Archives of Iranian Medicine
Volume:23 Issue: 2, Feb 2020

In this study, we seek to evaluate the population health improvements during the previous four decades in Iran. We have estimated the levels and trends of child and adult mortality in addition to life expectancy from 1979 to 2019 at national and sub-national levels using all the available data.

In this study, we used data from National and Sub-National Burden of Diseases study and employed Bayesian Averaging Model (BAM) to predict mortality rates and life expectancy from 1979 to 2019. By including all available data sources of death information of Iran, including national level data from the Institute for Health Metrics and Evaluation (IHME), national censuses, Demographic and Health Survey (DHS), and Death Registration System (DRS) and using Spatio-Temporal and Gaussian Process Regression (ST-GPR) models, we estimated mortality rates and life expectancy from 1990 to 2015. We also used a BAM to project our desired indices until 2019.

Both child and adult mortality rates decreased dramatically over the period. At the national level in Iran, in 2019, child mortality rate (deaths per 1000 livebirths), was 16.0 (95%UI: 13.0–19.6), adult mortality rates [probability of death (%)] for females and males were 6.1 (5.4–6.8) and 11.5 (10.3–12.8), respectively. Also, life expectancy values for females and males were 81.6 (80.7–82.2) and 76.1 (75.3–76.6), respectively. The results were consistent for both sexes. Despite the total narrowing gaps among provinces, a difference can still be observed particularly for the border provinces regarding child mortality rates. However, the difference in the other measures are inconsiderable. From 1979 to 2019, the overall change percent in child mortality rate, adult mortality rate for females and males and life expectancy for females and males were -86.3% (-89.0% – -83.1%), -52.5% (-60.9% – -42.9%), -48.7% (-56.9% – -39.6%), 25.3% (20.8%–31.5%), and 31.3% (25.5%–41.3%), respectively.

This study provides an overview of the previous 40 years of mortality rates (child and adult) and life expectancy. The provided framework of national and sub-national evaluation can be used by researchers to continue the path of providing information for prioritization and evaluation of programs and also performing cost-effectiveness analysis for proposing efficient strategies to policy makers.

Projection of mortality rates is essential for policy making and planning of health services. Premature mortality, as an important index, commonly refers to deaths occurring before 70 years of age. This study was conducted to estimate the trend of premature deaths from 2006-2015 and to project premature deaths for the 2016-2030 period.

We used national mortality data collected by the Ministry of Health and Medical Education’s Deputy of Health, and population data from the Statistical Center of Iran. Mortality and population data were categorized based on sex and 5-year age groups. The Bayesian hierarchical model was used to project future premature mortality rates through 2030.

Age-standardized all-cause premature mortality declines from 414.3 per 100 000 persons in 2010 to 300.3 per 100 000 persons in 2030 (27.5%) for men, and from 230.6 per 100 000 persons in 2010 to 197.2 per 100 000 persons in 2030 (14.5%) for women. In all age groups, the percent reduction of premature mortality was greater for men than women.

Overall, it is projected that premature mortality will witness a declining trend in both sexes in Iran. Accordingly, we would expect to achieve less than a third reduction in premature mortality by 2030, which is one of the Sustainable Development Goals.

Under-five mortality is considered an indicator of population well-being and health equality in societies. Under-five mortality caused by nutritional deficiencies is a public health concern in developing countries. In this study, we aimed to report the trend and mortality rate of nutritional deficiencies from 1995 to 2015 in children aged under five years.

In this study, we used the death registration system (DRS) data to estimate age- and sex-specific nutritional deficiency mortality rates at national and sub-national levels in Iran from 1995 to 2015. The Iranian DRS used the 10th revision of International Classification of Diseases (ICD-10) but we report our results based on Global Burden of Diseases (GBD) study codes. We used the average annual percent change (AAPC) to quantify trend in under-five mortality rate attributable to nutritional deficiencies from 1995 to 2015.

