فهرست مطالب

Journal of Chemical Health Risks
Volume:10 Issue: 1, Winter 2020

  • تاریخ انتشار: 1398/12/14
  • تعداد عناوین: 8
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  • Abba Babandi *, Murtala YaU, Hafeez Muhammad Yakasai, Dayyabu Shehu, Kamalludeen Babagana, Aminu Ibrahim, C.A Anosike, Lawrence Ezeanyika Pages 1-15

    Chemical elements such as heavy metals significantly functions as trace elements but their bio-toxicity to human biochemical process poses a great concern for public health. The human exposure to heavy metals via food chain has been a documented risk factor for cancer development and other health-related implications. The levels of some carcinogenic (Chromium Cr; Cadmium Cd and Lead Pb) and non carcinogenic (Nickel Ni; Cobalt Co; Copper Cu and Zinc Zn) heavy metals in vegetables (Onion, Drumstick, Lettuce, Okra, and Carrot) grown in Sharada industrial area, Kano were evaluated. The human health risk implications were also determined by estimating the daily metal consumption, and calculating non cancer and cancer risks (Incremental Life Cancer Risk, ILCR and Target Hazard Quotients) using US-EPA probabilistic health risk assessment (US-EPA risk predicting model). The mean concentration of lead (Pb) ranged from 11.21±0.55 µg/g in Okra to 16.84±0.86 µg/g in onion. Carrot had the highest concentration of chromium (65.10±3.20 µg/g). The levels of various heavy metals found in the studied vegetables/plants differ generally with plant species. The predictive values of human developing cancer disease from the incessant intake of studied plant/vegetables was found higher than the standard threshold risk boundary set by US-EPA, (>10-4) for Cr, Pb, and Cd. The non cancer health risk values also predicted Pb, Cr and Cd as the dominant metal contaminants of the vegetables with the Health Risk Index greater than one (>1), while Ni, Co, and Zn showed safe quotients. Among the studied vegetables/plants, carrot has predicatively, the highest cancer risk (∑ILCR 1.25 with chromium contributing 92%), followed by lettuce, onion, Moringa oleifera, and okra (Carrot> Lettuce > Onion > Moringa > Okra). It is, therefore, suggests that the industrial area is unsafe for irrigation due to the heavy metals pollutions of the soil and irrigation water and the risk of high consumption of vegetables grown exposes the population to incremental cancer risks potential among others.

    Keywords: Vegetables, Heavy metals, Carcinogenic risk, Health risk, ILCR, HLI, Kano
  • Farzaneh Rezaei Ranjbar, Farhad Khamchin Moghadam * Pages 17-24
    Currently, there is a serious water crisis in the world, which necessitates the purification of polluted water. Nowadays, new methods have been presented for the treatment of contaminated water. In the present study, single- and multi-walled nanotubes were used for adsorption of aspirin and atrazine pharmaceutical pollutions from waste water. In addition, various tests were performed at six levels to evaluate the parameters of effects of the initial concentration of solution, level of nano-absorbent, contact duration, temperature and pH on pharmaceutical pollutions of aspirin and atrazine in two single- and multi-walled carbon nanotubes. Moreover, results of each level of the test were separately shown on diagrams based on the concentration percentage. After the comparison of results, it was demonstrated that in the parameter of effect of the initial concentration of solution, the pharmaceutical pollution of atrazine had the highest adsorption percentage (94.03%) in the presence of multi-walled carbon nanotubes. In terms of the total adsorption percentage of aspirin and atrazine, the highest adsorption percentage was observed in the presence of multi-walled carbon nanotubes.
    Keywords: Initial Concentration, Contact Time, Adsorbent Dosage, Multi-walled carbon nanotubes
  • Iya Eze Bassey, Uwem Okon Akpan *, Ifeyinwa Maryann Okafor, Imeobong Joseph Inyang, Oko Eze Pages 25-34
    Cigarette smoking has been linked to atherosclerosis, coronary artery disease, peripheral vascular disorders and various malignancies. However, the mechanism by which smoking increases the risk of cardiovascular diseases is still controversial. One hundred and forty one apparently healthy male cigarette smokers and sixty apparently healthy non-smokers aged 18 to 65 years were enrolled into the study. The smokers were sub-divided into light (<8 pack years), moderate (8-30 pack years) and heavy (>30 pack years) smokers. Anthropometric indices and blood pressure were measured. Fasting plasma glucose, total cholesterol (TC), triglycerides and High density lipoprotein-cholesterol (HDL-C) were estimated using colorimetric test methods while low density lipoprotein-cholesterol (LDL-C) and very low density lipoprotein were calculated using Friedewald’s equation. Serum insulin was estimated using ELISA. Data was analyzed using SPSS version 20.0; level of significance was set at p<0.05. The smokers had significantly higher diastolic BP (p=0.0001), TC (p= 0.008) and LDL-C (p = 0.0001) and significantly lower HDL-C (p = 0.0001) compared to the non-smokers. There was a significant higher fasting plasma glucose in the light smokers (p=0.001) than in the moderate and heavy smokers whereas, serum TC and LDL-C levels were significantly increased in heavy smokers (p=0.001) than in the light and moderate smokers. There was a negative correlation between BMI and smoking pack years. Dyslipidaemia was observed to be the most prevalent cardiovascular disease risk factor. It is concluded that the alterations in lipid profile and blood pressure observed in this study may contribute to higher risk of cardiovascular disease.
    Keywords: cigarette smoking, Risk Factors, Lipid profile, cardiovascular disease
  • Amir Hossein Baghaie *, Aminollah Aghilizefreei Pages 35-43

