جستجوی مقالات مرتبط با کلیدواژه « کورکومین » در نشریات گروه « پزشکی »

Considering the high prevalence of paraquat poisoning with the intention of suicide and its extremely deadly effects on the major organs of the body, choosing the best treatment can play a significant role in reducing the mortality rate of these patients. For this purpose, this study was conducted to evaluate the therapeutic outcomes of paraquat-poisoned patients treated with a new treatment protocol.

The current retrospective study was conducted on 39 paraquat-poisoned patients treated with a new protocol. In the new protocol, in addition to the standard protocol, treatment with curcuma, pirfenidone, selenium plus, and silymarin is prescribed by gavage. By referring to the archive, basic and clinical information of these patients was extracted and recorded.

In this study, 18 (46.2%) recovered and 21 (53.8%) died. The prevalence of mortality was significantly related to the frequency distribution of gender and age of patients. Hence, the percentage of mortality was higher in men and in those over 35 years of age. In addition, in the new treatment protocol, it was found that although the administration of selenium, curcumin, and silymarin increased the chances of patients' recovery to an insignificant extent (P > 0.05), the administration of pirfenidone can significantly increase the recovery of patients (OR = 3.14 and P = 0.028).

According to the results of the present study, the administration of pirfenidone and other antioxidants can increase the recovery rate. Although the administration of silymarin, selenium, and curcumin did not show a significant relationship in terms of reducing mortality or increasing recovery, it seems that the treatment regimen based on these drugs results in a higher recovery rate.

The aim of this study was to investigate the effect of resistance training and nanocurcumin supplementation on protein amounts of NF-κB and IL-1α involved in tumor metabolism in rats with glioblastoma multiforme (GBM).

30 male Wistar rats were divided into 5 groups namely, healthy control, GBM, GBM+resistance training (RT), GBM+nanocurcumin supplement (NCUR), and GBM+RT+NCUR. GBM was injected into the frontal cortex of rats. The training group performed incremental resistance training on the ladder for 4 weeks, 3 days per week. At the end, the rats were sacrificed and the histological changes of the brain tumor were evaluated by H&E method, and also the expression of NF-κB and IL-1α protein were measured by western blot method.

Compared to the healthy control group, the GBM group showed significant tissue changes (increasing tumor area) and increased IL-1α protein levels (p≤0/05). In the analysis of tissue changes, it was found that the GBM+RT, GBM+NCUR and GBM+RT+NCUR (p≤0/05) groups showed a significant reduction in the brain tumor area compared to the GBM group. Also, the GBM+RT+NCUR group showed a significant decrease in tumor area compared to the GBM+RT and GBM+NCUR groups (p≤0/05).

It seems that, to evaluate the changes of inflammatory markers involved in tumor metabolism, longer treatment duration, different dosage of supplements, different exercise training, intensity and volume of exercise training should be used. Also, the progress of the disease can be one of the factors affecting the non-change of the molecular factors of the present study.

Physical activity with anti-inflammatory and antioxidant effects can play a critical role in the health of individuals. Therefore, the present study aimed to assess the impact of resistance training and curcumin consumption on inflammatory indicators and oxidative stress in obese men.

The present study was conducted based on a quasi-experimental design. The studied population consists of obese men aged 38-43 years. The sample size was estimated to be 40 individuals, who were randomly assigned to four groups of 10 using a random number table. The training program lasted for eight weeks, with three sessions per week. An 80 mg curcumin supplement was administered. Blood samples were collected before and after the final session. Data analysis involved one-way analysis of variance, paired t-test, and Tukey's post hoc test at a significance level of 0.05.

The amount of catalase enzyme in resistance training groups (P=0.012), curcumin supplement (P=0.032), and resistance training group with curcumin consumption (P<0.001) were associated with a significant increase. Nonetheless, it was not significant in the control group (P=0.991). Furthermore, the levels of malondialdehyde, interleukin-6, C-reactive protein, and tumor necrosis factor-alpha in the experimental groups displayed a significant decrease (P<0.05), whereas these changes were not significant in the control group (P<0.05).