At national level, mortality rates in both sexes were 8.53 (95% uncertainty interval [UI]: 7.69–9.47), 1.04 (0.86–1.36), and 0.37 (95% UI: 0.28–0.57) per 100,000 in 1995, 2005, and 2015, respectively. AAPC was estimated between 1995 and 2015. At sub-national level, the highest and lowest mortality rates across provinces ranged from 17.7 per 100 000 in 1995 to 1.1 per 100 000 in 2015. In the latest years, protein-energy malnutrition (PEM) was the most frequent cause of mortality among other nutritional deficiencies.

The results show a substantial reduction in terms of mortality caused by nutritional deficiencies at national, as well as provincial, level among children under-five years of age.

Preventing violence is important especially in the Middle East, where many countries are struggling with violence. Knowing the affecting factors could help public policy makers to decrease violence level. Thus, this study is aimed to analyze health and other socio-economic factors that could affect interpersonal violence in middle eastern countries.

From international organization databases, we collected the panel data of Middle Eastern countries from 1990 to 2016 on prevalence of interpersonal violence as dependent variable and per capita income, life expectancy, democracy index (DI), urbanization and unemployment as explanatory factors. Several panel data diagnostic tests were performed for selecting a suitable model of estimation. The variables were entered in the model in logarithmic form. Because of heteroscedasticity, cross-sectional dependence and serial correlation of residuals, feasible generalized least squares (FGLS) was used for estimation of mentioned model using Stata 14.2.

The means of interpersonal violence prevalence and life expectancy were 2462.2 (SD = 232.4) per 100 000 population and 73.5 (SD = 4.5) in the Middle East, respectively. Urbanization (β = -0.0925, P < 0.01), life expectancy (β = -0.0362, P < 0.01), per capita income (β = -0.0046, P < 0.01), unemployment (β = 0.0007, P < 0.01) and democracy (β = -5.83e-06, P < 0.01) had significant relation with interpersonal violence.

Life expectancy as a proxy for health is one of the main predictors of interpersonal violence, as literature supports. That is, if a society is healthier, the burden of interpersonal violence will be lower. Thus, health policy makers should consider health status as a preventive factor of violence, which is stated in health as a bridge for peace by the world health organization.

Negative life events (NLEs) and early marriage (EM), a worldwide social silent problem, are increasing in prevalence globally. Evidence is lacking regarding their impact on depression. We assessed the impact of EM and NLEs on depression among adolescents, young adults and adults in Iran.

A population-based descriptive study was performed among urban and rural population aged 13-40 years. Beck depression inventory scale II and life event questionnaire were used to assess the severity of depression and NLEs, respectively. EM was defined as a marriage or union between two persons in which one or both parties are younger than 18.

In a total of 530 participants (300 female and 230 male) with a mean age of 26.78 ± 5.06, almost 46% had depressive symptoms. A trend was found between rising age and depression so that among the three groups of study subjects, adults had the highest prevalence rate (49.34%). After adjusting for age, residence, substance abuse, alcohol abuse, unemployment and other NLEs by multiple regression, we found statistically significant relationships between depression and EM (2.77; CI: 1.75–4.57), and NLEs (2.78; CI: 1.85–4.19). Among types of NLEs, marital conflicts (5.8; CI: 1.60–20.81), loss of loved ones (6.12; CI: 1.28–28.26) and financial problems (13.79; CI: 1.72–108.17) were associated with depression risk.

Life skills improving program with intersectoral collaborative care to reduce determinants of EM and NLEs in the community, as well as training and screening for depression among adolescents and adulthood are necessary.

Clostridium tetani is an anaerobic, gram-positive bacillus that causes tetanus infection. It usually enters the body through injury with contaminated objects. Tetanus differs from other diseases that can be prevented by vaccination in that it is not contagious and does not spread from person to person. The aim of this study is to evaluate the levels of Tetanus IgG in trauma patients admitted to the emergency department (ED).

