of maximal heart rate for 45 min/session, 3 times/week for 8 weeks. At both baseline and completion of the eighth week, blood samples were obtained from all the participants. Data were analyzed running Shapiro-Wilk test and dependent and independent t-tests at the significant level of p In the current study, eight weeks of endurance training resulted in a significant decrease in serum levels of alanine aminotransferase, aspartate aminotransferase, and resistin in males with non-alcoholic fatty liver(α<0.05). According to the findings, endurance training may improve the serum levels of alanine aminotransferase, aspartate aminotransferase, and resistin in men with non-alcoholic fatty liver disease. Therefore, to reduce the dependent risk factors of non-alcoholic fatty liver disease, this therapeutic intervention seems to be beneficial.

Over the past two decades, non-alcoholic fatty liver disease (NAFLD) has progressed from a relatively unknown disease to one of the leading causes of chronic liver disease with an increasing prevalence that can lead to cirrhosis and liver failure. Due to the obesity prevalence and the increasing prevalence of metabolic syndrome, non-alcoholic fatty liver and its progressive form, Non - Alcoholic Steatohepatitis (NASH), is more common in different parts of the world. However, there is no exact and non-invasive way to diagnose this disease. It is estimated that the obesity prevalence will continue to exacerbate non-alcoholic fatty liver prevalence and its long-term complications, leading to enormous clinical and economic burdens. This article reviews the epidemiology of non-alcoholic fatty liver disease in Iran and the world and related risk factors. Google Scholar and PubMed databases were used to identify studies on the epidemiology of non-alcoholic fatty liver worldwide.

During recent decades exercise has emerged as a key adjuvant tool in the control of many diseases, including non-alcoholic fatty liver diseases (NAFLD). In addition, studies have demonstrated that different training protocols were effective in reducing the prevalence of the disorder and improving some liver metabolic functions. The purpose of this review was to summarize and analyze articles about the effects of aerobic and resistance training on insulin resistance and some biomarkers in NAFLD.
The PubMed, Medline, Irandoc, SID, Google Scholar and Magiran databases were searched for the physiological effects of two types of training) aerobic and resistance( on NAFLD. Totally, among the 300 articles reviewed, 107 ones were selected for later consideration.
Although through different mechanisms, the non-alcoholic fatty liver patients can benefit from both types of aerobic and resistance training.
Regardless of the type of training, on engaging in regular physical activity the non-alcoholic fatty liver patients may effectively control and improve the emerging inflammatory processes, obesity and insulin resistance.

Identification of the factors related to non-alcoholic fatty liver disease in children and adolescents help us to know appropriate methods for prevention and control of chronic diseases. This cross-sectional and analytic study comprised 962 children and adolescents, aged 6-18 years, in Isfahan in 2008. Variables related to life style and metabolic syndromes related were determined and their relationship with non-alcohlic fatty liver disease were analysed using Least Absolute Shrinkage and Selection Operator (LASSO) regression method, using SPSS. The final obtained model with the omission of 13 low effect variables had 5 powerful and effective variables in which oil consumption, waist circumference, body mass index and blood cholesterol level are factors that increase the probability of nonalcoholic fatty liver disease. The age variable is an ablative variable with negative coefficient in the final model. The relationship between body mass index as well as waist circumference with nonalcoholic fatty liver were statistically significant (P)

Nonalcoholic fatty liver disease (NAFLD) is one of the most common liver disease. It occurs most commonly among obese and overweight people. This study was performed to determine the effect of nutrition education on anthropometric indices, biochemical and sonographic findings in patients with NAFLD Referring to Khuzestan Diet Therapy clinic, Academic Center for Education, Culture and Research (ACECR), Branch of Khuzestan, in Ahvaz, Iran.
This study was a before and after interventional study carried out on 30 NAFLD patients. Selected variables were evaluated at the time before and after three month intervention by nutrition education for patients. SPSS 19 and statistical tests, including descriptive, paired samples t-test and non-parametric sign test was used to analysis the data.
The average age of the patients were 44.8 ± 11.2 years. Anthropometric indices decreased significantly after three months nutrition education intervention (p Nutrition education could affect the anthropometric and biochemical indices and improve the liver function of NAFLD patients.

