Effect of regular exercise-induced apelin on dyslipidemia of type 2 diabetic rats

Recently the role of apelin in improvement of dislipidemia has been known. The purpose of this study was to determine the effect of regular exercise-induced apelin on dyslipidemia of type 2 diabetic rats.
Twenty eight diabetic male Wistar rats were divided into 3 groups: Non-diabetic (n=9), control diabetic (n=9) and trained diabetic (n=10). Type 2 diabetes was induced by injection of nicotinamide and streptozotocin. The aerobic training program included 8-week running on treadmill progressively for 45 min at a speed of 24 m/min and a 5% grade. After the period of training, plasma level of apelin and lipids (TC, HDL-C, LDL-C, VLDL-C, TG and FFA) were measured. One-way analysis of variance (ANOVA) was used for analyzing data and P In trained diabetic compared with control diabetic group, a significant increase in apelin, a significant decrease in plasma level of LDL-C, VLDL-C and TG, an insignificant decrease in TC and FFA, insignificant increase in HDL-C were observed.
Results of present study showed that increase in plasma level of apelin following regular exercise by inhibition of lipolysis and decrease of blood lipids can improve dyslipidemia of type 2 diabetic rats.