Human papillomavirus (HPV) is the most important initiator of cervical cancer and its mortality. Despite the significant effectiveness of the HPV vaccine in preventing this cancer, vaccination rates remain low in many communities. The present study was conducted with aim to review the challenges and barriers to vaccination based on the health belief model (HBM) in women of childbearing age.

In this review study, the reliable databases were searched by two independent researchers following PICO guidelines and using MESH keywords including: Papillomavirus Infections, Human papillomavirus, Papillomavirus Vaccines, Health Belief Model, Self-Care, Patient Participation, Health Education, needs assessment and women. The process of selecting articles was based on the PRISMA flowchart and quality assessment of articles was done using the NOS and CASP checklists.

After reviewing and evaluating the quality of 2258 articles, 13 articles with 6030 women entered the review. According to the results, challenges and barriers were in three major categories: individual, psychosocial, and organizational. The most significant individual barriers included inadequate or incorrect information about the virus and perceived invulnerability against its pathogenicity. The most significant psychosocial barriers included fear and shame among women and the taboo of Sexually transmitted diseases. Unavailability of HPV vaccine, ineffective communication with clients, and communication and care gaps were also the major organizational barriers.

According to the results of this study, strategic approaches including enhancing women's knowledge of HPV, providing sexual counseling services, and implementing routine and free HPV vaccination should prioritize in national sexual health policies and programs. Furthermore, health care providers should be trained to establish effective and continuous communication with clients.

The most important factor initiating cervical cancer is human papilloma virus (HPV) infection; although the HPV vaccine can significantly prevent the infection in women, there is contradictory findings about its side effects such as premature ovarian failure (POF). The present systematic review was conducted with aim to determine the association between this vaccine and POF.

This study was conducted by search in the reliable databases of PubMed, Web of Science, Google Scholar, Embase, and Scopus by two researchers independently based on the PICO guidelines and the use of Mesh terms including Papillomavirus vaccine, Human Papillomavirus Recombinant Vaccine Quadrivalent, Primary Ovarian Insufficiency and Premature Ovarian Failure. Newcastle - Ottawa checklist was used to evaluate the quality of articles.

After review and evaluation of the quality of 128 primary articles, finally 7 articles were included in the systematic review. According to the results of population-based studies, there was no significant relationship between the HPV vaccine and POF; but there are case series which support the association between the HPV vaccine and POF. They declared that the cause of this complication was the induction of autoimmune response by the vaccine and the side-effects of the adjuvant used in it.

Considering that the HPV vaccine is currently the most effective approach in preventing cervical cancer, it seems more reasonable to use preventive benefits of this vaccine. Further studies emphasizing the possible side effects of the vaccine can minimize the challenges associated with this vaccine in the future.

The prevalence of human papilloma virus (HPV) is growing in the world. According to the precancerous role and the importance of prevention, human papilloma virus vaccination is considered in all countries. The knowledge and attitude of patients have a considerable effect on HPV injection. It seems that higher knowledge level of physicians can have significant effect on justification and informing target group for vaccination.
The aim of this study was to determine the level of knowledge and attitude of medical students regarding human papilloma virus vaccination and associated factors in Guilan University of Medical Sciences.
This analytic cross-sectional study was carried out on 90 medical students who entered in 2005 and 2006 by census method. Inclusion criteria were studying in final year and would like to participate in the study. In 2012 Data were gathered by a questionnaire including three sections: demographic characteristics (6 questions), knowledge (20 questions) and attitude (26 questions). In scoring knowledge questionnaire, correct, don’t know and incorrect answers received 1, 0 and -1 respectively. 1-3 likert scale was used to score the attitude questions. Agree, don’t know and disagree received 3, 2 and 1 respectively. The level of knowledge score was -20 to 20 points and the attitude included 26-78 points. For data analysis, descriptive statistics including mean, standard deviation, frequency and analytic statistics including T-test and Pearson correlation coefficient were used.
Findings indicated that most participants (82.2%) were female and 66.7% aged less than 25 years. The main source of information about HPV was from courses taken during medical school (57%). Mean of knowledge score was 5.17±3.24 (answers ranging 5-13) and mean of attitude score was 52.16±5.04 (answers in ranging 38-63). There was no significant difference between knowledge and attitude about HPV and sex, age groups, marital status and medical student’s source of information. Also, no correlation was noted between knowledge and attitude about HPV (P=0.28, r=0.11).
Based on study results, the level of Knowledge and attitude of medical students about HPV vaccination was low. Also in attention to the source of student's information, special attention to educational contents for knowledge and attitude promotion is important for future physicians. Therefore educational programs are needed to increase student's knowledge during study especially during clinical education on HPV and vaccination. On the other hand with attention to the role of physicians in giving information to society, better knowledge and understanding of students regarding role of vaccination and decreasing mortality of cervical cancer can take a step to promote the condition of societal health.

