Effects of Citrus sinensis juice on blood pressure and Flow Mediated Dilation

Citrus sinensis juice (CSJ) is a rich source of dietary flavonoids which reduces the risk of adverse cardiovascular events. This study aimed to examine the effects of four-week intake of natural and commercial Citrus sinensis juice on blood pressure (BP) and Flow Mediated Dilation (FMD) in healthy volunteers. In a randomized crossover study, twenty-two healthy subjects in 18–59 years old were divided randomly into two groups: A and B. The volunteers in-group A consumed commercial CSJ for 4-week at first stage and after 2 weeks washout period consumed fresh CSJ. Instead, group B volunteers consumed fresh CSJ for 4-week at first stage and they consumed commercial CSJ (500 mL/day) after 2 weeks washout period. In both groups, BP and FMD were measured at baseline and at the end of 4weeks. Data were analyzed using statistical tests: paired t-test, Independent t-test, and linear mixed model. This study indicated diastolic blood pressure (DBP) was decreased (-5.1%) and systolic blood pressure (SBP) (-5.9%) after intake of commercial CSJ significantly (P<0.05), Whereas consumption of fresh CSJ on DBP and SBP has not significantly effect, On the other hand, FMD in consumed fresh CSJ group has a significant effect (P<0.05). Between the group changes were not significantly observed for non of each factors. Consumption of natural and commercial CSJ are useful to prevent atresceloresis, but the effects of commercial CSJ was higher. Commercial CSJ includes flavonoids, pectin, essence compared to citrus sinensis juice.