Avicenna Journal of Dental Research
Volume:12 Issue: 4, Dec 2020

Incorporating antifungal drugs into liners has been proposed to treat denture stomatitis. Varnish application on tissue conditioners can decrease the porosities and irregularities, biofilm, and pathogens adhesion. In this study, we evaluated the effect of varnish application on releasing the antifungal drugs incorporated into tissue conditioners.

Pure form of nystatin and fluconazole were mixed into tissue conditioner powder separately at 5% wt/wt concentration and prepared according to manufacturer’s instruction. Then, disk-shaped specimens (5 mm in diameter and 1 mm in thickness) were prepared at 30 nystatin and 30 fluconazole specimens. Varnish (containing 50 mL of 1,1,1-trichloroethane and 3 ml of self-cured resin) was applied on the surface of 15 disks of each drug and the other specimens were used as the control group (without varnish). Next, the disks were put in agar plates cultured with standard Candida albicans and incubated for 7 days. Mean inhibition diameter for each disk was measured with digital caliper at 24 hours, 3 days, and 7 days. Each step was performed in triplicate. Data was analyzed with one-way ANOVA and Friedman, Wilcoxon, and Mann-Whitney U tests.

The mean inhibition diameter (MID) at days 1, 3, and 7 in fluconazole without varnish group was 12.63, 3.90, and 3.67, respectively; in fluconazole with varnish was 3.00, 2.50, and 2.50, respectively; in nystatin without varnish was 5.78, 3.90, and 3.87, respectively; in nystatin with varnish group was 2.50, 0.00, and 0.00, respectively. fluconazole without varnish group exhibited significantly higher MID and nystatin with varnish group had lower MID.

In this experimental study, fluconazole was more effective than nystatin. In groups without varnish, antifungal effect continued up to day 7. Using varnish in tissue conditioner can decrease antifungal effect.

Pain is one of the most common complications after tooth extraction and pain control is a crucial part of the procedure. The purpose of this study was to investigate the influence of 0.2% (w/v) chlorhexidine (CHX) gluconate mouth rinse on the severity of post-extraction pain.

A prospective, randomized, double-blind trial was conducted among 170 subjects. Subjects were instructed to rinse with 15 mL of CHX mouth rinse (study group) or placebo (control group) 0.5 to 1 hour before extraction. Post-operative pain was evaluated considering the number of taken rescue analgesics and using a visual analog scale (VAS) that each case completed 6, 12, 24, and 48 hours after the surgery. The Mann-Whitney U test was performed in this regard.

There were no significant differences between the two groups regarding demographic variables (P>0.05). The preoperative use of CHX mouth rinse showed a better performance in mitigating the perceived pain. A significant difference in the pain level (P=0.001) was found only at the 6th hour postoperatively although there was no significant difference in the pain level between the two groups (P>0.05) at all other times (12th, 24th, 48th hours). The total number of analgesics that were taken by the study group was significantly lower compared to the control group (P=0.042).

The preoperative CHX mouth rinse could be a beneficial choice for reducing pain after simple tooth extractions.

In recent years, there has been an increased tendency for using dental lasers for the treatment of soft tissue problems. The aim of this study was to evaluate the effect of low-level diode laser (980 nm) on the level of interleukin 1 beta (IL-1β) in the gingival crevicular fluid (GCF) and the incidence of initial gingivitis caused by the use of orthodontic separators.

In this randomized clinical trial, 30 patients, who were beginning a fixed orthodontic treatment without gingivitis, were randomly assigned to control and diode laser radiation (980 nm wavelength, 3 J of energy, a density of 3 J/cm2 , a power of 0.2 W, and at a distance of 1 cm away from the tissue for 15 seconds on the buccal and palatal sides of the tooth) groups. The gingival index (GI) and bleeding on probing (BOP) were measured at the beginning of the study and one week after the treatment. The level of IL-1β was evaluated using an enzyme-linked immunosorbent assay at the beginning of the study and one week after the placement of the separator. Finally, the inter-group and intra-group statistical analyses were performed using independent and paired t tests, and P<0.05 was considered as the significance level.

The evaluation of clinical variables in the entire mouth showed a slight clinical improvement in the experimental group although there was no significant difference between the two groups. No significant difference was observed between intra-group and inter-group evaluations of clinical indices in the studied specific teeth. Eventually, no difference was found between the two groups in terms of IL-1β changes.

In general, the single-diode laser radiation session is not effective in the treatment of gingivitis in patients undergoing orthodontic treatment. Thus, it is recommended to perform frequent laser radiation sessions in further studies.

Diabetes mellitus type 1 (DM-1) is associated with pancreatic beta-cell destruction, inflammatory processes, and cardiovascular disorders. C-reactive protein (CRP) and homocysteine are considered as inflammatory processes and cardiovascular disorder indicators that can be used for monitoring patients with DM-1. The present study aimed to compare the salivary levels of homocysteine and CRP of DM-1 patients with those of healthy people.

