فهرست مطالب mehrzad shabani

Heat shock protein 70 (HSP70) and lon protease 1 (LONP1) are thought to be indicators of mitochondrial stress, which is essential for cell survival. This study aimed to investigate the effect of endurance exercise on changes in HSP70 and LONP1 in diabetic mice.

This study was experimental and thirty adult mice were randomly and equally divided into three groups: control (C; n=10), diabetic (D; n=10) and diabetic-exercise (DE; n=10). Diabetes was induced by intraperitoneal injection of streptozotocin. Aerobic endurance training was performed for eight weeks. 48 hours after the last training session, glucose, insulin, HSP70 levels, LONP1 levels and insulin resistance index were measured.

Insulin, blood glucose levels and insulin resistance in group DE decreased significantly compared to group D (P<0.05). Also, HSP70 protein levels in group DE increased significantly compared to group D (P<0.05) and in group D compared to group C decreased significantly (P<0.05). A period of endurance training significantly increased the expression of LONP1 protein levels in DE group compared to group D (P<0.05). LONP1 protein levels in group D increased significantly compared to group C (P<0.05), also.

Reports show that diabetes can decreases the levels of HSP70 and increases LONP1. Also, endurance exercise can enhance impaired mitochondrial function in diabetes by increasing the expression of HSP70 and LONP1 proteins. It also improves the insulin resistance index.

Heat shock protein 60 (HSP60) is considered as an indicator of mitochondrial stress and plays a role in modulating mitochondrial dysfunction. This study aimed to investigate the effect of aerobic endurance exercise on changes in heat shock protein 60 and insulin resistance in mice with type 2 diabetes.

Thirty adult mice were randomly and equally divided into three groups: control (C), diabetic (D) and diabetic-exercise (DE). Diabetes was induced by intraperitoneal injection of Streptozotocin. Aerobic endurance training was performed five sessions per week for eight weeks. 48 hours after the last training session, glucose, insulin and HSP60 levels and insulin resistance index were measured.

Insulin and blood glucose levels and insulin resistance in group DE decreased significantly compared to group D (P<0.05). Also, HSP60 protein levels in group DE increased significantly compared to group D (P<0.05) and decreased significantly in group D compared to group C (P<0.05). Also, the results showed that there was a negative correlation between HSP60 and insulin resistance in all three groups (P= 0.001, r= 0.930).

Diabetes lowers HSP60 levels and aerobic endurance exercise increases its levels. Also, endurance exercise can enhance mitochondrial function in diabetes by increasing HSP60 protein expression. It improves the insulin resistance index, also.

Physical activity is an appropriate cost-effective means for the prevention and treatment of type II diabetes. Irisin, a recently identified myokine seems to have an important role in the transformation of white fat tissue and regulation of insulin sensitivity. The current study aimed at investigating the effect of aerobic training on serum levels of irisin and insulin resistance in women with type II diabetes.
In this semi- experimental study, 24 women with type II diabetes were objectively selected and randomly assigned into two equal groups of aerobic training and control. The exercise group undertook a 4 week (5 times a week) run aerobic exercise on a treadmill with 55-80 percent of maximum heart rate intensity. The control group did not have any physical activities. Blood samples were taken before and 48 hours after the last training session and serum levels of blood glucose and insulin were assessed. The obtained data was analyzed using paired t-test and covariance analysis. The significant level was P The Results showed significant increase in the irisin and reduce in insulin resistance and glucose in exercise group compared with the control group (P Aerobic exercise, through a favorable impact on irisin levels and insulin resistancecan act as an effective factor to improve the complications in type II diabetics.

The glucagon-like peptide-1 (GLP-1), is a neuropeptide and an incretin that helps regulate glucose and insulin concentrations. The effects of acute aerobic exercise however on the response of GLP-1 are unclear. The purpose of this study was to investigate the effect of acute aerobic exercise on glucagon -like peptide-1 (GLP-1) serum levels, glucose and insulin in women with type II diabetes mellitus.
In this study, 20 patients with type II diabetes were enrolled in two groups (experimental and control). The experimental group underwent aerobic training one times (running on treadmill) with moderate intensity 65-75% HR max to exhaustion. Blood samples before exercise, immediately after and 24 hours after exercise were collected for measuring GLP-1, glucose and Insulin.
Results showed that none of sampling time effects on GLP-1, glucose and insulin were significant (p>0.05). also, Pearson correlation showed that was significant relationship between GLP-1 changes levels and glucose (p Results indicate that in women with type II diabetes, acute aerobic exercise, with moderate intensity to exhaustion immediately and 24 hours after exercise has no effect on serum levels of GLP-1, glucose and insulin.