As evidenced by the obtained results, it can be stated that the consumption of curcumin may be effective in suppressing the inflammation caused by obesity. This is due to its potent antioxidant effects and its combination with resistance training.

Today, cancer is known as one of the biggest public health problems and the second cause of death in the world, and due to its high prevalence, it is considered as one of the main health problems all over the world. There are many treatment strategies, including chemotherapy, to treat cancer in patients. Chemotherapy is actually the use of antineoplastic drugs alone or in combination with other drugs. Of course, these drugs can also damage the function of healthy cells and cause many side effects. Anthracyclines are one of the most widely class of drugs used in cancer chemotherapy, doxorubicin, daunorubicin, and epirubicin are among the anthracycline drug group, the most widely used of which is doxorubicin, which causes cardiotoxicity in the patients undergoing chemotherapy, and unfortunately, there is no definite and reliable treatment for it. Various strategies have been used to reduce the toxic effects of doxorubicin on non-target tissues, including the use of medicinal plants, diet and various types of long-term exercises with the aim of increasing tissue antioxidant levels. Therefore, determining the appropriate exercise and nutrition program considering the physical conditions for cancer patients who are undergoing chemotherapy treatment is so important. Therefore, the current review study aimed to determine the effects of DOX cytotoxicity on heart tissue and the benefits of regular physical activity and curcumin supplementation were investigated and discussed.

The use of curcumin with aerobic exercise is likely to be a potentially useful candidate to protect against the toxicity of blood cells caused by the drug doxorubicin, which is used to prevent the growth and progression of cancer cells in patients

Medicinal plants play a crucial role in maintaining human health and contain various phytochemical compounds recognized as therapeutic active agents. The long history of human use of medicinal plants indicates that these natural sources possess antibacterial, anti-inflammatory, sedative, and antioxidant properties. The important advantages of medicinal plants include alleviating symptoms of diseases, enhancing the immune system, and even preventing certain illnesses. Additionally, the use of various medicinal plants as an alternative or complementary approach to conventional treatments can contribute to reducing side effects and toxicities associated with chemical drugs. Therefore, further research in understanding and utilizing medicinal plants has the potential to lead to the development of innovative therapeutic methods and improve overall public health. Curcumin, the main active polyphenol component derived from Curcuma longa, can be used as a supplement to treat liver disease, cardiovascular disease, diabetes, infertility, and cancers. The therapeutic effects of curcumin consist of anti-inflammatory, antioxidant, and anti-cancer properties through direct and indirect modulation mechanisms of molecules and signaling pathways of genes involved in disease pathogenesis. Curcumin affects the expression of inflammatory cytokines, interleukins, growth factors, enzymes, adhesion molecules, transcription factors, and apoptotic proteins. In this study, a collection of reviews and research articles were searched from Internet databases and entered into the study until 2024. This study aims to investigate the molecular mechanisms of curcumin signaling pathways and clinical evidence related to its effects on the treatment of various diseases.

In this study, related materials and research resources have been prepared and compiled from library studies from Scopus, Web of Science, Pubmed, and Google Scholar databases in the last 20 years. Keywords of Curcumin, metabolism, therapeutic benefits, pharmacokinetics, signaling pathway, inflammation, and growth factors were searched in different databases. Then, the sources were evaluated and the obtained results were summarized and reported.

A wide range of studies have reported positive results about the use of curcumin in reducing the symptoms of cancers, arthritis, allergies, atherosclerosis, neurogenic diseases, liver cirrhosis, obesity, psoriasis, and autoimmune diseases and delaying the aging process. In general, curcumin can be used as a supplement besides chemical drugs. Curcumin reduces inflammatory responses and its anti-inflammatory effect is comparable to non-steroidal anti-inflammatory drugs.

Medicinal plants are very diverse and can be used to treat various diseases. Further research in the field of herbal medicines can lead to a better understanding of their effects and applications and be effective in creating new medicines. According to the current research, it seems that curcumin with multiple abilities, including anti-inflammatory, antioxidant, and anti-cancer, can play an effective role in the process of preventing and treating some diseases. However, more studies and clinical research are needed to more accurately evaluate the long-term effects and safety of curcumin consumption. In the future, the exploration of medicinal plants holds promising prospects for the development of novel therapeutic interventions, as ongoing scientific research continues to unveil the intricate bioactive compounds and molecular mechanisms underlying their medicinal properties, paving the way for innovative pharmaceutical applications and enhanced healthcare solutions.

