International Journal of Cancer Management
Volume:13 Issue: 7, Jul 2020

 Pain is a common symptom associated with cancer and its treatment. The conventional treatment does not often relieve cancer pain optimally. The complementary therapies are increasingly used as adjunct therapy alongside pharmacological and conventional treatments in patients.

The aim of this systematic review was to investigate the existing evidence for reflexology effect on cancer pain through a meta-analysis.

In this systematic review, electronic databases including MEDLINE, EMBASE, Cochrane Central Register of Controlled Trials, and PubMed were searched to find relevant studies until December 2018.

We included before-after studies and trials of interventions that focused on pain management using reflexology modality as an intervention in patients with cancer regardless of cancer type. The effect of reflexology for patients with cancer pain was investigated as the main outcome.

The extracted information included name of authors, year of publication, study location, type of study, sample size, and outcome indicator. Consensus was reached by discussion in case of disagreement during each stage of selection, qualitative assessment, and extraction of data. We assessed heterogeneity using the I2 statistics. The publication bias was explored using the Egger’s and the funnel plot. We meta-analyzed the data and reported the standardized mean difference (SMD) with 95% confidence intervals (CI) using the random-effects model. Meta-analysis was done using the Revman software.

Eight studies with 948 participants were analyzed using a random- effects model meta-analysis. Included studies consisted of five randomized clinical trials, one quasi-experimental, and two pre-post design. We observed a positive effect for reflexology in patients with cancer pain compared with usual care (SMD- 0.55 [95% CI-0.82 to 0.21] P < 0.001).

This systematic review provides sufficient evidence for the effectiveness of reflexology as an effective treatment in cancer pain. But we recommend conducting studies with larger sample size, well-designed trials with sufficient duration and longer follow-up periods with clear details about reflex practitioners, duration of intervention, instrument for pain assessment, and outcome. Meanwhile, patients should be adequately monitored and adverse effects should be reported. All of the aforementioned issues might affect the impact of reflexology adjuvant treatment.

Prostate cancer (pCa) is the most frequently diagnosed visceral cancer among men. The main role of radical prostatectomy and external-beam radiation therapy (EBRT) in the management of patients with localized pCa has been established.

This study aims at comparing the clinical outcomes of hypofractionated versus conventional EBRT in the definitive management of patients with localized pCa.

From 2013 to 2019, a consecutive series of patients with localized pCa was treated with conventional (74 Gy at 2 Gy fractions) or hypofractionated (70.2 Gy at 2.7 Gy fractions) radiotherapy schedules, using 3-dimensional conformal radiation therapy (3D-CRT) and intensity-modulated radiation therapy (IMRT), respectively. The impact of the fractionation schedule on biochemical or clinical relapse-free survival (bc-RFS) and overall survival (OS) was assessed.

The median follow-up was 42 months (range: 8 - 81 months). Among 170 patients, 81 were treated with conventional and 89 with the hypofractionated schedule. The patient characteristics between groups were comparable. The mean bc-RFS of patients in conventional and hypofractionated groups was 34.9 and 35.4 months, respectively (confidence interval (CI) 95%: 34.5 - 35.7, P = 0.25). Accordingly, the mean OS of patients in conventional and hypofractionated groups was 34.6 and 38.6 months, respectively (CI 95%: 37.3 - 38.6, P = 0.04). The sub-analysis showed that the OS benefit of hypofractionated schedule was limited to intermediate- and high-risk groups with a trend toward significance (CI 95%: 0.02 - 1.46, P = 0.054).

Hypofractionation had OS benefit over the conventional schedule for definitive radiotherapy of localized pCa. This benefit was limited to patients with intermediate- and high-risk pCa.

Head and neck cancers (HNC) constitute the sixth common type of malignancies worldwide and can affect a wide range of anatomical regions. The role of the herpes simplex virus (HSV) in oral squamous cell carcinoma (OSCC) has been previously investigated.

The objective of the current study was to evaluate the molecular epidemiology of herpes simplex virus types 1 and 2 (HSV-1 and HSV-2) in patients with HNC.

A total of 156 patients with HNC were chosen including 90 biopsies and 66 formalin-fixed paraffin-embedded (FFPE) samples. HNC was confirmed and affected different anatomical regions. HSV detection was performed by a polymerase chain reaction (PCR) and HSV typing was assessed by a multiplex PCR.

The 156 HNC specimens included 35 (22.4%) larynx, 29 (18.6%) tongue, 6 (3.8%) glands (parotid and tonsil), 12 (7.6%) nasopharynx, 9 (5.7%) pharynx, 33 (21%) vocal cord, 3 (1.9%) palatine, glottis 17 (10.8%), nasal 2 (1.3%), mandibular 4 (2.5%), lip 4 (2.5%), neck 1 (0.6%), and face 1 (0.6%). The mean ± SD of the patients’ age was 60.3 ± 12.65, where 121 (77.1%) were male. The HSV was detected in 4 (2.6%) samples and 75% of HSV positive samples were HSV-1.