A development in the prevention of cervical cancer in women in Australia was the introduction of the human papillomavirus (HPV) vaccine, which was made available to young women as part of a national school-based vaccination program in 2007. Despite this advancement, Pap screening is still required to provide optimal protection from cervical cancer. The current study aimed to explore what young women know about HPV, HPV vaccination, and Pap screening guidelines. It further aimed to identify barriers and facilitators young women perceive to participating in screening, as well as factors influencing these perceptions.
Semi-structured interviews were conducted with 12 women who had been in school during the Australian HPV vaccination program and offered HPV vaccine, aged 18-25, until saturation around key themes was reached. Transcripts were analysed, letting themes emerge from the data.
Key barriers and facilitators to pap screening were identified, as well as factors affecting the salience of these barriers and facilitators.
Findings have implications for the development of interventions to increase screening adherence and reduce the incidence of cervical cancer in this population.

Human papillomavirus (HPV) is the most common sexually transmitted infection worldwide, especially in people with age of under 25 years. It is often caused due to lack of awareness and misconception. Given the precancerous role of this virus and the importance of its prevention, HPV vaccination has been considered in all countries; so it is necessary to improve the knowledge and attitude of adolescents. Therefore, awareness and attitudes among high-risk groups need to be improved, especially among the vulnerable teens. This systematic review was conducted to evaluate the effect of educational interventions on knowledge and attitude of adolescent girls about HPV vaccine.

All quantitative studies, which were published without time limit, were entered in this systematic review article. The investigation was performed in the English and national databases such. Keywords were as Knowledge, Attitudes, Papillomavirus Vaccines, Gardasil, and Intervention study combined with the Boolean OR and AND operators. Finally, two researchers independently reviewed the articles for the quality appraisal and extracted their main findings.

Finally, 21 articles with a total sample size of 10086 were entered the study. Articles were interventional types and were published from 2008 to 2019. Educational interventions were based on Health Belief Model, Peer Education Model, School-Based Interventions, and other Educational Interventions. The Health Belief Model and School-Based Interventions were the most common frameworks for designing educational interventions for the HPV vaccine among adolescents. In all studies, educational interventions had a positive effect on increasing adolescents' knowledge and attitude toward the HPV vaccine.

Educational interventions can lead to increased knowledge and attitudes towards HPV vaccine. Considering the effectiveness of educational interventions based on the Health Belief Model and School-Based Interventions to increase adolescents' knowledge and attitude about this vaccine, designing and implementing such interventions in school are recommended.

The Willingness to pay (WTP) for and acceptance of cervical cancer prevention (CCP) methods have an important role in the control of this type of cancer. Therefore, the aim of this study was to estimate the WTP and acceptance of CCP methods with the contingent valuation method (CVM).

In this systematic review and meta-analysis study, the required information was collected by searching relevant keywords in PubMed, Scopus, Embase, Web of Knowledge, and their Persian equivalent in the Scientific Information Database (SID) and Elmnet databases during  January 1, 2000 to June 30, 2020‎. All studies that reported the WTP and CCP methods with the CVM in English or Persian were included. The reporting quality of studies was assessed by strengthening the Reporting of Observational Studies in Epidemiology (STROBE). Comprehensive meta-analysis (CMA: 2) software was used to conduct the meta-analysis. The content analysis method was used for qualitative data analysis.

Finally, 28 articles (with 49610 people) were included in the study. Most of the participants were women (35.7%). The HPV vaccine was the most common method of prevention (75%). The overall acceptance rate was 64% and the overall positive WTP rate was 66%. The average WTP was US$30.44, which accounts for about 0.84% of GDP per capita. The most significant effective factors included income, age, education, high-risk sexual behaviors, and awareness of cervical cancer, belief in the risk of cervical cancer, and belief about the effectiveness of prevention methods. The cost was the most important reason for the unwillingness to pay and accept.

