A Study of the Effect of Apium graveolens Hydroalcoholic Extract on Formalin-induced Inflammation in Male Rat Hind Paw

The aim of this study was to compare the inflammatory effect of hydroalcoholic extract of Apium graveolens with aspirin. Subject and The plant was collected from Dezful gardens. Hydroalcoholic extract of Apium graveolens powder was macetrated in ethanol 70% (v/v). Animals were divided into 6 groups (10 for each). Negative group received 5ml/kg normal saline، the positive group received 300 mg/kg aspirin and extract-treated groups received 100، 200، 400، 600 mg/kg of hydroalcoholic extract of Apium graveolens (IP) respectively. Thirty minutes later all groups received 100 µl formalin 2. 5% (SC، in hind paw). Hid paw vulome was measured for five hours in intervals of one hour using plethysmometer. All extract-treated groups showed dose-dependent anti-inflammatory effect. There were no significant differences between the groups that received 400 and 600 mg/kg extract with those received aspirin. The hydroalcoholic extract of Apium graveolens showed anti-inflammatory effect that was dose-dependent.