International journal of basic science in medicine
Volume:1 Issue: 1, Jun 2016

It is suggested that constipation could be due to celiac disease (CD); therefore, this study aimed to determine the prevalence of positive tissue transglutaminase (tTG) IgA test among children with functional constipation (FC).
In this case-control study, 182 consecutive patients with FC who fulfilled the Rome III criteria as cases were compared with 240 healthy children as the control group in terms of suspicious CD by measuring the serum tTG IgA level.
There was a significant difference in favor of the case group in terms of serum tTG IgA levels (P = 0.000). The probability of having CD would change based on belonging to each group (case/control odds ratio [OR] = 0.222).
With respect to these data, tTG IgA level was observed to be significantly higher in patients relative to healthy children; therefore, it is recommended that patients be screened for CD through the tTG IgA.

Circadian rhythm and physical activity are factors that influence the homeostasis of blood. This study aimed to investigate the effect of exhaustive exercise in the morning and evening on the blood hemostasis in female athletes.
In the present quasi-experimental study, 30 female athletes aged 18-25 were selected by convenience sampling method and randomly divided into two groups (morning and afternoon exercises). The standard Bruce protocol test was used. In the present study, platelets, fibrinogen, and thromboplastin time were measured as indicators of blood coagulation before and after testing. Paired t-test and covariance analysis were used to analyze the measured indices and P ≤ 0.05 was considered significant.
An acute exhausting aerobic training session in both groups significantly increased platelet and fibrinogen levels, but a significant decrease was observed in thromboplastin time. Considering the training time, significant difference was observed in the blood thromboplastin time in the morning in comparison with the afternoon.
According to the results of this study, the circadian rhythm and acute exhausting aerobic training are effective factors on the blood coagulation and a training session in the morning compared with the evening training has a greater effect on the blood coagulation.

In today’s world, chronic diseases are predominant health problems and cause heavy burden on society; therefore early diagnosis and even prediction of the disease is a way to reduce this burden. In this project, we tried to use recommender system to predict which other diseases a chronic patient is susceptible for.
In this study, through a dynamic recommender system, we evaluated patients’ treatment destiny during the time.
It was shown that our method increased accuracy and reduced error compared with other recommendation methods in disease prediction.
Compared to current usual methods, in our method we used previous patients’ characteristics as one of the factorization variables to predict destiny of future patients. Furthermore, using this method, we can predict which complication or disease the patient would suffer from first in future. Therefore, we can manage policies toward disease burden reduction by implementing prevention programs.

Changes in hormone levels especially testosterone and cortisol occur as a result of exercise intensity. In other words, the exercise intensity significantly influences these changes. The aim of this study was to investigate the effects of aerobics-resistance (concurrent) exercise intensities on the serum testosterone and cortisol levels in the active men.
In this clinical trial, 10 healthy men were included in their combined activities in low, medium, and high levels. Different intensities (aerobic activity such as running on a treadmill at a speed of 8, 6.9, and 11.2 mph and resistance exercise on 45%, 65%, and 85% of maximum strange, maximum of six moves) were considered for all participants for unity. Blood samples were measured in three phases (baseline, immediately after exercise, and 24 hours after training contracts) at three levels. Two-way analysis of variance (ANOVA) with repeated normal data and Bonferroni post hoc test were conducted.
The results showed that cortisol and plasma lactate concentration was declined immediately before and 24 hours after the combined exercise with the significant level of activity (P In this study, the intensity of training as an independent variable influencing the changes in the levels of testosterone and cortisol has been recommended; so highly sportaffected hormonal changes during the combined exercise should be considered more than that in one exercise.

Antimicrobial resistance is one of the major characteristics of infectious agents. Silver nanoparticles (AgNPs) have been introduced as novel antibacterial agents in accordance with the traditional treatments. Our purpose of this study was to evaluate the antimicrobial activity of AgNPs on the Pseudomonas aeruginosa (P. aeruginosa) that are resistant to antibiotics.
During a cross-sectional study, we tried to evaluate 20 strains of P. aeruginosa isolated from the urine cultures of patients admitted to the hospital due to urinary tract infections. The AgNPs were commercially purchased. The minimum inhibitory concentration (MIC) of AgNPs in different concentrations was determined by the dilution in wells on bacteria. The antibiotic susceptibility pattern of P. aeruginosa was evaluated by the Kirby-Bauer disk diffusion standard.
Current study indicated that P. aeruginosa were resistant to four types of agents including ampicillin (85%), nitrofurantoin (65%), nalidixic acid (65%), and ciprofloxacin (15%) and result of nanosilver indicated that the most MIC was 100 ppm concentration, and six strains of P. aeruginosa were inhibited by it.
Our study presented a new type of silver nanoparticle and indicated that they can be embedded in bone cement to prevent infections once synthetic conditions are tailored for such applications.

The role of chemokines and their receptors have been identified in many biological activities such as immune response and angiogenesis; however, their regulatory ways are under investigation. In recent years, homologous proteins’ typical chemokine receptors have been identified. Despite the structural similarity due to changes in a particular motif, they are not able to create signals through G proteins within the cell; therefore, these chemokine receptors are called silent or unusual. Through binding and internalization and degradation of the chemokines, these receptors regulate the level of ligand in the environment. In this paper, about fifty articles published in the field of the regulatory role of CCX-CKR receptor in some human diseases such as cancer and inflammatory diseases were reviewed. CCX-CKR is one of the chemokine binding proteins that like other silent chemokine receptors, is not able to induce intracellular signaling pathways. Since chemokine network plays a major role in many diseases such as cancer and autoimmune diseases through the impact of CCX-CKR on the level of chemokine environment, preventing intracellular signal creation by these proteins can be considered as a therapeutic target.