Archives of Clinical Infectious Diseases
Volume:17 Issue: 6, Dec 2022

 Helicobacter pylori is a pathogenic bacteria found in the gastric mucosa of both children and adults. Our goal was to use an endoscopic method to look at the prevalence of H. pylori in children with gastrointestinal complaints.

 This cross-sectional research was conducted in 2022 on pediatric patients who received gastric or duodenal biopsies by endoscopy. We collected data from medical reports regarding patients' age, gender, location of residence, type of gastrointestinal problems, and frequency of H. pylori infection.

 A total of 2030 pediatric patients participated in the study. Helicobacter pylori infection was found in 259 cases (12.76%). There were no significant differences between the two genders regarding the prevalence of H. pylori infection (P = 0.094). This infection was more common in patients aged > 10 years (P < 0.001) and in residents of the Isfahan suburb (P < 0.001).

 In comparison to other locations, we found a similar incidence rate of H. pylori infection in children. According to our findings, greater ages are associated with a higher detection rate of H. pylori infection.

 The Turkestan region of Kazakhstan is the natural focus of the Congo-Crimean hemorrhagic fever (CCHF). Every year, some of the patients treated in hospitals are not included in official statistics and remain in the group of possible cases of CCHF.

 This study aimed to verify the genotypes of the CCHF virus (CCHFV) in the Turkestan region and Shymkent City.

 Twelve blood samples from patients with CCHF were studied, the diagnosis of which was verified on the basis of positive specific immunoglobulins IgM to the virus. To isolate viral RNA, we used a special MAGNO-sorb kit. To detect RNA, CCHFV was used with a set of Amplisens CCHFV-FL by real-time polymerase chain reaction (PCR) using a Rotor-Gene Q device. For the reverse transcription reaction, we used a set of Reverta-L.

 The study of the genome sequence of CСHFV from GenBank demonstrated that isolates from the Turkestan region belonged to genetic groups Asia-1 and Asia-2.

 For the first time in Kazakhstan’s history, a phylogenetic analysis of RNA sequences of viruses from patients with CCHF was performed in the Turkestan region, as a result of which genetic groups Asia-1, reassortant Asia-1, and Asia-2 were established.

 Pregnancy and childbirth do not increase the risk of COVID-19 infection, but the clinical complications and worsening are more severe than in non-pregnant women.

 The aim of this study was to determine the clinical epidemiology of mothers with COVID-19 hospitalized in Ardabil province.

 In this cross-sectional descriptive study, the medical records of 20193 women of childbearing age from March 2020 to August 20 were reviewed. Gestational age, cause of hospitalization, the trend of disease and pregnancy, and possible and non-obstetric complications were evaluated. Data were analyzed by using statistical tests in SPSS version 21.

 In this study, 9942 childbirths were performed, of which 5965 cesarean sections, 3977 normal deliveries, 6990 preterm deliveries, and 72 women had stillbirths. Also, 73 (0.73%) pregnant women had early symptoms of COVID-19. The highest age range was 25 - 30 years, mostly in the first pregnancy (41.9%) and the third trimester of pregnancy (61.6%) and with symptoms of persistent dry cough, shortness of breath, fever, muscle pain, chills, decreased arterial oxygen saturation and they were dizzy. Among all infected mothers, 20.5% had a preterm delivery, and 8.2% had a stillbirth. 0.36% of mothers with symptoms and 0.46% of mothers were PCR positive

 Pregnant women do not show clinical periods, and the result is comparable to non-pregnant women of childbearing age when infected with SARS-CoV-2. 0.3% of pregnant mothers were infected, which is not a high rate. Complications of pregnancy, such as preterm delivery and IUFD, are more common in involved pregnant women.

 Larval stage of Echinococcus granulosus is the main cause of the hydatid cyst. Surgery, which is both aggressive and high-risk, is the most common treatment for this type of cyst. Some medicines, such as mebendazole, are also used as a complementary approach to preventing the recurrence of hydatid cysts.

 Considering the approved antiparasitic effects of sodium valproate (VPA) on some parasites, this research intended to examine the potential of VPA against protoscolices and hydatid walls.

 Liver hydatid cysts caused by E. granulosus were collected from a slaughterhouse. Protoscolices and hydatid cysts were exposed to RPMI and dimethyl sulfoxide (DMSO) media (control groups) or different concentrations of VPA and mebendazole in vitro. The viability of protoscolices was evaluated via light microscopy. Also, tissue changes and expression of apoptotic caspase-3 were examined in hydatid cyst walls (HCWs) using histological and immunohistochemical methods, respectively.

 The mortality rates of VPA-treated and mebendazole-treated protoscolices were dose- and time-dependent. There was a significant difference between the intervention and control groups (P < 0.05). Tissue changes and apoptosis were observed in VPA-treated and mebendazole-treated HCWs.

 Valproate and mebendazole had significant effects on protoscolices and HCWs, although VPA exerted its effects more rapidly. It seems that VPA can be a new promising protoscolicidal agent and anti-hydatid medicine.

 The new pandemic of coronavirus disease 2019 (COVID-19) has evolved certain neurologic syndromes as a presentation of this disease that should be integrated into the whole disease process.

 We present cases of neurologic involvement in adult patients with documented bronchopulmonary COVID-19. Certain signs and symptoms are introduced, including new onset seizures, ischemic stroke, and altered mental status in otherwise minimal clinical signs and symptoms of COVID-19.

 Many neurologic presentations are diagnosed in resolving COVID respiratory infections or in an otherwise asymptomatic individual.