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Medical Hypotheses and Ideas - Volume:5 Issue: 5, 2011

Journal of Medical Hypotheses and Ideas
Volume:5 Issue: 5, 2011

  • تاریخ انتشار: 1390/04/20
  • تعداد عناوین: 8
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  • Reinhard Stindl Page 1
    There have been several reports of a significant positive correlation between paternal age and chromosome telomere length in offspring. Moreover, the telomeres in sperm cells of older men tend to be longer than in young men, and it has been concluded that telomeres lengthen in the testes during adulthood. This would be the first evidence of an increasing biological advantage with age, and therefore contradicts current models in which telomere shortening is a biomarker of aging. Instead, an alternative model of telomere erosion between human generations is discussed in which longer germ cell telomeres in old men result from their being members of a previous generation. Based on the well-known correlation between maternal age and the incidence of aneuploid pregnancies, it is hypothesized that telomere erosion predominantly operates in the female germline, leading to a carry-over effect for both sexes into the next generation. This theory fits well with experimental results that maternal age does not correlate with longer telomeres in offspring. An experimental design is presented to distinguish be-tween the two possible scenarios leading to old fathers with long-telomered offspring - namely lifetime lengthening in the testis versus transgenerational germline erosion. Consideration of net loss of telomeric DNA between human generations is supported by recent findings of a large difference in blood telomere length between different Euro-pean populations of the same age, and is likely to have profound consequences for species evolution.
  • Alireza Ghaffariyeh, Nazafarin Honarpisheh, Akbar Karkhaneh, Fuad Abasov Page 2
    There is no available method for evaluating cutting quality of vitreotomes. The available methods of assessment allow only indirect judgment of their quality and are difficult to apply in clinical practice. We propose using a collagen film with maximum thickness of 1-2 micron to test the sharpness of instruments under conditions resembling clinical ones. The collagen film is fixed by a special device, then place in physiological saline, and then cut under the operation microscope. It shows whether the cutting edges are sharp enough, and the collagen film is cut smoothly. We also use an Electroforce 3100 machine and Dynamic Mechanical Analysis software to quantify the vitreoretinal force applied to the retina during vitrectomy.
  • Aswini Dutt. R., Ns Satish Kumar, Sandhya K. Hemraj Page 3
    Jasmine flower belonging to Oleaceae family is cultivated in temperate places across the globe which has more than 200 species. This flower has traditional, religious, social, spiritual and medicinal benefits. It is considered as symbol of beauty, deep affection, happiness and elegance. It is the National flower of many countries. Due to its charming fragrance, it is extensively used in perfume industry. The vital ingredient of jasmine aroma is due to the amalgamation of phytochemicals and alcoholic compounds. In India these flower strings have special importance among the fairer gender. In South India, strings of Jasmine flower are worn by lactating women. It is believed to produce increased lactopoiesis and prolong the lactational amenorrhoea. The mechanisms can be the activation of olfactory area by olfactory nerve or stimulants crossing blood brain barrier triggering a neuroendocrine response
  • Viroj Wiwanitkit Page 5
    I read the recent publication “Consumption of stressed milk resulting in stressful child” by Kumar et al. published in recent issue of Irn J Med Hypotheses Ideas with great interest and some thoughts raised. If the idea is valid then chronic exposure to such abnormal levels of cortisol would also lead to defective brain growth and then whole body would overreact to normal levels of stress hormones later in their life [1]. I agree that stressed milk might result in stressful child but the topic to be discussed is whether it can result in stressful adult. There are many facts to be considered. First, the lactating is usually limited within the first year of life; therefore, the chronic exposure might not be valid. Second, the mentioned substance such as hormones can be excreted from the body and it isvery hard to have a very long-term effect. Third, the more importance thing might be the style of child care of the parents that might be the main environmental factor that leads to stressful adult.
  • Alireza Ghaffariyeh, Nazafarin Honarpisheh, Mohammadreza Ghorbani Khebreh, Fuad Abasov, Mohammad Hossein Heidari Page 6
    Nonarteritic anterior ischemic optic neuropathy (NAION) is one of the most widespread visually disabling diseases in the middle-aged and elderly population. The optic nerve damage appears to result from a perfusion insufficiency in the short posterior ciliary arteries leading to infarction of the retrolaminar portion of the optic disc. Induced Heat shock protein (Hsp) is known to have neuroprotective effects against ischemic injury of the central nervous system in mammals. Transpupillary thermotherapy (TTT) application to the optic nerve head induces Hsp70 expression. We hypothesize that Transpupillary thermotherapy (TTT) could be a novel method for improving and preserving the function of the optic nerve fibers in the eye with NAION. An 810-nm diode laser beam is focused to the center of the optic nerve head to induce Hsp. Controlled prospective and randomized clinical trial is necessary to confirm conclusively the effectiveness of this method.
  • Ns Satish Kumar, R. Aswini Dutt, Pp Jagadish Rao Page 7
    Various factors lead to stress in human beings which have a physical component and psychological component. These factors can be from the environment or from within the body. We propose a hypothesis that there is a third element where the stress factors can be transmitted from stressed lactating mother to their babies through breast milk. The babies thus exposed to high levels of stress hormones viz., cortisol display symptoms of stress. Chronic exposure to such abnormal levels of cortisol also lead to defective brain growth and the whole body overreacts to normal levels of stress hormones later in their life.
  • Alireza Ghaffariyeh, Nazafarin Honarpisheh, Fuad Abasov, Mohammad Hossein Heidari Page 8
    Glaucoma is a significant public health problem worldwide, defined by a typical appearance of the optic nerve head and visual field defects. The most common type of glaucoma is Primary Open Angle Glaucoma (POAG). Glaucoma has been reported to be the second most common cause of visual loss in the world, and a worldwide upsurge in POAG prevalence is expected by 2012. According to numerous population-based studies, the rate of undiagnosed cases of glaucoma is more than 50%. The current unsatisfactory situation with early diagnosis and protection against glaucoma has motivated us to look for new solutions. Our method can rapidly detect suspected glaucoma. Any increase in perimetry threshold after stress test would be considered positive and high risk for glaucoma.