The effect of Magnesium Sulphate vs Dexmedetomidine on opioid consumption in opium abusers undergoing surgery with spinal anesthesia

chronic opioid abuse might be led to poor pain control and need of high dose of analgesic drug in postop surgery. The research has been demonestrated that duration of spinal anesthesia is lower in opium abusers than other patiants therefore it might result in more demand for pain killers, morbidity and hospital stay. As we know Dexmedetomidine and Magnesium Sulphate have been the medicines used to control pain; in this study the propable effect of IV injection of these 2 medicines on opium consumers who had been under spinal anesthesia has been assessed intraop and postop surgery. In clinical trial, 150 male opium abusers (ASA class 1, 2) after matching features were randomly allocated in three groups (A: Dexmedetomidine, B: Magnesium Sulphate, C: Control). The percentage of first time pain killer requests of the patients in need of Intraop fentanyl, in the recovery room and complication were compared within three groups. Results show that percentage of the Patients in need of Intraop fentanyl in group A was 13/6%, B22/7% , and C was 63/6% (P=0/005). The first time request of opioid from 0-180 min postop displayed a statistically significant difference between three groups. (P=0/001) IV injection of Dexmedetomidine and Magnesium Sulphate Reduced Intraop and postop opioid consumption and delayed the first time request of opioid in recovery room and significantly reduced VNRS in group A, B compared with control group.