The study was planned as cross-sectional, prospective, and single-center. The study was conducted from January to July 2018 in the Kahramanmaraş Sütçü İmam University Hospital. Totally, 178 patients aged ≥18 years were included. For measurement of the level of Tetanus IgG, Clostridium tetani toxin 5S IgG kit (NovaLisa, NOVATEC) was used to quantitatively detect IgG type antibodies by micro-ELISA method in accordance with the manufacturer’s recommendation.

In total, 143 cases were male and 35 were female. The mean age of the cases was 40 ± 16 years. Tetanus IgG levels were found to be 0.29 ± 0.6 IU/mL in cases from rural areas and 2.14 ± 1.64 IU/mL in cases from urban areas (P < 0.001). There was a negative correlation between age and Tetanus IgG level (r: (-) 0.479; P < 0.001). The protective level of Tetanus IgG was observed to be even lower, especially in patients aged ≥40 years (n = 43, 78.9%).

Measurements of Tetanus IgG levels should be performed as far as possible in the ED. In this way, unnecessary vaccination can be avoided.

Considering the non-invasive nature of magnetic resonance spectroscopy (MRS) and its ability to detect prostate lesions, the present study aimed to investigate the accuracy of MRS techniques in distinguishing between prostate cancer (PCa) and prostatitis.

Thirty-three patients (18 patients with PCa and 15 patients with prostatitis) were recruited for this study. Magnetic resonance imaging (MRI) and MRS were performed using 1.5-T system GE- modle Optima 450 Discovery (GE Medical Systems, US). The (Cho+Cr)/Cit ratio of hypointense T2 areas were calculated. The diagnostic accuracy including sensitivity and specificity indices, with 0.95 confidence interval as well as PPV and NPV were calculated for each variable. The receiver operating characteristic (ROC) area under the curve (AUC) was outlined and investigated. The mean quantitative values between the two groups (PCa and Prostatitis) were compared using independent t test.

The mean ratios of Cho+Cr/Cit in PCa was 1.54 ± 0.63 and 0.83 ± 0.48 for PCa and prostatitis, respectively, indicating a significant statistical difference (P = 0.00). A reduction in citrate was seen in both PCa and prostatitis tissue. Significant elevation in choline peak was shown for PCa. Moreover, creatinine level was low in both normal tissue and PCa without significant difference. Sensitivity, specificity, accuracy, PPV and NPV of MRS were 94.4% (95% CI, 74.2–99), 80% (95% CI, 54.8–93), 96%, 85% and 92.4%, respectively.

The results of this study indicate an acceptable level of sensitivity, specificity and accuracy of MRS in the differential diagnosis of PCa and prostatitis.

The desperation to publish among the scientific and academic community has reached new pinnacles and a new threat to academic integrity has surfaced in the form of predatory journals. These journals try to attract the young researchers with aggressive advertisements promising an early turnaround time for publication which is through absence of peer review and comes at a cost in the form of article processing fees. Predatory journals are an increasing menace affecting research integrity since they assist in author misconduct. They exploit its very foundation which aims at conducting and reporting the research in a truthful way that in turn builds trust and confidence for science in the society. This review gives an overview of predatory journals, their modus operandi, the ethical concerns associated with them and means to curb this menace.

Herbal medications are becoming increasingly popular with the impression that they cause fewer side effects in comparison with synthetic drugs; however, they may considerably contribute to acute or chronic poisoning incidents. Poison centers receive more than 100 000 patients exposed to toxic plants. Most of these cases are inconsiderable toxicities involving pediatric ingestions of medicinal plants in low quantity. In most cases of serious poisonings, patients are adults who have either mistakenly consumed a poisonous plant as edible or ingested the plant regarding to its medicinal properties for therapy or toxic properties for illegal aims.

In this article, we review the main human toxic plants causing mortality or the ones which account for emergency medical visits. Articles addressing “plant poisoning” in online databases were listed in order to establish the already reported human toxic cases.

