The effect of 14 weeks aerobic exercise on resveratrol supplementation on protein UCP-1, SIRT1, PGC-1α in liver tissue, subcutaneous and visceral fat tissue in male wistar rats
Author(s):
Article Type:
Research/Original Article (دارای رتبه معتبر)
Abstract:
The purpose of this study was to determine the effects of resveratrol supplementation and Aerobic training on protein levels of SIRT-1, PGC-1α and UCP-1 liver tissue and abdominal & inguinal subcutaneous adipose tissue in adult male Wistar rats. In this study, 28 male rat (w=260흈, 8 weeks) divided into 4 (n=8) groups: control (C), aerobic training (T), complement-training (T-R) and supplements (S) randomly. Training groups exercised for 14 weeks (5 sessions a week, each session 45 minutes on a treadmill. ELISA (sandwich double) was used to measure tissue proteins UCP-1, SIRT1, PGC-1α. ANOVA test used for data analysis and statistical significance (p≤0.05) were considered. SIRT1 and PGC-1α protein was observed changes in liver tissue and subcutaneous / visceral white adipose tissue, respectively (P≤0.05) and (P≤0.001). Increased protein UCP-1 is also measured in tissues-workout supplement after supplement in combination with aerobic activity (P≤0.001). According to our results, are likely to impact more powerful, resveratrol supplementation with aerobic physical activity increases the amount of UCP-1, SIRT1, PGC-1α tissue to separate than from physical activity or resveratrol supplements, And is likely to Improved liver function and change subcutaneous white adipose tissue to beige or intermediate phenotype.
Keywords:
UCP-1 , SIRT1 , PGC-1? , Aerobic training , Resveratrol
Language:
Persian
Published:
Sport Biosciences, Volume:10 Issue: 36, 2018
Pages:
39 to 58
magiran.com/p1860052
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