The vast expanse of the oceans and high biodiversity of such ecosystem, especially in microorganismchr('39')s community has been known as a huge source of marine natural products. Marine natural products are natural compounds derived from the marine organisms which are used in diverse fields of industries, food industries, pharmaceuticals, beauty products, health products and etc. Due to natural source of such compounds, they are environmental friendly and have fewer side effects compare to synthetic compounds. Today, there is an especial look for these great sources in many countries and also several researches have been conducted to study the extraction of these compounds and their diverse effects. Marine microorganisms are a huge part of marine bio-richness, and for this reason they make a suitable source for extraction of marine natural products. In present study, there is a brief introduction to marine natural products whit emphasis on the compounds extracted from marine microorganisms.

Radiodermatitis (RD) is experienced by many cancer patients ‎receiving radiotherapy. An increasing number of these patients demand alternative natural therapies. This study aimed to review the natural products application in cancer patients who experience RD.‎ A search of studies published from 1990 to ‎‎2020 in the ‎databases including PubMed, Scopus, and Google Scholar was performed with the keywords relevant to “Radiotherapy” “Dermatitis” and “Natural Products”. Out of 73 papers obtained, 40 papers were excluded which described only protocols or were non-clinical, non-English language, or without full text. The obtained studies were ‎discussed in detail according to the outcomes and potential mechanisms of action for each natural ‎product.‎ Clinically studied natural products were found to show several outcomes from non-effective to effective in diminishing various items of RD. Outcomes on the effectiveness of Aloe vera were diverse. Some trials suggest that Silybum marianum, Boswellia, Nigella sativa, olive oil, Lianbai, and Hypericum perforatum as well as some multi-ingredient products might be effective prophylactic treatments for RD. Potential mechanisms of these natural products included topical hydrating, anti-inflammatory, antioxidant, and wound ‎healing activities. Results from this review shows that there are some promising natural product options for the prevention and treatment of RD via their multifactorial bioactivities. However, additional research is needed before any definitive conclusions. A larger sample size, optimum doses and duration of intervention as well as investigation of treatment effects in diverse populations and comorbid complications would also be essential in future studies.

Natural products have been always using for several types of applications by humankind for so many years. Food and medical applications have been seen very much important for such products in their original forms or reproduction in new forms. As a main resource for generating so many other compounds, synthetic derivatives have been evaluated for the essential extractions of natural products for more specified applications especially for medical core with controlled dosage medication and compounds. Therefore, recognition of potency of natural products for such specified application have been always seen as a dominant factor for undergoing further improvements in this case. Besides the original extracted essentials, modifying chemical structures could help for lead optimization of such important compounds for possible efficient cares. Indeed, lead optimization could be provided very well by employing in silico approach for potent chemical compounds up to reaching them to specified medication.

Monosodium glutamate is a sodium salt of a nonessential amino acid, L-glutamic acid, which is widely used in food industry. Glutamate plays an important role in principal brain functions including formation and stabilization of synapses, memory, cognition, learning, as well as cellular metabolism. However, ingestion of foodstuffs rich in monosodium glutamate can result in the outbreak of several health disorders such as neurotoxicity, hepatotoxicity, obesity and diabetes. The usage of medicinal plants and their natural products as a therapy against MSG used in food industry has been suggested to be protective. Calendula officinalis, Curcuma longa, Green Tea, Ginkgo biloba and vitamins are some of the main natural products with protective effect against mentioned monosodium glutamate toxicity through different mechanisms. This review provides a summary on the toxicity of monosodium glutamate and the protective effects of natural products against monosodium glutamate -induced toxicity.

The scope of the present review article is associated with diverse synthetic protocols and significance of N,N′-linked bisindole core. The chemistry involved in making of this type of extremely rare heterocycle always of high significance for the chemists in the field of synthetic chemistry as well as in natural products. The interest becomes need when the motif exists in some bioactive natural products. A detailed discussion has been confined to the literature published till September 2022. To our knowledge, this is the first review article on N,N′-bisindole motif.

Cardiovascular disease (CVD) and diabetes mellitus (DM) are the pressing global health issue, with advanced glycation end products (AGEs) playing a crucial role in its development. AGEs are harmful compounds formed through chronic exposure to elevated blood glucose levels and oxidative stress, both of which are prevalent in diabetes mellitus. These molecules have detrimental effects on vascular function, inflammation, and oxidative stress, exacerbating CVD progression. Conventional strategies for managing AGEs are often limited by side effects and insufficient efficacy, driving the need for alternative approaches. This review investigates the intricate relationship between AGEs, diabetes mellitus, and CVD, with a focus on the therapeutic potential of natural products-particularly phenolic compounds. The review explores how AGEs contribute to the pathogenesis of diabetes-related complications and their impact on cardiovascular health. It examines the molecular mechanisms underlying AGE formation and the inhibitory effects of various natural compounds on this process. Additionally, the review assesses preclinical and clinical evidence supporting the efficacy of these natural agents in mitigating AGE-induced damage. By highlighting the significant role of AGEs in diabetes and CVD, the study underscores the potential of natural products to counteract AGE accumulation. It provides an in-depth analysis of AGE biochemistry, their sources, and the effects of different natural products on AGE formation. The review concludes by emphasizing the promise of natural compounds in reducing oxidative stress and inflammation, and thereby lowering the risk of cardiovascular complications associated with diabetes. This comprehensive overview advocates for the integration of natural products into therapeutic strategies for managing AGE-mediated cardiovascular and diabetic conditions.