The current review introduces herbal plants toxicity and herb-drug interactions to warn the health professionals about possible consequences of unconscious uses of medicinal plants. The reported cases extracted from our prepared database were classified on the basis of the main toxic effects of plants, and the most prominent constituents of the plants which are responsible for specific toxic effects.

Considering the long history of consumption of herbal medicines in different societies, people may wrongly think that medicinal plants are fully harmless and nontoxic. Prescription, preparation and consumption regulations of medicinal plants are not clear and strict as well as their marketing regulations that differ from country to country. The extensive and various consumption of medicinal plants without adequate observation is the most important reason for poisoning by medicinal plants.

Diagnosis and timely treatment of neonatal jaundice and prevention of dangerous side effects of pathologic neonatal jaundice remain a serious debate. The first step in prevention of jaundice is the identification of predisposing factors. The present study aims to systematically review the maternal risk factors of neonatal hyperbilirubinemia.

For this study, we searched databases including Science Direct, Cochrane Library, ISI, PubMed and Google Scholar from 1993 to 2017. The keywords searched based on MESH included hyperbilirubinemia, jaundice, infants, mothers and risk factors. The present systematic review was conducted on studies reporting maternal risk factors for neonatal jaundice. The inclusion criteria were: study on neonates; examination of maternal factors or both maternal and neonatal factors. Papers associated with the diagnosis and treatment of neonatal jaundice were excluded from the study, as well as those articles for which only abstracts were available. The limitations of this study include lack of access to all relevant articles, lack of qualified reports in some papers, and the limitation in number of articles related to maternal risk factors, and therefore inability to judge accurately about their effects on neonatal jaundice.

Of 500 searched articles, 17 articles (1 prospective article, 2 retrospective papers, 12 cross-sectional papers and 2 historical cohort articles) were finally investigated. Maternal risk factors included hypertension, diabetes, type of delivery, vaginal bleeding, premature rupture of membranes (PROM), maternal age, lack of initiation of feeding during the first hours of life, inappropriate breastfeeding techniques and presence of maternal breast problems.

The most common maternal risk factors for neonatal jaundice were prematurity, blood type incompatibilities, preeclampsia, hypertension, diabetes mellitus, vaginal bleeding, delivery problems (type of delivery, labor injuries, delivery at home, skin ecchymosis, and cephalohematoma), mothers and community cultural beliefs (use of traditional supplements), breast problems, and decrease in breastfeeding.

Clozapine is known as one of the atypical antipsychotics which is placed in the second line of medical treatment for schizophrenia due to its hematologic complications. It is used in cases of resistance to treatment. Some side effects of clozapine include leukopenia, granulocytopenia, fever, hepatotoxicity, sedation, dizziness, hypotension, weight gain, constipation, and seizure. Neutropenia and hepatotoxicity have been separately reported after taking atypical antipsychotics, including clozapine. However, simultaneous occurrence of these two complications is rare and has not been reported with clozapine use. This study reports a case of concurrent hepatotoxicity and neutropenia induced by clozapine. The patient was a 58-year-old man who started taking clozapine for the first time in March 2017, about seven weeks before his recent admission, because of a history of treatment-resistant schizophrenia. He had been referred to the emergency department of a general hospital with symptoms of weakness, lethargy, fever, and chills. The laboratory results showed neutropenia with a frequency of 352 × 103 (17.5%) and hepatotoxicity with alanine transferase (ALT) = 139 u/L, aspartate transferase (AST) = 214 u/L, total bilirubin = 11.5 mg/dL, and direct bilirubin = 9.3 mg/Dl, caused by taking clozapine. The symptoms were attenuated within eight days after discontinuation of clozapine. Moreover, the patient’s para-clinical complications including neutropenia, and raised transaminases and bilirubin returned to normal. It was concluded that clozapine can simultaneously cause neutropenia and hepatotoxicity; physicians are recommended to be aware of this issue to prevent mortality through appropriate and timely diagnosis.