Inflammatory gum disease is a complication of diabetes that can impact blood sugar control. Current treatments for diabetic patients, such as scaling and gum surgery, are invasive. The present study aimed to review the effectiveness of curcumin in improving periodontal lesions in diabetic patients.

Four databases of Scopus, PubMed, Web of Science, and Google Scholar were searched for relevant studies without any time or language limitations. MeSH keywords and text words related to "curcumin," "periodontal lesions," and "diabetes" were used to search in the title-abstract field. The titles, abstracts, and full text of the studies were reviewed to identify eligible studies. The present study followed PRISMA guidelines for implementation and reporting.

Finally, 10 studies were included in the review. The results showed that curcumin can reduce free radicals and inflammatory factors, improving inflammation. Gums in diabetic patients should be scaled alone or with invasive methods.

It seems curcumin may effectively reduce gum inflammation and bone loss in diabetic patients. However, to reach a reliable conclusion, further human studies are required in this field.

Apoptosis is regulated by a complex interplay of gene products that either activate or inhibit this process. This study aimed at assessing the combined impact of nanocurcumin supplementation and resistance training on TERF2 (Telomeric Repeat Binding Factor 2) gene expression and the p21-p53 axis in the muscle tissue of male rats.

In this experimental study, 24 male Wistar rats were randomly allocated into four groups: a healthy control group, a resistance training group, a nanocurcumin group, and a resistance training + nanocurcumin group. Resistance training was conducted over a 4-week period following a specific protocol. Concurrently, rats in the nanocurcumin groups received 80 mg of the supplement per kilogram of body weight. The expression levels of TERF2, p53, and p21 genes were assessed using the Real-Time PCR method.

The results showed significant differences in the expression levels of TERF2, p53, and p21 genes among the four groups (P<0.05). In the resistance training + nanocurcumin group, the expression of TERF2, p53, and p21 genes was significantly higher compared to the control group (P<0.05). Additionally, p53 gene expression in the resistance training group was significantly higher than in the nanocurcumin supplement group (P<0.05). The combined resistance training and nanocurcumin supplementation did not significantly affect the expression of the TERF2 gene in the muscle tissue of male rats compared to either training or supplementation alone (P<0.05). Furthermore, the synergistic effect of resistance training and supplementation significantly increased the expression of p21 and p53 genes (P<0.05).

Resistance training and nanocurcumin supplementation enhance TERF2 gene expression, potentially reducing telomere shortening and aging. Moreover, the upregulation of p53 and p21 gene expression during resistance training and nanocurcumin supplementation may induce cell cycle arrest and apoptosis.

Resistance to various antibiotics is one of the most problematic hospital complications and a mortality cause. Curcumin or diferuloylmethane is a strong antioxidant present in turmeric, and its antibiotic properties have attracted the attention of researchers. Also, this substance can penetrate other molecules. This research aims to investigate the synergistic effect of curcumin with three antibiotics rifampin, meropenem, and curcumin against Pseudomonas aeruginosa.

In this experimental study, curcumin was extracted at concentrations of 20, 40, 80, and 100 µg/ml. Antibiotics rifampin, meropenem, and amikacin were extracted at the same concentrations and their effect on the mean and standard deviation of the growth halo of Pseudomonas aeruginosa bacteria was investigated. Finally, a combination of antibiotics and curcumin in ratios of 75:25, 50:50 and 25:75 was made its effect on the mean and standard deviation of the halo diameter of non-growth of Pseudomonas aeruginosa bacteria was investigated. In this study, the Kolmogorov-Smirnov test was used to determine whether the data were parametric or non-parametric, and then, according to the results of the Kolmogorov-Smirnov test, the mean comparison test was used.

