Non alcoholic fatty liver disease is a common disease with an increased risk of atherosclerotic changes of the vascular structures، which could lead to vascular disease. T his study has been carried out to evaluate the significant relation ship among non alcoholic fatty liver disease and hemodynamic criterion of the intracranial vessels by transcranial doppler ultrasound as a non invasive method. Matrials and In this cross sectional study، involving 47 subjects ages 23 to 68، who had been evaluated for hemodynamic criterion of the intracranial vessels by transcranial doppler ultrasound were studied. Subjects were divided based on the ultrasound criterion for fatty liver disease as follows: mild (10 patients)، moderate (10 patients) and severe (11 patients). ANOVA and K2 were used to analyze the data. The results indicated that the hemodynamic criterion of intracranial cerebral vessels، pulsatility index (PI) and resistance index (RI) in anterior، middle and posterior cerebral arteries and internal carotid arteries in severe non alcoholic fatty liver group were significantly higher as compared to control group (p<0. 05). There was a significant increased in these hemodynamic criterion values in middle cerebral arteries in non alcoholic moderate fatty liver group as compared to the control group (p<0. 05). Increase in the values of pulsatility index (PI) and resistance index (RI) of the intracranial cerebral vessels in moderate and severe non alcoholic fatty liver groups could be related to atherosclerotic changes of the intracranial vessels owing to malfunction of the cellular endothelium secondary to non alcoholic fatty liver disease as part of the metabolic syndrom، emphysis the significance control of the atherosclerotic risk factors and early prevention and treatment of intracranial vessels disease to reduce complications of the non alcoholic fatty liver disease.

Over the past two decades, non-alcoholic fatty liver disease (NAFLD) has progressed from a relatively unknown disease to one of the leading causes of chronic liver disease with an increasing prevalence that can lead to cirrhosis and liver failure. Due to the obesity prevalence and the increasing prevalence of metabolic syndrome, non-alcoholic fatty liver and its progressive form, Non - Alcoholic Steatohepatitis (NASH), is more common in different parts of the world. However, there is no exact and non-invasive way to diagnose this disease. It is estimated that the obesity prevalence will continue to exacerbate non-alcoholic fatty liver prevalence and its long-term complications, leading to enormous clinical and economic burdens. This article reviews the epidemiology of non-alcoholic fatty liver disease in Iran and the world and related risk factors. Google Scholar and PubMed databases were used to identify studies on the epidemiology of non-alcoholic fatty liver worldwide.

Non-Alcoholic Fatty Liver (NAFLD) is produced by liver pathological accumulation of fat and the prevalence of this disorder in the world is 35-36%. Evidence has shown that auxiliary treatments, including the use of antioxidant compounds, can be effective in improving non-alcoholic fatty liver. Resveratrol is a polyphenolic compound that has antioxidant properties. Other mechanisms of resveratrol have been shown to improve fatty liver.Study Type: A systematic Review on Randomized Clinical Trials.This study aimed to investigate the results of research on the relationship between supplementation of resveratrol and non-alcoholic fatty liver. Randomized Clinical Trials on the effect of supplementation of resveratrol on NAFLD from PubMed, Scopus, ISI and Google Scholar databases between 2000 and 2018 with the keywords: Resveratrol, Fatty Liver, Nonalcoholic Fatty Liver Disease, Nonalcoholic Steatohepatitis, NAFLD Reviewed. Between most clinical trials have shown positive effects of resveratrol supplementation on the improvement of non-alcoholic fatty liver symptoms, including oxidative stress, inflammation, liver enzymes, and insulin resistance. There was also a decrease in fat content in the subjects. However, some studies have different results and do not show a significant effect on resveratrol supplementation.n most studies, the positive effects of resveratrol supplementation on non-alcoholic fatty liver have been proven, but more studies are needed because of the controversy of the study.

During recent decades exercise has emerged as a key adjuvant tool in the control of many diseases, including non-alcoholic fatty liver diseases (NAFLD). In addition, studies have demonstrated that different training protocols were effective in reducing the prevalence of the disorder and improving some liver metabolic functions. The purpose of this review was to summarize and analyze articles about the effects of aerobic and resistance training on insulin resistance and some biomarkers in NAFLD.
The PubMed, Medline, Irandoc, SID, Google Scholar and Magiran databases were searched for the physiological effects of two types of training) aerobic and resistance( on NAFLD. Totally, among the 300 articles reviewed, 107 ones were selected for later consideration.
Although through different mechanisms, the non-alcoholic fatty liver patients can benefit from both types of aerobic and resistance training.
Regardless of the type of training, on engaging in regular physical activity the non-alcoholic fatty liver patients may effectively control and improve the emerging inflammatory processes, obesity and insulin resistance.

