Aim and Gastric cancer is the fourth most common cancer and second leading cause of cancer related death in the world. Survivin gene encodes a protein which is one of the apoptosis inhibitors. It plays an important role in maintaining the gastric mucosa and is vital for normal function of the stomach. It also plays a key role in differentiation of gastric the epithelial cells and repairs the gastric mucosa after damage. This gene is widely expressed in the gastric stomach, its expression increase significantly in gastric cancer. Regarding role of survivin gene in gastric cancer, in the present study, the association of single- nucleotide polymorphism (rs2071214) A9194G in exon 4 survivin gene with risk of gastric cancers is investigated.
Material and In this study, 101 patients with gastric cancer and 101 healthy subjects as the control (all matched in terms of age and gender) were examined by PCR-RFLP technique. The obtained data and information were analyzed by statistical regression logestic and 2 testes.
The results of this study showed that different genotypes of polymorphism A9194G and alleles are not significantly associated with gastric cancer.
Our results have shown that there isn’t an association between A9194G polymorphism with the risk of gastric cancer.

Gastric cancer is the most common gastrointestinal cancer and the third leading cause of death in men and the third most common cancer among women in the past two decades in Iran. Analysis the effective related agents can resulted in performance the health system in order to reduce the risk of this disease and help improve the public health. This study due to the difference in various regions, try to discover the spatial trend of Stomach cancer, and to identify critical areas in Metropolitan Tehran, Local Moran autocorrelation index taking into account the different levels of gastric cancer in Tehran. The results showed the High risk of stomach cancer in South and central regions of Tehran that suffering higher levels of pollution in water and air.

Gastric cancer is the most prevalent cancer with poor survival in gastrointestinal tract. Caspase 3 and 9 play an important role in the development and progression of cancer. Polymorphisms in the genes for these enzymes can affect gene activity and thus may influence susceptibility to gastric cancer. In this study، caspase 3 and 9 genes polymorphisms in patients with gastric cancer were examined. In a case - control study، 100 patients with gastric cancer and 100 healthy individuals were evaluated in the region rs4647601: G> T for caspase-3 and -1263 A> G gene promoter for caspase 9. DNA extraction was performed from whole blood according to manufacture protocol. RFLP-PCR method was carrying out for detection of caspase 3 and 9 genes genotype in two groups. In this study، 143 men and 57 women were evaluated. All of them were selected from the same race and geographical area. The results indicated an increase of the mutant G allele in the control group، which leads to a decreasing in the incidence of gastric cancer (P<0. 0001، OR: 0. 096، (%0. 95CL) =0. 04-0. 23). It seems that screening of -1263 A> caspase 9 polymorphism could be a useful marker in personal sensitivity to gastric cancer and help to cancer treatment and prevention process. It is concluded that caspase gene variation may be a diagnostic factor in the gastric cancer.

Background and Gastric cancer is the fourth most common cancer and the second leading cause of cancer death worldwide. North of Iran is a high risk area for gastric cancer. Bcl2 family is the most important regulator of apoptosis and -938C>A single nucleotide polymorphism of bcl2 gene promoter has been demonstrated to influence gastric cancer susceptibility. In this research we studied the effect of -938C>A genotype on gastric cancer.
This analysis was performed in 87 patients with gastric cancer who underwent surgery in Mazandaran and Golestan province along with 104 healthy individuals as controls. DNA extracted from peripheral blood samples was applied in PCR-SSCP (Polymerase chain reaction-single strand conformation polymorphism) analysis to determine -938C>A genotype. The association of the -938C>A genotype and gastric cancer risk as well as demographic and clinicopathological characteristics were analyzed by logistic regression method.
Frequency of AA, CC and AC genotypes in cases were 13.79, 16.09 and 70.12% and 15.38, 23.08, and 61.54% in control group, respectively. Statistical analysis indicated that the AC genotype was significantly (P=0.0009) associated with a decreased risk for gastric cancer by 0.2 fold (OR=0.276) compared with the combined genotype of AA. No significant association was found between -938C>A genotype with demographic and clinicopathological characteristics.
The study showed that the presence of AC genotype may decrease the risk of gastric cancer. So, investigating the -938 C>A single nucleotide polymorphism of bcl2 gene promoter could be an appropriate molecular marker that could be used to determine individual sensitivity to gastric cancer and also for designing cancer prevention programs.

Gastric cancer is the most common cancers worldwide. The survivin gene which encodes an apoptosis protein inhibitor plays an important role in maintenance and integrity of the gastric mucosa. The gene is necessary for the normal physiologic function of the stomach, but its expression increases in gastric cancer. Regarding with the role of polymorphisms of the promoter region in genes expression, this study was done to determine the association of single- nucleotide polymorphism (rs9904341) -31C/G in promoter survivin gene with risk of gastric cancers.
In this case-control study, 101 patients with gastric cancer and 101 matched age and gender healthy subjects as the control were examined by PCR-RFLP technique.
Genotype CC was significantly increased the risk of gastric cancer up to 2.4 folds (95% CI=1.03–5.61, P This study showed that single- nucleotide polymorphism (rs9904341) -31C/G in promoter survivin gene significantly increase the risk of gastric cancers.

