Synchronized effects of aerobic training and magnesium supplementation on cardiometabolic risk factors and A1c in Type 2 diabetic females

Nowadays the effect of physical exercise on diabetes control improvement is evident and the both insulin release and function depends on magnesium (Mg) and Mg even improves insulin sensitivity. However; diabetes causes hypomagnesiumemia which in turn worsens glycemic control in a viscous cycle. Likewise; little is known about the synchronized effects of exercise training along with Mg supplementation on diabetes control. Therefore; the aim of this study was to investigate the synergistic effects from eight weeks of aerobic training and magnesium supplementation on metabolic control, blood insulin and glycosylated Hb (A1C) and Mg levels in female patients with type II diabetes. This study was done based on an experimental method using a pretest-posttest design. Thirty volunteer midlife type II diabetic females were randomized into training-Mg, training-placebo and control groups.  The subjects consumed magnesium oxide or amylose containing pills (250 mg) once daily in a double blind order for eight weeks. The training groups also experienced eight weeks of moderate intensity aerobic training (3 sessions/week running for 60 min in each session at 40 to 60% of THR). Fasting blood samples were taken at two occasions between 8 to 9 am; baseline and after the intervention and the data were analyzed using paired samples t test and one way ANOVA at 95% significance level. 30% of the subjects had hypomagnesiumemia at baseline. Blood Mg was just elevated in the training-Mg group throughout the intervention (P<0.05). However; blood glucose, insulin, A1C, TG, waist circumference and blood pressure were all declined in both the training groups (P<0.05). Additionally, there were greater depressions in blood glucose and insulin levels of the training-Mg group rather than training placebo group (P<0.05). Aerobic training and synchronized Mg supplementation could provide a better diabetes control along with other therapeutic proceedings.