    In this study, we investigate the problems and obstacles of implementing the risk-based auditing in Iran. We set four hypotheses and used questionnaire containing 45 questions to collect the required data. The questionnaires were distributed between Iranian certified public accountants who were partners or directors of audit firms and audit organizations member of Iranian certified public accountant institute. To determine the validity of the research questionnaire limited number of questionnaires distributed between small sample of respondents and their views taken into account. The Cronbach’s alpha test is used to measure reliability of the questionnaire. The results of this study indicated that, lack of the theoretical foundations and regulations of risk-based auditing in Iran, structure and function of auditors and audit firms and factors related to the clients are the obstacles and limitations on implementation of risk-based auditing in Iran Then the most important factors prioritized using fuzzy hierarchy analysis. For this reason, a questionnaire was developed with 16 factors from approved hypotheses. Results revealed that related factors with the auditors and unfamiliarity of auditors with IT and lack of educational resources were the most important obstacles and limitations on implementation of the risk-based auditing in Iran.

    Keywords: Salicylic acid, Pseudomonas putida, Phenanthrene, Degradation
  • Ahmed Talaat Abd Elaziz *, Hanaa Mohamed Elzahed, Shar Hassan Hassan, Bahaa Eldin A. Khaled, Eman H. Nadwa Pages 45-56
    Liver diseases are most commonly occurring nowadays, that’s why we are in argent need to develop new strategies in treatment. to evaluate the role of MSCs in regenerating liver cells and to clarify the anti-inflammatory role of HO-1 either alone or as a combined therapy with MSCs. 72 rats were divided into seven groups (n=10 rats/group) as follows, group1: control rats, group 2: CCL4, group 3: CCL4 that received MSCs group 4: CCL4 that received HO-1 inhibitor, group 5: CCL4 that received HO-1 inducer, group 6: CCL4 that received combined MSCs and HO-1 inhibitor , and group 7: CCL4 that received combined MSCs and HO-1 inducer. All groups were evaluated histopathologically with assessment of liver functions. The combined MSCs and HO-1 inducer group showed the highest significant results in ALT (p-value ˂0.05), albumin (p-value ˂0.05), HO-1 activity (p-value ˂0.0001), and genes expression compared to other groups.  This is due to the cumulative anti-inflammatory role of both MSCs and HO-1 together with the ability of MSCs to increase the HO-1 expression with further reduction in inflammation and fibrosis. MSCs and HO-1 inducer provide promising tool in treatment of liver disease.
    Keywords: MSCs, Liver fibrosis, HO-1 inducer, HO-1 inhibitor
  • Hossein Hamidi, Nahid Masoudian *, Mostafa Ebadi, Bostan Roudi Pages 57-65
    Lead is a toxic heavy-metal pollutant which is hazardous to human health and the environment. Sodium nitroprusside is commonly used as a nitric oxide donor in plants. Nitric oxide is a bioactive molecule playing an important role in response to stress in plants. Weight, chlorophyll content, and the activity of catalase (EC 1.11.1. 6) and peroxidase (EC 1.11.1. 7) antioxidant enzymes of canola (Brassica napus L.) Hyola 401 in lead stress were investigated. This study tested the hypothesis that sodium nitroprusside plays an ameliorating role under lead-toxicity in canola. For seven days, thirteen-day plants were exposed to two levels of sodium nitroprusside (0 and 100 µM) and three levels of lead (0, 100, and 200 µM). Dry and fresh weight and chlorophyll content were decreased in lead stress, while sodium nitroprusside treatment increased weight and chlorophyll b in the same conditions. Lead stress increased the activity of antioxidant enzymes, and sodium nitroprusside treatment reduced their activity. The results showed that the use of sodium nitroprusside reduces lead toxicity.