By increasing the ratio of curcumin and antibiotics, the mean and standard deviation of the diameter of the non-growth halo against Pseudomonas aeruginosa increased compared to the antibiotic alone (rifampin- curcumin       P-value = 0/033, meropenem- curcumin P-value = 0/006, amikacin- curcumin P-value = 0/003). Also, with the increase of the amount of antibiotic and this ratio reached 25:75 (respectively curcumin: antibiotic), the mean and standard deviation of the diameter of the non-growth halo against Pseudomonas aeruginosa increased more strongly. The        non- growth halo of antibiotics rifampin, meropenem, and amikacin alone were 8/88 ± 0.0 mm, 31/11 ± 0/1 mm,       32/29 ± 0/0 mm, respectively, and in combination with curcumin were 24/5 ± 2/8 mm, 47/6 ± 0/7 mm, 49/8 ± 1/4 mm, respectively (all P-values less than 0/05).

Curcumin has a synergistic effect on the activity of rifampin, meropenem and amikacin antibiotics, and with increasing curcumin ratio, its effectiveness increases.

Background and Objectives The present study aimed to determine the effect of curcumin and chlorogenic acid (CGA) on the survival rate of bone marrow mesenchymal stem cells. Subjects and Methods Twenty-four male mice were randomly divided into four groups of six: Control, Curcumin, CGA, and Dimethyl sulfoxide (DMSO). Around 10 μmol/L Curcumin was added to the culture medium, and the cells were exposed to curcumin dissolved in DMSO for 48 h. In addition, in the CGA group, this substance was added to the culture medium with a dose of 10 mmol (for 24 h). After isolation, culture, and passage of bone marrow mesenchymal stem cells (BMSCs), the cells were trypsinized, and then centrifuged. For cell counting, after mixing 10 μl of culture medium with cells and 10 μl of toluidine blue, the number of live and dead cells was counted.Results Exposure of stem cells to curcumin for 48 h at a dose of 10 μmol resulted in a significant increase in cell viability compared to the control group. Furthermore, the presence of mesenchymal stem cells with 10 mmol of CGA for 24 h significantly increased cell survival. Statistical analysis revealed a significant difference between the groups of curcumin and CGA in cell survival, and the effect of curcumin was more significant than CGA. Conclusion Comparison of the protective effect of curcumin on mesenchymal stem cells based on statistical analysis showed that the effect of curcumin is much greater than CGA, and a significant difference between these two treatment groups indicates that curcumin is more effective in protecting against death and increasing the live/dead cell ratio.

 Curcumin, the biologically active ingredient of turmeric (Curcuma longa), affects pain processing at different levels. Local mechanisms of action of curcumin are somewhat known, but the central effects at the spinal and supraspinal levels have been less investigated. In this study, the effect of oral administration of curcumin on the formalin-induced muscle pain was investigated. In addition, naloxone (a non-selective opioid receptor antagonist) and AM251 (a cannabinoid 1 receptor antagonist) were used to clarify the possible central mechanism of action of curcumin. 

 For intracerebroventricular (ICV) injections, one stainless steel guide cannula was implanted into in the left lateral ventricle of the brain in anaesthetized rats. Muscle pain was induced by intramuscular (IM) injection of formalin (2.5%, 50 µl) in the right gastrocnemius muscle, and the number of paw flinches and the time spent licking and biting of the injected paw were recorded at 5-min blocks for 1 h.

 A marked biphasic pain response was observed due to formalin injection. Oral administration of curcumin at doses of 25 and 100 mg/kg significantly (p < 0.01 and p < 0.001, respectively) decreased both phases of muscle pain. Pain intensity was not influenced by alone ICV injection of naloxone and AM251 (p > 0.05), whereas the suppressive effect of 100 mg/kg curcumin was inhibited by ICV administration of 2 µg naloxone and 2 µg AM251 (p < 0.001). All the above-mentioned treatments did not alter locomotor activity.

 These results showed that curcumin produced an antinociceptive effect in muscle pain. Central opioid and cannabinoid receptors might be involved in the antinociception induced by curcumin.

 Curcumin has potential anti-inflammatory effects. The aim of this study was to investigate the protective effect of curcumin against cardiac ischemia -reperfusion injury in rats fed a high-fat diet.