In this case-control study, 82 patients participated, including 41 DM-1 patients (case group) and 41 healthy people (control group). The case and control groups were matched in terms of age, gender, and body mass index, and 5 mL of the saliva was collected from each participant. Then, the salivary levels of CRP and homocysteine were measured for each patient. Finally, several parameters were recorded for diabetic patients, including fasting blood glucose (FBS), 2-hour postprandial glucose (2hpp), and glycosylated hemoglobin (HbA1c), as well as the duration of the disease and the type and amount of insulin injections. Eventually, data were analyzed by SPSS software using descriptive statistics, independent t-test, and Pearson correlation coefficient.

The salivary CRP and homocysteine concentration had no significant difference between patients and controls (P>0.05). There was no significant correlation between the salivary level of homocysteine and CRP and FBS, 2hpp, HbA1c, albuminuria, duration of disease, type and amount of insulin injection (P<0.05).

According to the results of the current study, the measurement of the salivary levels of CRP and homocysteine could not be helpful for monitoring patients with DM-1.

Pain and inflammation are common problems after the third molar surgery. The purpose of this study was to compare the effect of ibuprofen and intra-muscular injection or the intra-socket placement of dexamethasone on pain, swelling, and trismus after the extraction of impacted third molar.

In this triple-blind randomized clinical trial study, 72 eligible patients were randomly divided into four groups of 18 subjects. The groups received dexamethasone powder (4 mg) inside the alveolar socket immediately before flap suturing, injection in the masseter muscle (4 mg/1 mL) immediately after the suture, the ibuprofen tablet from an hour before the surgery (400 mg every 6 hours for 1 day), and placebo. Three parameters of pain severity, swelling, and trismus were evaluated on the second and seventh days after the surgery. Data were analyzed using SPSS 17. Qualitative and quantitative data were expressed as a percentage and mean ± standard deviation, respectively. Chi-square, one-way analysis of variance (ANOVA) and, if necessary, the least significant difference tests were used for intergroup comparison. The findings were significant at P<0.05

Dexamethasone groups had significantly lower pain severity (second and seventh days), swelling (second day), and maximum mouth opening (MMO, alveolar socket: second and seventh days, masseter: second day) in comparison to the other groups (P<0.05). The ibuprofen group had significantly lower levels of pain (second and 7th days) and swelling (second day) in comparison to the control group (P<0.05). There was no significant difference between dexamethasone groups in any measurement for pain, swelling, and MMO.

The findings of this study suggest that the intra-oral administration of dexamethasone may have a better effect on pain, swelling, and trismus compared to ibuprofen and has no placebo effect.

Determining the incidence and anatomic features of accessory mental foramen (AMF) in the Iranian population is of vital importance. This study investigated the prevalence and anatomic characteristics of AMF using cone-beam computed tomography (CBCT) in a selected Iranian population.

A total of 853 CBCT images from 440 women and 413 men were examined in this crosssectional retrospective study. The images were evaluated by two independent observers using reconstructed 3-dimensional, cross-sectional, and panoramic views. Several parameters were assessed, including the location of AMF relative to mental foramen (MF), size and the point of canal bifurcations, and the distance between the main and accessory canals. Finally, statistical differences in the AMF prevalence in terms of gender and direction and its location were evaluated by the MannWhitney U test (P<0.05).

The prevalence of AMF was 10.55%, which was more frequently located in the posterior inferior area relative to the main MF, and its nerve was more frequently originated from the anterior loop (P=0.001). There were no statistically significant differences in gender (P=0.26) and direction (P=0.4). The mean distance of AMF was 7.62 mm. The mean height of MF and the AMF vertical height were 13.65 mm and 52.12 mm in those with AMF on one side, respectively, and this difference was statistically significant (P=0.001). The sizes of the MF and AMF were 3.2 mm (large diameter), 2.3 mm (small diameter), and 1.4 mm (large diameter), and 1.1 mm (small diameter), respectively.

Based on the findings of the present study, the prevalence of AMF according to hemimandibular was 5.80% in the selected Iranian population. Thus, AMF might branch from any section of the inferior alveolar nerve and the mandibular canal.

This study aimed to determine the impact of laser radiation on the repair bond strength of dental composite restorations by gathering, assessing, and systematically reviewing previous articles referring to this issue.

Several previous studies relevant to the objectives of this research were found in PubMed, Scopus, and Web of Science databases. All prior articles indexed in these databases according to the selected keywords until 2018 were gathered and assessed. Some article abstracts showed the necessary basic conditions for inclusion in the study. Therefore, the full texts of these relevant articles were further evaluated in terms of the study objectives.

A total of 300 relevant articles were obtained by searching the databases. Eight studies remained highly relevant after performing a title review, eliminating the duplicate articles, and implementing the selection criteria. The latest study was conducted in 2018. A statistically significant difference was observed between the impacts of laser and other methods in the seven of these final relevant studies. Of these articles, five indicated a better impact in the case of other methods, particularly the dental milling technique, and one study was related to the impacts of the laser method. Additionally, the Er,Cr: YSGG laser was considered the most adequate laser in these studies.

According to the review of prior studies on the impact of laser radiation on the repair bond strength of composite restorations, Er: YAG and Er,Cr: YSGG lasers are advised for surface preparation of composites. However, surface preparation by adopting the milling technique remains the adequate choice for repairing composites.