    Keywords: Lead, weight, Chlorophyll, Antioxidant enzymes, Sodium nitroprusside
  • Zohreh Hesari, Khatereh Kafshdoozan, Mahdi Barati, Parviz Kokhaei, Sina Andalib, Fatemeh Talebikiassari, Mahboubeh Darban, Anna Abdolshahi, Bahador Bagheri * Pages 67-74
    Cardiac hypertrophy and cardiac dysfunction are important complications of heart failure. Cardiovascular, immunological, and hormonal players are involved in the pathogenesis of heart failure. Current evidence suggests that probiotics may have fruitful effects on the heart function. This was our aim. To this end, effects of oral administration of Lactobacillus paracasei subsp. paracasei 8700:2 on isoproterenol-induced heart failure were investigated. Forty male Wistar rats weighing 200 g were randomly assigned to five groups; the control group (saline-treated group), probiotic-treated group, heart failure group (isoproterenol-introduced group), pretreatment group (treating them by probiotic for 20 days then induced heart failure) and treatment group (following heart failure-induced, treating them by probiotic for 20 days). The groups were studied for 30 days. Serum levels of atrial natriuretic peptide (ANP) and chemerin were measured by ELISA. Finally, the hearts were removed for histopathological evaluation. Compared to the control group, isoproterenol caused cardiac hypertrophy and increased ANP (P < 0.05) and chemerin levels. Treatment with Lactobacillus paracasei significantly reduced the levels of ANP (P < 0.01) and decreased the pathological damages to the myocardium. It caused a small reduction in chemerin level, as well. Pretreatment with probiotics had no positive effects on cardiac hypertrophy and related parameters. Our findings indicate that treatment with Lactobacillus paracasei subsp. paracasei 8700:2 reduces cardiac hypertrophy in rats. In addition, this probiotic reduces the serum levels of chemerin and ANP.
    Keywords: Heart failure, Atrial Natriuretic Peptide, Lactobacillus, Chemerin, Rat
  • Shiva Khalil Moghaddam *, Ashraf Sadat Shahvelayati, Atousa Aliahmadi Pages 75-80

    Ninhydrin reacts with poly-phenols in different ratios to produce tetracyclic adducts. Here, pyrogallol was used as a polyphenol compound. In the company of acidic ionic liquid (AIL), there was a selective reaction between the ortho-site of polyphenol and the ninhydrin’s carbonyl group. Mono-adduct (1:1) 3 and bis-adduct (2:1) 4 were prepared as a solvent and a catalyst for the reaction of ninhydrin with pyrogallol in 1-(carboxymethyl)-3-methyl-1H-imidazolium chloride (mcmimCl). Purity of the products was approved by 1H NMR, 13C NMR, IR and Mass Spectroscopy. Moreover, the antioxidant activity of novel derivatives investigated in this paper by 2, 2-diphenyl-1-picrylhydrazyl (DPPH) radical assay and butylated hydroxytoluene (BHT) was considered to be standard. The results indicated that mono-adduct showed the strongest antioxidant activity (IC50 = 5.289µg/ml).

    Keywords: Ninhydrin, Pyrogallol, Mono-adduct, Bis-adduct, Acetic Ionic Liquid, Antioxidant