Non-alcoholic fatty liver disease (NAFLD) is the most common chronic liver disease in the world which is associated with cardiovascular disease. The aim of this study was to investigate the plasma changes of chemerin and pentraxin-3 (PTX3) following 8 weeks of endurance training in men with NAFLD.
In this quasi-experimental Study, thirty four patients with NAFLD were selected purposefully. The participants were randomly divided into two groups, endurance training group (n=17) and control group (n=17). The endurance training program included eight weeks running on a treadmill with maximum heart rate (HRmax) intensity of 55-75% for 45 minutes three times a week. Seventy two hours before the beginning of the study and at the end of the eighth week, blood samples were taken from all the participants. The data were analyzed by paired sample t-test and independent t-test at the significant level p Plasma levels of chemerin in the endurance training group significantly decreased (p=0.013). Also, there was a significant difference between the two groups after the end of the intervention (p=0.002). Plasma levels of PTX3 increased significantly in the endurance training group (p=0.001). There was also a significant difference between two groups after the end of the intervention (p=0.01).
The present study showed that the 8-week endurance training increased the plasma levels of PTX3 and decreased the plasma levels of chemerin in men with NAFLD. Endurance training, possibly through various mechanisms, reduces the inflammatory factors and increases the anti-inflammatory factors in men with NAFLD. Endurance training, probably by activation of lipolysis, over-regulation of unpaired protein-1 and activator receptors of peroxisomes proliferation-, changes in adipocytokines, etc. decreases charmicin and increases PTX3 levels of plasma in men with NAFLD.

Identification of the factors related to non-alcoholic fatty liver disease in children and adolescents help us to know appropriate methods for prevention and control of chronic diseases. This cross-sectional and analytic study comprised 962 children and adolescents, aged 6-18 years, in Isfahan in 2008. Variables related to life style and metabolic syndromes related were determined and their relationship with non-alcohlic fatty liver disease were analysed using Least Absolute Shrinkage and Selection Operator (LASSO) regression method, using SPSS. The final obtained model with the omission of 13 low effect variables had 5 powerful and effective variables in which oil consumption, waist circumference, body mass index and blood cholesterol level are factors that increase the probability of nonalcoholic fatty liver disease. The age variable is an ablative variable with negative coefficient in the final model. The relationship between body mass index as well as waist circumference with nonalcoholic fatty liver were statistically significant (P)

Non-alcoholic fatty liver disease is a public health problem in the world. Exercise is a first-line therapy for patients with non-alcoholic fatty liver disease. Therefore, the present study was conducted to determine the effect of eight weeks of endurance training on serum levels of alanine aminotransferase, aspartate aminotransferase, and resistin in men with non-alcoholic fatty liver disease. A total of 23 patients with non-alcoholic fatty liver disease were selected following purposeful sampling in the present quasiexperimental study. Participants were randomly divided into two groups: endurance training group (n=12) and control group (n=11). The endurance training program included moderate intensity training with 60-75% of maximal heart rate for 45 min/session, 3 times/week for 8 weeks. At both baseline and completion of the eighth week, blood samples were obtained from all the participants. Data were analyzed running Shapiro-Wilk test and dependent and independent t-tests at the significant level of p In the current study, eight weeks of endurance training resulted in a significant decrease in serum levels of alanine aminotransferase, aspartate aminotransferase, and resistin in males with non-alcoholic fatty liver(α<0.05). According to the findings, endurance training may improve the serum levels of alanine aminotransferase, aspartate aminotransferase, and resistin in men with non-alcoholic fatty liver disease. Therefore, to reduce the dependent risk factors of non-alcoholic fatty liver disease, this therapeutic intervention seems to be beneficial.