 In this experimental study, male Wistar rats were divided into four groups: control (C), high-fat diet (H), curcumin 100 (HyperC100, 100 mg/kg) and curcumin 200 (HyperC200), with the last two groups receiving oral curcumin daily for 3 weeks.
The rats were fed a high-fat diet for 7 weeks to induce obesity. After anesthesia, hearts were removed and placed on the Langendorff perfusion system andbegan beating. After 20 minutes of stabilization, 35 minutes of ischemia and 60 minutes of nutrient fluid reflux were performed. During this interval, ventricular (LV) functional indices including LVSP, LVDP, LVEDP and +dp/dt were recorded. The relative size of the infarction was measured by using 2,3,5-triphenyltetrazolium chloride staining.

 Hyperlipidemia caused dysfunction with changes in ventricular parameters, but curcumin could to improve some LV contractile parameters such as systolic pressure and increase diastolic pressure (P≤0.05). Curcumin could not significantly reduce the infarct size.

 Curcumin may have an cardio protection effects against ischemia/reperfusion injury in normal and hyperlipidemic rats.

Curcumin has antioxidant and anti-inflammatory activities. The aim of this study was to investigate the protective effect of curcumin on changes in the serum concentration of LH, FSH , testosterone hormones and testicular tissue induced by methotrexate in adult male rats.

In this experimental study, 30 adult male Wistar rats with an approximate weight of 230-260 grams were divided into 6 groups of 5 each. Control group, sham group: 1 ml of distilled water as a solvent, experimental group 1: methotrexate (5 mg/kg), experimental group 2: curcumin (400 mg/kg), experimental group 3: methotrexate (5 mg/kg) + curcumin (200 mg/kg), experimental group 4 : methotrexate (5 mg/kg) + curcumin (400 mg/kg). After 28 days of treatment in the form of gavage injection, blood was taken directly from the heart to measure the serum concentration of  LH, FSH and testosterone hormones. The testicles were removed and tissue changes were examined after hematoxylin-eosin staining. The data results were analyzed based on one-way analysis of variance (ANOVA) and Tukey's test.

In the group receiving methotrexate, the level of testosterone hormone, the number of spermatogonia, spermatocytes, sperm and leydig decreased and the serum level of LH and FSH increased significantly compared to the control and sham groups. In the groups receiving methotrexate + curcumin, curcumin was able to compensate the adverse effects caused by methotrexat (P <0.05).

Curcumin can improve the changes in serum testosterone, FSH, LH concentration and testicular tissue induced by methotrexate in adult male rats.

Apoptosis is a protective cellular process and physical activity and curcumin may affect some signaling pathways related to apoptosis. The aim of the present study was to evaluate the effect of high-intensity interval training (HIIT) and curcumin consumption on mitochondrial caspase 3 and 9 gene expression of cardiomyocyte in male rat of the stroke model.

In this experimental study, 32 male rats with myocardial infarction were assigned randomly into 4 equal groups (n=8) of HIIT, supplement, control, and supplement+HIIT. The HIIT groups were subjected to high-intensity interval training (10 bouts of 4-minute activity with an intensity of 85-90% of VO2max) for 8 weeks. The amount of 15 mg of pure curcumin per kilogram of body weight was given by a gavage to the supplement and HIIT+supplement groups, 5 days a week. All rats were anesthetized by intraperitoneal injection of ketamine and xylazine, 48 hours after the last training session, then surgery and dissection of the rats were performed.

The results showed a significant decrease in the expression of caspase 3 and 9 genes in the HIIT and HIIT+supplement groups compared to the control and supplement groups.

It seems that HIIT and curcumin consumptions lead to a reduction of mitochondrial apoptosis in cardiac muscle. The present findings show that the expression of caspase 3 and 9 in cardiac tissue is a trainable factor.

