مجله علوم پزشکی پارس
سال هجدهم شماره 4 (پیاپی 54، زمستان 1399)

Kimura (KD) is a rare and chronic inflammatory disease that causes subcutaneous swelling and lymphadenopathy for unknown reasons and usually shows masses such as painless subcutaneous tumors in the head and neck. The disease is diagnosed based on the presence of a characteristic subcutaneous mass, elevated peripheral blood eosinophilia, IgA E levels, and biopsy, which indicates abnormal proliferation of lymph follicles and vascular endothelium with eosinophilic infiltration.

The patient is a 35-year-old woman who suffered from first degree localized burns in a large area of ​​the body with warm water 2 months before the diagnosis and then the symptoms of Kimura disease appeared in order and after performing several tests and sampling of the disease Proved.

It seems that in our patient, a large superficial burn acted as a skin shock and caused the symptoms of Kimura disease, so that the patient showed all the symptoms of this disease within 2 months, including skin symptoms (Dryness, burning, thickening, severe itching and excessive wrinkles), skin rashes on the back of the neck and then swelling in the nose and back of the eyes, and finally an almond-sized mass on the right side of the back Is the neck. The patient has heartburn, loss of appetite and weight loss. His illness has also responded to steroid treatment.

One of the most common complications after intrathecal anesthesia is chills during surgery. The second most common complaint followed by intrathecal anesthesia is nausea and vomiting. The aim of this study was to evaluate the effect of adding fentanyl to bupivacaine on chills and vomiting nausea in patients undergoing femoral surgery

This randomized double-blind clinical trial study was performed on 40 patients aged 18 to 50 years with anesthesia classes 1 and 2 who were candidates for femoral orthopedic surgery. Patients were randomly divided into two equal groups. The intervention group received 12.5 mg bupivacaine (2.5 cc) and 10 mg fentanyl (control group) and the control group received 12.5 μg bupivacaine (0.5 ml normal). Patients with dry mouth, nausea, vomiting and shivering were evaluated at 1, 2, 6, 12 and 24 hours after surgery. Data analysis was performed using SPSS software version 21 and descriptive and inferential statistical tests.

Forty patients undergoing spinal orthopedic surgery with spinal anesthesia participated in two equal groups (bupivacaine-fentanyl (n = 20) and bupivacaine (n = 20). There was no significant difference between fentanyl and bupivacaine in terms of recovery from nausea and postoperative times (p> 0.05) and differences between bupivacaine-fentanyl and bupivacaine in shivering at 6, 12, 18 and 24 hours postoperatively. There was no significant (p> 0.05).

In the present study, although fewer complications such as shivering and nausea and vomiting were reported within minutes of the study in the fentanyl group, this decrease was not statistically significant.

Gastric adenocarcinoma is the second leading cause of death from cancer worldwide. In this study, the effect of citric acid on p53 and p21 genes expression of the human gastric Adenocarcinoma cell line (AGS) examined. Citric acid is a naturally organic acid that considered as a physiological inhibitor of enzymes involved in glycolysis pathway to remove cancer cells.

AGS cells with different concentrations of citric acid (400, 800 and 1600 μg / ml) to examine the expression of genes P53 and p21 were incubated for 24 and 48 hours. Then, the expression of p53 and p21 genes were analyzed by Real Time PCR.

The results of this study indicate that treatment with citric acid increased the expression of p21 and p53 genes in the experimental groups compared to the control group. over expression of p53 gene at concentrations of 1600 and 800 μg / ml, respectively, was significant at 24 and 48 hours incubation times in dose and time independent manner . Expression of p21 gene at both incubation times was dose- and time dependent manner.

The results indicate that citric acid can reduce the growth of gastric adenocarcinoma cells by inducing expression of genes that involved in the apoptosis pathway and preventing proliferation. Therefore, citric acid seems to be used as an anticancer agent for the treatment of gastric cancer.

Naturaly; Inhibin-A plays an important role in the reproduction, and its abnormal level can be associated with the risk of adverse pregnancy outcomes. The aim of the current study was to evaluate the effect of high level serum Inhibin-A in the first and second pregnancy trimesters on adverse pregnancy outcomes doing a systematic review and meta-analysis.

In a systematic search done in Pubmed, Embase, Magiran, Irandoc, Web of Science, Scopus, and Google Scholar in Persian and English languages since year 2000, seven articles were extracted and entered in the meta-analysis. Finally, odds ratio and confidence intervale were reported.

The current meta-analysis showed that high level of Inhibin-A incresed the odds of preclampsia (OR= 9.77, 95% C.I: 3.88-24.62); however, it did not affect on cesarean section delivery (OR= 1.06, 95% C.I: 0.80-1.41). As adverse pregnancy outcomes addressing  the fetus and new born, high level of serum inhibin A incresed the odds of low birth weight (OR=7.34, 95% C.I: 4.4-12.23), preterm birth (OR=5.18, 95% C.I: 1.89-14.17), and fetal growth retardation (OR=2.77, 95% C.I: 1.78-4.30).

High level serum Inhibin-A in the first and second pregnancy trimesters increases the odds of preeclampsia, preterm birth, fetal growth retardation, and low birth weight; however, it does not effect on cesarean section.

Animal bites are one of the health threats that can cause transmission of zoonotic diseases such as rabies to humans. The aim of this study was to determine the incidence of animal bites and related ecological factors in Jahrom county.

This retrospective descriptive study was performed on 3913 cases of people with animal bites from April 2014 to March 2016 in Jahrom county. The collected data were analyzed using chi-square test and Pearson correlation coefficient. The Cochran–Armitage test was also performed to evaluate the trend changes in the incidence rate using Winpepi software.

The mean age of the victims was 31.4 ± 1.7 years and the frequency of men (79.6%) was significantly higher than women (p <0.05). Most of the victims were from rural (56.2%) and in terms of occupation, the highest frequency was related to other (48.6%) and students (13.7%), respectively. The frequency of bites was 71.8% in day and in 72.3% of the attacking animals was dogs. The total incidence was 1,716 cases per 100,000 people. There was no correlation between average temperature, total monthly rainfall, average humidity and vegetation cover with the number of animal bites (p <0.05).

Due to the high incidence of animal bites in Jahrom, it seems necessary to perform basic measures such as training at-risk groups, strengthening the survilance system and immunization program.

Abdominal aortic aneurysm (AAA) is a local dilation of the abdominal aorta that increases the risk of rupture up to 50% of normal diameter. AAA is the leading cause of death and is the 13th leading cause of death in the United States. Aging, male gender and smoking are the most important causes of AAA. At present, there is no drug treatment to prevent the development of AAA and mortality after rupture remains high.

The patient was a 74-year-old man with hypertension, hyperlipidemia, lumbar disc, lower extremity paralysis, chronic heart disease and bladder cancer. He underwent 2 operations due to cancer with abdominal pain and a history of fainting in the previous hour at home. Is.

In elderly patients with abdominal pain with or without underlying disease, according to the symptoms and clinical examinations, the patient can be examined for abdominal aortic aneurysm and thus there will be more time to treat the patient.