Nonalcoholic fatty liver disease (NAFLD) includes steatosis, nonalcoholic steatohepatitis, fibrosis and liver cirrhosis. The oxidative stress enzymes are the diagnostic markers to prediction of histologic status of liver in nonalcoholic steatohepatitis disease. The aim of the study was to assessment of relationship between serum Zinc (Zn) levels with pathologic manifestation in patients with nonalcoholic steatohepatitis.
This cohort study was done in patients with nonalcoholic steatohepatitis that had been visited in gastrointestinal clinic of Sina Hospital, Tehran, Iran from April, 2014 to April, 2015. Control group included the patients with no clinical manifestation of nonalcoholic steatohepatitis and normal liver ultrasonography, lab test and liver biopsy. Serum Zn level was measured with atomic absorption spectroscopy. Normal Serum level of Zn was considered 10.7-22.9 µmol/L (70-150 µg/dL) and less than 7 µg/dL was considered as Zn deficiency. Pathological findings were grading according to NAFLD activity score.
One hundred twenty patients were selected for the study in two equal groups. Six and 26 patients were excluded in case and control groups, respectively due to no consent to lab test. Finally, 54 patients (35 male/19 female) and 34 patients (22 male/12 female) in control group were participated in data analysis. The mean age on case and control group was 37.02±9.82 year and 33.24±12.01 year, respectively (P= 0.111). Zn level in case and control groups were 90.82±13.69 and 88.82±13.10, respectively. There were no statistically significant differences between two group in serum Zn level (P= 0.50). Also, there were no statistically significant differences between pathological grading in case group participants (steatosis: P= 0.640; Lobular inflammation: P= 0.882; fibrosis: P= 0.531).
The finding of the study showed no significant association between serum zinc level and hepatic steatosis, lobular inflammation and fibrosis of the liver in nonalcoholic steatohepatitis.

Despite the prevalence of nonalcoholic fatty liver disease in many countries still have not found a certain cure for it.
So the purpose of this study was to survey the effect of curcumin supplementation with resistance training in patients with non-alcoholic fatty liver disease.
In a randomized, controlled trial study, 45 patients with nonalcoholic fatty liver disease were divided into 4 groups (resistance training, curcumin supplement consumption, resistance training with curcumin supplement consumption, and placebo). The experimental groups performed a 12-week resistance training 3 days a week or consumed a curcumin capsule per day or both of them. Alanine aminotransferase (ALT), aspartate aminotransferase (AST), and alkaline phosphatase (ALP) levels before and after the protocol were measured. Data were analyzed by using ANCOVA with SPSS 22 software in P ALT and AST levels in resistance training and resistance training with curcumin supplement consumption significantly decreased (P0.05). The grade of liver fat in any groups did not change significantly (P>0.05).
On the basis of these results, we suggested that the Curcumin supplementation with resistance training in patient with nonalcoholic fatty liver disease could cause to improve liver function, but more studies must be conducted in this area with more subjects.

Menopause transition is accompanied with undesirable changes in body composition, fat distribution, increased visceral fat, and prevalence of nonalcoholic fatty liver disease. But limited studies have examined the effects of physical activity on liver function in post-menopausal climacteric. The purpose of the current study was to investigate the effects of nonlinear resistance training on levels of alanine aminotransfrase, aspartate aminotransfrase, alkaline phosphatase, Gamma-glutamyl transferase, total bilirubin, and platelet count in post-menopausal women with obesity and nonalcoholic fatty liver disease.
A total of 23 post-menopausal women with non-alcoholic fatty liver disease, between 60 to 71 years old, were randomly assigned to resistance training (n=12) and control (n=11) groups. The experimental group received 12-weeks of the resistance training with different intensities and the participants in control group continued their normal sedentary life. Blood samples were obtained before and after the protocol. Data was analyzed running one-way ANCOVA and paired t test using SPSS (version 22) (p Alanine aminotransfrase (p=0.013) and aspartate aminotransferase (p=0.000) levels significantly decreased in resistance training group but not in control group (p>0.05). Alkaline phosphatase, Gamma-glutamyl transferase, total bilirubin, and platelet counts did not significantly change in the two groups (p>0.05), while muscle strength was improved in resistance training group (p=0.000).
The results showed that with aging, menopausal transition, inactivity, weight gaining, and prevalence of non-alcoholic fatty liver disease were evident. These factors would endanger the health of post-menopausal women. But nonlinear resistance training is helpful to improve liver function and muscle strength. These findings can be helpful for physicians, coaches, and designers of training plans to reduce the side effects of drug therapy.