Background &

Inflammation is a complex physiological and pathological process. Inflammation is usually an adaptive response caused by harmful stimuli and conditions (such as infection and tissue damage) to maintain body homeostasis. Inflammation can be divided into acute inflammation and chronic inflammation. Acute inflammation lasts only a short time and is usually beneficial to the host. When inflammation continues for a long time, it becomes chronic and can contribute to various chronic diseases such as obesity, diabetes, arthritis, pancreatitis, cardiovascular, neurodegenerative, metabolic, and certain types of cancer. Inflammatory mechanisms in various diseases such as arthritis, psoriasis, depression, and atherosclerotic disease processes have attracted the attention of researchers, and high levels of inflammatory mediators have been detected in lesion sites. Inflammation makes the disease more severe and creates a vicious cycle that poses challenges to the treatment. Therefore, it is clear that inflammation plays an important role in the occurrence and development of the disease, and compounds with anti-inflammatory effects are the first therapeutic strategy to reduce the complications of inflammatory diseases and the level of inflammation. The significant anti-inflammatory activity of curcumin has attracted the attention of many researchers and is known as one of the natural compounds with the greatest potential in the treatment of diseases. Curcumin has anti-inflammatory, antioxidant, anti-tumor ,and other biological activities. It can be said that the basis of various biological activities of curcumin is its anti-inflammatory properties and it plays an important role in the treatment of inflammatory diseases. Curcumin and curcuminoids, the active components of turmeric, have been effective in the treatment of inflammatory diseases for many years. In general, the anti-inflammatory effects of drugs can be mainly listed as follows: effect on receptors and signaling pathways, regulating the response of target tissues to inflammatory mediators ,and reversing the effect of the environment on the target tissue. Curcumin has anti-inflammatory effects by regulating inflammatory signaling pathways and inhibiting the production of inflammatory mediators. Curcumin has significant anti-inflammatory effects and a large number of pre-clinical or clinical studies have investigated its effect on inflammatory diseases such as inflammatory bowel disease, arthritis, psoriasis, depression, and arteriosclerosis. Current evidence shows that curcumin is effective in reducing the levels of inflammatory mediators and the anti-inflammatory properties of curcumin may have a beneficial effect on these diseases. There are several studies that confirm the link between curcumin and reduced levels of inflammatory disease. The findings of the studies conducted in the field of medicine and paramedicine show that there are very good anti-inflammatory properties in curcumin and curcumin regulates NF-kB, MAPK, AP-1, JAK/STAT, and other signaling pathways. Curcumin controls and inhibits the production of inflammatory mediators. Considering the importance of the issue of inflammatory diseases and the effect of curcumin on this type of disease and the explanations provided, the question that is raised here is, what are the results of various studies in the field of inflammatory diseases and the role of curcumin on this condition? What has been achieved and what requirements have been recommended regarding the reduction of inflammatory diseases through curcumin?

The current study is a review study that includes articles published in domestic and foreign journals available in SID, PubMed, Google Scholar, Magiran, Springer, Wiley, Web of Science (ISI), Scopus, Science Direct, ProQuest databases. The range of years 2020 to 2022 was used. Articles were searched using the keywords "curcumin, inflammatory diseases" and their English equivalents. As a result of the initial search of articles, there were 156 articles, of which 74 articles remained in the screening stage, and at the end, 12 articles were subjected to content analysis.

This review study showed that curcumin is effective in reducing complications and improving the condition of inflammatory diseases, and curcumin, having anti-inflammatory properties, can play an effective role in improving the symptoms of these diseases.

In general, it can be concluded that to reduce the complications of inflammatory diseases, it is important to pay attention to curcumin and it is not far from the expectation that it is one of the drugs considered by researchers to treat inflammatory diseases. Administration of curcumin also reduces mRNA expression of pro-inflammatory cytokines IL-1β, IL-6, and TNF-α through IL-1β/NF-κB signaling, and inhibits NLRP3 inflammasome activation. Curcumin ameliorates IL-1β-induced neuronal apoptosis by inhibiting the P38 pathway in chronic mild stress-induced rats. The anti-inflammatory effect of curcumin is one reason for its improvement in depression, but this is not conclusive. In addition to its anti-inflammatory properties, curcumin also prevents the release of monoamine oxidase, serotonin, and dopamine, and strengthens the pituitary axis of the adrenal gland, hypothalamus, nutritional factors, hippocampal neurogenesis, and neural flexibility. Curcumin may play an anti-inflammatory role by regulating inflammatory mediators and immune cells. Curcumin is found in traditional Chinese medicine, and is prescribed to control stress and mood disorders. Curcumin has anti-inflammatory, antioxidant, and neurotrophic properties, indicating a strong potential for depression relief. Chronically unpredictable mice exposed to mild stress exhibited depressive-like behaviors and elevated levels of depression-related cytokines, a classic model for studying depression. According to the results of relevant tests, such as social interaction test, sucrose preference test, forced swimming test, open field test, curcumin treatment succeeded in correcting depression-like behavior of stressed rats.

