مجله غدد درون ریز و متابولیسم ایران
سال بیست و یکم شماره 2 (پیاپی 104، خرداد و تیر 1398)

Hypothyroidism is one of the most common endocrine diseases, with an incidence of 2-10% in different populations. The purpose of this study was to investigate the effectiveness of acceptance and commitment therapy on the anxiety, depression psychological well-being of patients with hypothyroidism.

This quasi-experimental clinical trial study was performed on thirty women with hypothyroidism, who were selected using the purposive sampling method and randomly assigned in two groups, the intervention and controls (n=15 each). Data were collected using the Beck Anxiety inventory (BAI) Beck depression inventory (BDI) and psychological well-being Reef. Data analysis was done by SPSS-21 software and using the repeated measures ANOVA and Benferroni post hoc test.

Results of the repeated measure of variance analysis showed a significant difference between the performance of the experimental and control groups in anxiety (P=0.001, F=14.16) depression (P=0.001, F=13.12) and psychological well-being (P=0.001, F=26.60) in the post-test stage and after three months of follow-up.

Findings indicate the effectiveness of ACT therapy on the anxiety, depression and psycholgical well-being of patients with hypothyroidism; confirming that this intervention can be used as a complementary treatment, along with medication, to improve the quality of life of these individuals.

Over weight is one of the most important public health concerns and the most common fat metabolism disorder in humans the purpose of this study was to compare the effect of eight weeks of interval training and vitamin D intake on DPP4 and RBP4 plasma levels of overweight with mean age of 39.92±4.15 , height 159.25±3.8 cm weight 72.73 kg /m2 in this study , 40 subjects were selected purposely and randomly assigned to four groups of exercise , vitamin D training and consumption complement and control . At first , the height , weight , BMI was measured in the subjects the next day , after 14 hours of fasting The initial blood sample was taken at 5 mm from the subject and the levels of RBP4, DPP4 glucose were measured insulin , resistance was measured and then the interval training program included the neighborhood 30 runs were at maximum speed with one and half minutes of active rest between each time for 8 weeks and three sessions per week the subjects were in vitamin D and interval training with vitamin D intake per week A vitamin D capsule with a dose of 50/000 unite taken with lunch for eight weeks in order to compare the pre-test and post test data in each group , t-test was used and for comparison between groups. AVOVA was used. All true calculations , which were considered less than 5% showed that the eight-week training period of vitamin intake Diet and exercise with vitamin D supplementation on biochemical indices including DPP4 , RBP4 fasting insulin glucose insulin resistance and body composition including weight and BMI of overweight women had a significant effect. Our findings indicated that exercise vitamin D and interval training with vitamin D supplementation reducing the risk factors for overweight diseases such as diabetes such as diabetes and cardiovascular disease is possible by reducing DPP4, and RBP4, fasting glucose and insulin resistance.

Obesity is a very important cause of many chronic diseases. One of the ways to control weight and obesity is to have regular physical activity and the use some medicinal herbs. The purpose of this study was to investigate the effects of ginger supplementation per se and in combination with high intensity interval training (HIIT) on the anthropometric indices and serum levels of irisin in obese men.

Sixty-four obese men, aged 20 to 35 years were randomly assigned into 4 groups for 10 weeks: Group 1) ginger supplement, Group 2) ginger supplement+training, Group 3) training+placebo, and Group 4) placebo. Individuals in groups 1 and 2 (ginger and ginger+training), received three ginger capsules (1 g daily) and subjects in groups 3 and 4 (training group+placebo) and placebo groups received the same amount of placebo capsules with each meal. Participants in the ginger+training and training+placebo groups participated in a HIIT protocol for 10 weeks.  Data on anthropometric measurements, serum irisin levels and dietary intakes were collected at the beginning and at the end of the study.

The ginger intervention per se, reduced body fat percentage within groups (P=0.001). In ginger+training and training+placebo groups significant decreases were observed in anthropometric indices including weight, body fat percentage, waist circumference, waist-to-height ratio, compared to the placebo group (P<0.05). No significant difference was observed in serum levels of irisin in any of the studied groups at the end of interventions (P>0.05).

HIIT exercises alone and in combination with ginger were effective in improving anthropometric indices.

Thyroid hormones are involved in the regulation of hydrogen sulfide (H2S) biosynthesis. The aim of this study is to determine effects of thyrotoxicosis on H2S levels and mRNA expression of cystathionine-β-synthase (CBS), cystathionine-γ-lyase (CSE) and 3-mercaptopyruvate sulfurtransferase (3-MST) in the adipose tissue of rat.

Male rats were divided into the control (n=8) and thyrotoxicosis groups (n=8). Thyrotoxicosis was induced by adding L-thyroxine (12 mg/L) in drinking water for 21 days. Serum levels of free triiodothyronine (FT3), free thyroxine (FT4), total T3 (TT3), and total thyroxine (TT4) as well as thyroid stimulating hormone (TSH) were measured on day 21. H2S concentrations in serum and epididymal adipose tissue, as well as mRNA expressions of CBS, CSE, and 3-MST in epididymal adipose tissue were measured on day 21.

Serum levels of FT3, FT4, TT3 and TT4 were significantly higher, whereas TSH level was significantly lower in rats with thyrotoxicosis. Compared to controls, H2S levels (µmol/L) were lower in serum (43%, P<0.001) and epididymal adipose tissue (30% P=0.044) of rats with thyrotoxicosis. Thyrotoxicosis decreased mRNA expression of CSE (62%, P<0.001) and increased mRNA expression of CBS (116%, P=0.013) but not 3-MST in the epididymal adipose tissue.

Thyrotoxicosis decreased H2S levels in the serum and epididymal adipose tissue, an effect which can be due to decreased mRNA expression of CSE. Decreased serum and adipose tissue levels of H2S may contribute to the pathophysiology of thyrotoxicosis.

Metabolomics, is a comprehensive measure of small metabolites (<1500 Da), which has attracted enormous attention in the last two decades. Metabolomics, in particular investigates unique biochemical fingerprints left behind by specific cellular processes, which represent the metabolic status. Exercise metabolism researchers have started to use this method since 2007. Metabolomics has been used to study the metabolic response to exercise, supplementation and exercise, sport performance and exercise effects in clinical situation. The purpose of this study was to describe metabolomics and its application in exercise metabolism research and to review research literature (from 2007 to the end of 2018). To this end, to facilitate the analysis, Google Scholar and PubMed databases were searched without date restriction. 58 valid studies were identified and divided into 5 groups, as follows: Metabolic response to exercise (27 studies), exercise nutrition (15 studies), sport performance (7 studies), clinical exercise studies (7 studies) and compare athletes metabolome (2 studies). Due to its high capacity, metabolomics can provide a suitable approach for exercise metabolism studies. On the other hand, because metabolites are the end point of physiological pathways, they can provide more reliable and useful information.