Non-alcoholic fatty liver disease is the most common hepatic disorder in industrial societies with a prevalence ranging within 15-35% in the European and Middle Eastern populations. This disease is one of the most important causes of mortality due to hepatic diseases. Regarding this, the aim of the present study was to investigate the effect of a six-week combined aerobic and resistance training on some liver function parameters in the middle-aged men with non-alcoholic fatty liver disease.
This quasi-experimental study was conducted on 16 middle-aged men with non-alcoholic fatty liver disease (mean age: 36.62±6.5 years, weight: 85.48±5.43 kg, body mass index [BMI]: 28.75±1.30 kg/m2). The study population was randomly assigned into two groups of exercise training and control. The exercise training group was subjected to six weeks of combined aerobic and resistance training performed three sessions a week. Body weight, BMI, aspartate aminotransferase (AST) level, alanine aminotransferase (ALT) level, liver ultrasound parameters, peak oxygen uptake (VO2 max), waist-hip ratio, and body fat percentage were assessed before the intervention and six weeks post-intervention. The data were analyzed using one-way analysis of covariance.
In the exercise group, despite observing no significant changes in the ALT and liver ultrasound parameters, there were significant improvements in the body weight, BMI, AST, VO2 max, waist-hip ratio, and body fat percentage after six weeks of exercise training (P As the findings of the present study indicated, a six-week exercise training by improving some liver enzymes and body composition probably can be an appropriate treatment for non-alcoholic fatty liver disease in the middle-age men.

Lipid accumulation in the liver is associated with non-alcoholic fatty liver disease (NAFLD), with obesity and insulin resistance being the main contributing factors. The AMPK/SIRT1 signaling pathway plays a crucial role in addressing lipid metabolism issues. Recent studies have demonstrated that the AMPK/SIRT1 signaling axis is involved in preventing and reducing liver damage. Upregulation of AMPK/SIRT1 can regulate lipid metabolism and oxidation in liver cells. In NAFLD, increased activity of AMPK/SIRT1 can inhibit the synthesis of fatty acids and cholesterol by down-regulating adipogenesis genes (FAS, SREBP-1c, ACC, and HMGCR). Therefore, activation of the AMPK/SIRT1 signaling pathway represents a potential therapeutic target for liver disorders. This review summarizes the most recent studies on the AMPK/SIRT1 pathway signaling axis and the mechanisms of herbal activators of the AMPK/SIRT1 pathway in non-alcoholic fatty liver

Nonalcoholic fatty liver disease (NAFLD) represents a spectrum of disorders characterized by predominantly macrovesicular hepatic steatosis that occur in individuals even in the absence of consumption of alcohol in amounts considered harmful to the liver. At present, there is no standard recommended treatment for NAFLD. Treatment currently focuses on gradual weight loss through diet and regular exercise. Insulin sensitizers such as thiazolidinediones and metformin show promise, and several studies have explored the role of lipid lowering agents and antioxidants. Coenzyme Q10 (CoQ) is a powerful antioxidant and has an important role in respiratory metabolism, as a mobile electron and proton carrier in the mitochondrial electron transport chain. However, to date, there is no published clinical trial on CoQ in NAFLD. We postulate the hypothesis that CoQ might be effective in the treatment of NAFLD.

vThe prevalence of obesity and its complications, including deaths, are increasing worldwide. obesity is one of the most important causes of non- alcoholic fatty liver disease. This disease is the most common liver disorder caused by excessive deposition of fatty acids and triglycerides. In fatt tissue, a number of proteins called adipokines are secreted, which have different pro- inflammatory or anti – inflammatory effects. Adipokines play an important role in chronic or acute liver diseases. Studies have shown that adipokines play a role in the pathogenesis of NAFLD and its progression to NASH. Probiotics are microorganisms that can increase the number of beneficial gut bacteria  and improve fat metabolism. Probiotics reduce the level of liver enzymes (aspartate aminotransferase, alanine aminotransferase and gamma glutamyl transferase) and inflammatory factors such as TNF-α, IL-6 and improve liver function. The results show that probiotics and adipokines can be used in the diagnosis and treatment of non-alcoholic fatty liver disease.