Infertility is a disorder that affects about 15% of couples and 50% is related to male. Sperm freezing involves storing semen samples at -196°C in liquid nitrogen. During freezing, due to the induction of apoptosis through oxidative stress, the functional indicators of sperm are damaged and ultimately lead to a decrease in fertility. There have been many studies on the use of freezing environments with complementary antioxidants to limit the damage caused by freezing. In this study, melatonin and curcumin were used in combination as antioxidants in sperm freezing.

This study was conducted in 2022 on the semen of 40 men with normal sperm in Qazvin University of Medical Sciences. To check sperm motility by CASA device, morphology by hematoxylin staining, viability by eosin nigrosine staining, DNA integrity by tunnel kit and MDA measurement by reaction method with thiobarbituric acid and spectrophotometer were used. Data analysis was done using SPSS software (version 25) and ANOVA test, dependent t-test and one-way analysis of variance. P<0.05 was considered statistically significant.

The use of melatonin and curcumin either separately or in combination in the freezing environment had a significant effect on the rate of motility and survival, DNA fragmentation and MDA level (P<0.05).

Adding curcumin and melatonin in combination to the freezing environment will have a positive effect on sperm parameters after freezing.

Breast cancer is one of the most common malignancies in women. Treatment with herbal drugs has been considered by researchers due to the lower side effects. Curcumin is a polyphenol extracted from turmeric with confirmed anti-cancer properties. Curcumin is water-insoluble with rapid metabolism. Drug delivery using nano-carriers is suggested to overcome such limitations. The aim of this study was based on evaluating the effect of Dendrosomes curcumin on expression level of HOTAIR long noncoding RNA in MCF-7 breast cancer cell line.

This study was an applied basic research. Firstly, curcumin was loaded in dendrosomes and the entry of dendrosomal curcumin into cells was studied using fluorescent microscopy.  Cell death was investigated using MTT assay and apoptosis detection kit. The expression of HOTAIR gene was measured using real-time PCR. Increased expression of this gene was reported in a wide range of tumors. The data were analyzed using GraphPad Prism V9.5 statistical software, using NOVA one-way statistical analysis and Student t-test; the results were reported as mean ± standard deviation.

Dendrosomes increased the solubility of curcumin. The effective inhibitory doses of dendrosomal curcumin after 24 and 48h treatment were 25 and 20 micromolar, respectively. The percent of cells undergoing early apoptosis were 22.97±0.03 and 56.22±0.05, respectively, which was statistically significant in comparison with non-treated control cells. Following 24 and 48h treatment with 20 micromolar of dendrosomal curcumin, the HOTAIR gene expression was significantly decreased (P=0.001).

These findings suggest that dendrosomal curcumin may promote breast tumor cells toward programmed cell death by reducing HOTAIR gene expression.

Cancer is the second cause of death. The use of a new drug delivery system that can deliver the drug to the tumor site and prevent it from entering the body's natural tissues is essential. Metal oxide nanoparticles have been considered one of the effective candidates for cancer treatment. For this reason, our study was conducted to investigate the cytotoxic effect of the simultaneous use of Ag/ZnO nanoparticles and curcumin on the Michigan Cancer Foundation-7 (MCF7) breast cancer cell line.

The MTT colorimetric method was used to investigate the synergistic effects of zinc oxide silver nanoparticles and curcumin. Cells with different concentrations of zinc oxide silver nanoparticles and curcumin, including 3.9, 7.8, 15.62, 31.25, 62.5, 125, 250, 500, and 1000 micrograms/ml during 24 and 48 h were incubated in triplicate to observe the synergistic effects of each of these concentrations, ratios of 1 to 1, 0.5 to 0.5, 0.25 to 0.75 of zinc oxide silver nanoparticles and curcumin were used. The viability of the cells treated with the drug was determined in the form of the percentage of light absorption of the produced formazan and was shown in a two-dimensional curve.

