مجله زنان مامائی و نازائی ایران
سال هجدهم شماره 145 (هفته سوم اردیبهشت 1394)

P53 is mutated in more than 50% of solid tumors and has been changed in 30-40% of endometrial cancer which is the most common malignancy of the genital tract of women and this change is associated with papillary serous cell type and advanced stage and poor prognosis. In addition، the overexpression of BCL2 and tumor angiogenesis is important in the prognosis of patient. Therefore، this study was performed with aim to evaluate the expression of BCL2 and P53 and angiogenesis in endometrial cancer and its relationship with clinicopathological characteristics and the factors affecting the prognosis of disease.

In this retrospective longitudinal study which was performed during 2005-2014، 30 files of patients with endometrial cancer in three different hospitals (Imam Reza، Ghaem، Omid) were collected. The pathology samples were immunohistochemical staining in terms of Bcl2 and P53 markers and angiogenesis and the association of these markers with factors affecting the prognosis and recurrence of disease were investigated. Log rank، t-test and Chi-square tests were used to analyze the data and P.

P53 expression was positive in 9 cases of 10 patients (90%) with non-endometrial cancer and all patients (100%) were negative in terms of Bcl2 and angiogenesis was severe in 8 cases of 10 patients (80%) with non-endometrial cancer and in 6 cases of 20 patients (30%) with endometrial cancer. There was significant relation between tumor histology and tumor grade and stage of the disease and survival (P = 0. 002).

Since there is relationship between genetic markers with stage and grade of disease and also survival of the patients، it is better that the related block be evaluated in terms of these markers at the time of pathological diagnosis of endometrial cancer.

Micronutrients deficiency is one of the basic problems of community health in many developed countries. Children and pregnant women are at greater risk. This study was performed with aim to investigate the relationship between micronutrients of zinc، iron، selenium and folic acid in active and inactive pregnant women with their neonates'' physical development.

This prospective cohort study was performed on All pregnant women 16-35 years old، admitted to Mashhad government hospitals for birth control in 2012-13. 5 cc blood samples were taken and sent to specialized laboratory. Maternal physical activity was measured by Shark Activity questionnaire. After the birth of newborns، by referring to the medical records of mothers، their neonates'' height، weight and head circumference was obtained. Data analysis was performed by SPSS software (version 11. 5).

There was a significant correlation between the zinc concentration of inactive mothers and neonates'' weight (r=0. 52، p=0. 02)، but no relation was found between height and head circumference of newborns with micronutrients of Iron and folic acid and selenium in active and inactive mothers (P>0. 05). Growth factors of newborns of active mothers were higher than inactive mothers، although the difference was not statistically significant (P>0. 1).

The zinc micronutrient can be effective on the increase of neonates'' weight. Also active mothers have babies with better growth factor.

Cervical cancer associated with Papillomaviruses has been suggested as the most common cancer and a big problem around the world، especially in developing countries. Different genotypes of Human Papillomaviruses (HPV) especially high risk genotypes are considered as the main cause of this cancer and other human cancers such as genital track، skin، head and neck and etc. This study was performed with aim to increase the awareness about the structure، pathogenesis and diagnosis of papillomaviruses. In this review study، valid internal and external databases and the related keywords were used. In this study، it has been tried to use the published article in these scientific databases and evaluate the role of different Papillomaviruses genotypes in causing infections such as cervical cancer and diagnostic methods for genotyping of these viruses. Increasing knowledge about the important and basic role of Papillomaviruses in causing cancers will lead to improvement of novel molecular diagnostic methods along with molecular biomarkers in genotyping of Papillomaviruses. Increasing rate of genital infections، sexually transmitted diseases and cancers caused by micro-organisms، especially HPV demands the cooperation of international communities to do more comprehensive studies، especially in developing countries. Public education، development of classic screening along with diagnostic novel methods will be the best tool to determine the policies in medical and preventive strategies such as vaccine against the cancers related to Papillomaviruses.