The rate of HSV infection in Iranian patients with HNC was 2.6% with the majority being HSV-1 (75%). As a preliminary study in Iranian patients with HNC, cancer location was not statistically significant. Further investigations are needed to assess the role of HSV in HNC.

Medical compliance plays an essential role in the control of cancer and psychological factors such as metacognitive beliefs, positive psychology, and coping styles which are among the predictors of medical compliance.

The aim of this study was to determine how much metacognitive beliefs, positive states of mind, and emotional approach coping can predict medical compliance in patients with breast cancer.

This was a descriptive correlational study. By available sampling method, 154 women with breast cancer who were medically treated and had inclusion criteria, responded to the Morisky Medication Adherence scale (MMAS), Metacognitive Beliefs questionnaire (MCBQ), Positive states of mind (PSOM) scale, and emotional approach coping (EAC) scale. Stepwise multiple regression analysis by SPSS statistics version 24 was applied for data analysis.

There was a significant correlation between positive states of mind and metacognitive beliefs and between emotional approach coping with medical compliance (P < 0.05). Positive states of mind and metacognitive beliefs were the best predictors of medical compliance (P < 0.001), while the emotional approach coping could not predict medical compliance. Results also showed that positive states of mind (β = 0. 51) have the greatest predictive power to medical compliance, and the variable of emotional approach coping is not effective in predicting.

Research findings suggest that positive states of mind and orientation toward metacognitive beliefs can control anxiety among patients and predict medical compliance in patients with breast cancer but research about emotional approach coping needs to more investigation.

Laryngeal cancer is one of the most common head and neck cancers for which total laryngectomy is the preferred treatment in advanced stages. Major disabilities of this surgical procedure include loss of voice and nasal function, swallowing difficulties, and psychological consequences.

This study aimed to investigate the effect of the Polite Yawning technique on olfactory quality in patients undergoing total laryngectomy.

In this cross-sectional study, after total laryngectomy, the patients with olfactory dysfunction were enrolled and the quality of olfaction was evaluated by the Quick Odor Detection test before and after receiving the Nasal Airflow Inducing Maneuver technique training. Statistical analysis was performed using SPSS 21 software by the Wilcoxon or McNemar’s test. The significance level was considered for P ≤ 0.05.

A total of 40 patients were evaluated. The mean age was 55.98 ± 6.27 years. Eighty-five percent of the patients were male (n = 34). The difficulty score in learning maneuvering was 2.5 ± 1.3, and 90% had no problem with learning it. Before maneuver, none of the patients had normal olfaction and had hyposmia mostly (n = 32, 80%). Immediately after the maneuver, there was a sensation of smell in all patients and the rate of hyposmia in patients was reduced to 65% (P = 0.008). Normal olfactory status was reported in half of the patients one month after the maneuver (21 patients, 52.5%, P = 0.0001), and there was a sense of smell in all patients (P = 0.0001).

The results proved that olfactory quality can be rehabilitated after laryngectomy by the nasal airflow-inducing maneuver (the “Polite Yawning” technique). It is a patient-friendly method; however, a single training session is probably insufficient and most patients may need more training sessions.

Hospitals are one of the most important units in providing healthcare services. The assessment of the quality of provided services is essential in these settings. Patient satisfaction is one of the key indicators of service quality in healthcare organizations.

This study aimed at investigating the gap between the perceptions and expectations of service recipients in Shohada-e-Tajrish Hospital (Tehran, Iran), using the SERVQUAL model in 2020.

This cross-sectional study was conducted on patients with cancer, who were upon discharge from Shohada-e-Tajrish Hospital. Patients (> 18 years) with a cancer diagnosis, who were being discharged from the oncology ward of the hospital, were included in this study. The sample size was estimated at 118. The required information was collected, using the modified SERVQUAL questionnaire. Statistical analyses were performed in SPSS version 20, using a paired t test and one-sample t-test.

The results showed that the quality of the provided services from the patients’ perspective was significantly lower than their expectations. The mean gap between the expectations and perceptions of patients was significantly above zero (P < 0.001). The most influential factor in improving patient satisfaction with the quality of services was assurance, followed by reliability, while the least effective factor was empathy. The correlation coefficient between the general status of provided services from the patients’ point of view and loyalty was 0.740 (P < 0.001).

The findings of the present study indicated that patient expectations were higher than their satisfaction. Therefore, hospital authorities should take major steps to improve the quality of services, especially reliability and responsiveness, through proper planning, prioritization of services, and review of processes contributing to patient expectations. The existing gaps can also be addressed by considering the perspectives of patients as the clients of healthcare organizations.
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