The effect of Ag/ZnO nanoparticles alone on the survival rate of cancer cells had a significant difference with curcumin. In addition, in the simultaneous examination of Ag/ZnO nanoparticles and curcumin, much more cytotoxicity was observed than in Ag/ZnO alone.

In general, the simultaneous use of chemotherapy drugs and nanoparticles can decrease the concentration of chemotherapy drugs used in cancer treatment.

Methamphetamine (METH) is widely used as a psychostimulant. Neurotoxicity is one of the side effects of METH. Curcumin is effective against nerve damage due to its antioxidant and anti-inflammatory effects. In this study, we aim to assess the effects of curcumin on cognitive memory and cell death in the hippocampus of rats with neurotoxicity induced by METH.

In this study, 60 male Wistar rats were divided into the following groups: Control (n=12), negative control (n=12, received dimethyl sulfoxide), positive control (n=12, received METH), METH+100 mg/kg curcumin (n=12), and METH+200 mg/kg curcumin (n=12). Neurotoxicity was induced by 40 mg/kg METH injected intraperitoneally 4 times (once per two hours). Curcumin treatment was done for 7 consecutive days after the last injection of METH. One day after the last curcumin injection, cognitive memory in the hippocampus of rats was assessed using the object recognition test. Nissl staining was used to assess cell death. The data analysis was done in GraphPad Prism software, version 6.

Administration of curcumin with a dose of 200 mg/kg significantly reduced the cognitive impairment and increased necrotic cell death.

Curcumin can improve cognitive memory and increase cell death in the hippocampus of rats with METH-induced neurotoxicity.

Sirtuin1 is one of the important indicators involved in metabolic control, obesity prevention, and homeostasis control. This study aimed to investigate the effect of combined exercises and curcumin consumption on metabolic indices and serum levels of Sirtuin1 in men with metabolic syndrome.

The present study was conducted as a clinical trial in men with metabolic syndrome in three intervention groups and one control group. The people in the intervention group underwent an exercise program for 8 weeks and three sessions a week, the supplement group took 3 capsules of 500 mg daily. Blood factors were measured before and after the last training session. Data were analyzed by paired t-test, analysis of variance and covariance.

A significant difference was observed in the intra-group changes of the studied variables (Sirtuin1, HDL, LDL, TG, FBS, and TC) in all three intervention groups (P≥0.05). The results of analysis of covariance test showed a significant difference between the four groups in the indices (Sirtuin1, HDL, LDL, TG, FBS, and TC) after the test (P<0.05).

Combined exercises, curcumin consumption, and implementation of both interventions simultaneously positively affected the metabolic indices and serum levels of Sirtuin1 in people with metabolic syndrome.

Improving the quality of life of patients is the main goal of therapeutic interventions in chronic diseases. One way to achieve this is to decrease the severity of symptoms. The aim of this study was to investigate the effect of curcumin capsule on quality of life and symptoms of patients with irritable bowel.

This clinical trial study was performed on 60 patients with irritable bowel syndrome referred to Amir al-Momenin Hospital in Arak city from April to September 2018, using convenience sampling and Extra-intestinal symptoms severity scale and WHOQOL_BREF tools. The patients were divided into two groups of intervention and control, curcumin capsules were used in the first one, and in the second one, placebo capsules were used twice a day after lunch and dinner for four weeks. All patients were examined at the beginning of the study, the fourth week and three months later, in terms of quality of life, severity and frequency of symptoms and possible complications. During this period, the patients were followed up on a monthly basis through phone calls, and the contact number of the researcher was provided to the patients to call in case of any problems or questions.

The average age of the curcumin group was 35 years and for the placebo group was 36.43 years. There was no significant difference in the quality of life between the curcumin and placebo groups after the intervention (P>0.05). Significant were found between the curcumin and placebo groups after the intervention (P<0.05).

The results of this study showed that there was a significant difference between curcumin and placebo in improving the clinical symptoms of patients, but the quality of life of patients in both curcumin and placebo groups did not change significantly after the intervention.