Results show that the WTP and acceptance rate of CCP methods are relatively high. It is recommended to reduce the cost of prevention methods, especially the HPV vaccine, and to increase awareness and improve the attitude of people. Also, it is recommended to consider other methods of estimation of WTP and other cancers in future studies.

Adolescents are prone to Sexually Transmitted Diseases (STDs) such as Human Papilloma Virus (HPV). Although HPV is a preventable disease, the vaccination rate is low. As parents should vaccinate their children to prevent HPV, the goal of this study was to identify the factors related to mother’s intention to vaccinate adolescents against HPV.

This cross‑sectional study was performed in Qazvin from 2019 to 2020. The participants included 126 literate mothers who had a daughter between 12 and 14 years and health system information registry. To collect the data, a questionnaire was made based on the educational model of behavioral intent. Parents were interviewed in person in health centers or via phone at home. Data were analyzed using Spearman’s correlation.

The mean (SD) age of the mothers, fathers, and girls were 39.60 (6.18), 43.51 (7.58), 13 (0.82) years, respectively. They hadn’t received education regarding HPV. The mean (SD) of the knowledge, attitude, and HPV vaccination intention scores were 27.77 (18.08), 67.38 (10.25), and 15.44 (18.44), respectively. The factors related to HPV vaccination intention were parents’ knowledge (r = 0.29, p = 0.001), positive attitude (r = 0.22, p = 0.010), parents’ education (r = 0.22, p = 0.050) and family income (r = 0.21, p = 0.010).

The high cost of vaccines, economic problems, and lack of knowledge were strong limitations for HPV vaccination. Thus, health workers should have informed parents and teens of the benefits of HPV vaccination. This process should be supported by policy makers.

Different strategies can promote healthy behaviors. Although the human papillomavirus (HPV) vaccine is very important due to its effect in reducing cervical cancer, the behavior of HPV vaccination is low among young adults in Iran. Therefore, this study aimed to determine strategies for improving HPV vaccination among young adults.

The present study was conducted with a qualitative content analysis method. The participants were 30 health professionals and young adults in Tehran city who were selected using purposive and snowball sampling. The data were collected through semistructured interviews and analyzed by Graneheim and Lundman’s approach.

In total, two categories were identified: (1) access to services: access to the vaccine, vaccine insurance coverage; (2) educational coverage: subgroup training, educational content, time for training, educational channels, education strategies, and educational conditions.

This is the first study conducted to determine strategies for improving HPV vaccination in Iran. The policymakers and planners, schools, and health centers are recommended to use the strategies obtained from this study to increase HPV vaccine imports, as well as increase the community members’ knowledge and acceptance of the HPV vaccine.

Human papillomavirus (HPV) is the most common sexually transmitted infection and causes more than 90% of cervical cancers. The highest rate of infection occurs between the ages of 18 and 28. This study aimed to determine the effect of education based on the theory of planned behavior (TPB) on the intention of vaccination against HPV in female students.

This controlled educational trial study was performed on 72 female students aged 18–26 years of Mashhad University of Medical Sciences by random assignment to intervention and control groups. For random assignment in the intervention and control groups, random blocking with four blocks was performed using a random number table with a ratio of 1:1. Data collection tools included demographic questionnaire, awareness about HPV vaccination, and TPB theory constructs. The control group was received the university routine training. The intervention group was received the virtual group training in four sessions, 60–90 min at weekly intervals and with educational content including TPB constructs on HPV vaccination with the method of lecture training, group discussion, questions and answers, and presentation of training package. Questionnaires were completed before, instantly, and 1 month after the educational intervention. Data were analyzed using the Chi‑square test, Fisher’s exact, t‑test, Mann–Whitney test, and Friedman test.

The mean age of students was 18.9 ± 1.1 years. The intervention and control groups were homogeneous in terms of demographic characteristics (P > 0.05). Before the intervention, the mean score of model constructs did not show a statistically significant difference between the two groups (P > 0.05), but after the intervention, in the intervention group, mean scores of attitude, subjective norms, perceived behavioral control, and behavioral intention in the intervention group was significantly higher than the control group (P < 0.001). In the intervention group, the difference in the mean score of HPV vaccination intention instantly (P < 0.001) and 1 month (P < 0.001) after the intervention significantly increased.

TPB‑based education was effective in increasing attitudes, subjective norms, and perceived behavioral control and the intention to vaccinate against HPV in the female students of Mashhad University of Medical Sciences. Therefore, it is suggested that the present educational intervention be widely used to educate female students.