Though increased risk of gastric cancer in individuals with family history of the disease has been observed consistently in previous studies, data on the association between gastric cancer and family history of cancer from Iran is scanty. The purpose of this study is to evaluation of gastric cancer risk associated with family history cancer. The present study was designed as unmatched case-control study. Cases were 746 histopathologically confirmed gastric cancer and 746 controls were randomly selected among the healthy participants in a health survey. The family history of cancer was extracted from a standard history form completed by the patients or health care providers. Mantel-Heanszel Odds Ratio was computed for removing the confounding effect of age and sex. A positive family history of cancer was reported by 9.7% and 5.6% of cases and controls, respectively. Gastric cancer risk increased two-fold for subjects reporting any first degree relative with gastric cancer. There is no statistical association among family history of other cancers and gastric cancer (P>0.05). In conclusion, this study showed that family history of gastric cancer, especially in first-degree relatives, increases the risk of gastric cancer. Further studies are needed to better understand the role of genetic factors and environmental factors and their interaction in gastric cancer development in Iranian community.

Several different factors play role in developing gastric and colon cancers including infectious agents. Since there is no study about association of human T-lymphotropic virus 1 (HTLV-1) with cancers of digestive organ yet, so this study was performed to investigate the frequency of this infection in patients infected with gastric and colorectal cancers. This project was performed as a case-control study between years 2009 to 2012. Two hundred and sixty five patients were cases of gastric and colorectal cancer confirmed by pathology and 244 healthy subjects were those who underwent endoscopy and colonoscopy and shown no sign of abnormality. We used third generation ELISA on sera of these people to assess their anti-HTLV-1 antibody status. Two hundred and one GC patients, 64 CRC patients and 244 control subjects were enrolled in this study. Mean age of GC patients in the time of diagnosis was 59.24±12.50 years, CRC patients 58.98±13.39 and control subjects 57.83±11.25 years. One GC patient was positive for HTLV-1 antibody, no CRC patient was positive, while 4 control subjects had antibody against HTLV-1. There was no significant relationship between antibody positivity and gastric cancer or colorectal cancer. On the basis of current study, even though the rate of infection with this virus in GC patients was lower than control subjects.

Gastric cancer is the fourth most common cancer and is the second cause of death from cancer. Although the Helicobacter pylori infection is a very important factor in gastric cancer، it is not the only risk factor. The role of nutrition has been studied as the most important environmental risk factors in incidence، control and prevention of gastric cancer. This study aimed to review past researches on the association between several dietary factors and gastric cancer. A literature search in PubMed was done with the use of «Gastric cancer»، «Helicobacter pylori»، «Fruit and vegetables»، «Meat and processed meat»، «Salt and salted food»، «Green tea»، «Black tea» and «Coffee» as keywords. Findings from 36 cross-sectional، ecologic، case-control، cohort، and meta-analysis studies، until 2011، have been taken into account in this review. Findings from the current evidence suggest that the risk of gastric cancer decreases with high intake of fruits and fresh vegetables and possibly with green tea consumption، and increases with the intake of various processed meats، salt and salted foods. There is no clear evidence about the relationship between gastric cancer and various meats، fish، black tea and coffee. Dietary modification to increase intake of fruits and fresh vegetables and to reduce intake of salt and salted foods، represent an effective strategy in control and prevention of gastric cancer.

Cytochrome P450 2E1 (CYP2E1) enzyme metabolically activates a large number of low molecular mass xenobiotics probably involved in gastric cancer incidence through activation of procarcinogens. North of Iran is amongst high incidence rate areas of gastric carcinoma where environmental carcinogenic compounds, including agricultural pesticides, are massively used. In this report, we quantitatively compared CYP2E1 gene expression between tumoral and nontumoral-marginal tissues of gastric cancer patients as well as normal healthy gastric tissues by real-time PCR. Results showed that CYP2E1 gene cDNA copy numbers were relatively increased in tumoral group vs. nontumoral-marginal and normal healthy groups. Comparison of means DDCT by Dunkan’s test statistically verified significant differences of cyp2E1 cDNA copy numbers between tumoral and healthy tissues (P=0.0018). It seems that the increased CYP2E1 gene expression may be associated with increased risk for gastric cancer. So, we recommended that CYP2E1 gene expression may be an appropriate molecular marker to determine individual sensitivity to gastric cancer and also for designing cancer prevention programs.

Gastric cancer remains as a chronic disease with a high rate of morbidity and mortality around the world. This study was done to systematically review and meta-analysis the current evidence on the association between vitamin D intake as well as serum 25-hydroxy vitamin D levels and risk of gastric cancer.

Published evidence in this area was searched to December 2012 through the use of ISI Web of Science, Scopus, PubMed/Medline, Ovid database, EMBASE and Google scholar for relevant articles by cross-referencing. Out of 132 retrieved papers in our search, 7 articles had reported odds ratios or relative risks as their effect size. Statistical analyses were conducted by using Stata version 11.2 the existence of between-study heterogeneity and publication bias was examined.

Based on the pooled effect size, the odds ratio (95% confidence interval) for comparison of highest versus lowest intakes of vitamin D was 1.09 (0.94, 1.25; P=0.26) also for highest versus lowest serum vitamin D levels was 0.92 (0.74, 1.14; P=0.429) indicating no significant association between vitamin D intake or serum 25-hydroxy vitamin D levels and risk of gastric cancer; There was no evidence for between study heterogeneity.

we found no evidence for thesignificant association between vitamin D status and risk of gastric cancer.