نشریه سوخت و ساز و فعالیت ورزشی
سال سیزدهم شماره 1 (بهار و تابستان 1402)

Aerobic training and Saffron has decreasing effects on apoptosis induced by exercise to exhaustion. The present study aims to investigate the Interactive effect of aerobic training with Saffron extract on BAX and Bcl2 proteins of cardiac tissue in trained rats following an aerobic exercise until exhaustion.

This is a clinical trial, 48 Wistar male rats were assigned into following four groups (N=12): control )C) , Saffron extract) SE) , Aerobic training (AT) , Aerobic training + Saffron extract (AT+SE). Aerobic training was done for five times a week for 8 weeks. Saffron extract was administrated through oral gavage 100 mg.kg-1.day-1. The end of experiment, half of the rats was killed immediately before exhaustive training; on the other hand, remaining rats were killed immediately after performing an acute bout of exhaustive exercise on the treadmill. BAX and Bcl2 proteins levels were measured by ELISA method. The data were analyzed using a one-way ANOVA, with the significance level of P < 0.05.

following an exhausting BAX and Bcl2 proteins of cardiac tissue in the all groups Except in the AT+SE group were significantly increased and decreased respectively (P < 0.05).

It seems that aerobic training and use of saffron extract Each one alone or in combination with each other prevented the significant change of Bax and Bcl2 proteins and BAX/Bcl-2 ratio following an exhausting exercise.

Galactin3 is known to be a novel inflammatory factor that increases with type 2 diabetes. Therefore, the aim of the present study was to investigate the effect of high intensity interval and moderate intensity continuous exercise on serum levels of Galectin3 in inactive obese men.

Eight obese men (mean age: 25.75±2.37 years and BMI: 31.96±3.03 kg/m2) performed protocols of high intensity interval exercise (HIIE), moderate intensity continuous exercise (MICE) and control (C) on separate days with a week. The HIIE protocol included six bouts of 1-minute running with intensity of 85% VO2max and 4 min active rest periods with intensity of 50% VO2max and the MICE protocol included 30 minutes running on treadmill with intensity of 65% VO2max which was matched with the HIIE protocol. Serum Galectin3 levels were measured by ELISA in 3 stages of before exercise, immediately after exercise, and 24 h after exercise.

Immediately after exercise, HIIE and MICE resulted in a significant increase in serum Galectin3 compared to the control group (p

Adipose tissue, as a metabolically active tissue, plays an important role in increasing inflammatory indices. So, the aim of this study was to investigate the effect of two-week high intensity interval training (HIIT) with thyme extract supplementation on some inflammatory and anthropometric markers in Tabriz city obese and overweight women. The current research was a semi-experimental study, and its statistical population consisted of overweight and obese women. To investigate CRP, ESR, TNF-α, quality of life, and body composition, 40 people were selected voluntarily with an average age of 33.07 ± 4.79, weight 76.76 ± 5.63, and body profile 29.02 ± 1.74, and were randomly divided into four homogenous groups (10 people in each group): training, supplement, training+supplement group and placebo. HIIT was performed for two weeks with 80-95% of HRR and Azarbaijani thyme was used as a supplement in two times a day. The data was analyzed using analysis of covariance test in the significance level of 0.05. The results showed that there is a significant difference in CRP (F=15, P=0.0001), TNF-α (F=25.56, P=0.0001), ESR (F=47.7, P=0.0001) , BMI (F = 20.71, P = 0.01) and WHR (F = 10.16, P = 0.01) between groups.. But there was no significant difference in calf circumference (F = 0.56, P = 0.64). Short-term HIIT alone or in combination with thyme reduces inflammation (CRP, ESR and TNF-α) and improve some anthropometric indicies in obese and overweight women.

The exercise training and vegetarian diets have been accepted as a suitable and non-pharmacological method to improve lifestyle and reduce metabolic diseases, including diabetes and metabolic syndrome. The aim of this study was to investigate the combined effect of aerobic exercise and vegetarian diet on insulin resistance factors.

The PubMed, Web of Science, SID, Magiran, and Google scholar databases were searched until February 2022 for English articles. Meta-analyses were performed to compare the impact of aerobic exercise and vegetarian diet on insulin resistance factors (fasting glucose, insulin, and HOMA-IR). Standardized mean differences (SMD), weighted mean differences (WMD), and 95% confidence interval (CI) were calculated using random and fixed effect models. Also, the I2 test was used to determine heterogeneity, and the Funnel plot and Egger tests at a significant level of 0.1 were used to determine publication bias.

The results of meta-analysis of 29 studies with 10019 adults, showed that aerobic exercise and vegetarian diet significantly decreased in body weight [WMD=-4.49, (CI: -6.27 to -2.72), p=0.001], fasting serum glucose [SMD=-0.46, (CI: -0.65 to -0.27), p=0.001], serum insulin [SMD=-0.42, (CI: -0.52 to -0.32), p=0.001], and HOMA-IR [WMD=-0.73, (CI: -0.97 to -0.49), p=0.001].

The findings of the present meta-analysis show the important role of exercise and vegetarian diet in improving insulin resistance. So, aerobic exercise and vegetarian diet are suggested as a non-drug approach for reducing fasting insulin and glucose for adults.

The aim of this study was to determine the Effects of aerobic training and High Fat Diet on the Gene Expression of Bax and Bcl-2 in the myocardium of adolescent male rats.

forty young male rats (30 days old) randomized in normal diet control (NDC), normal diet training (NDT), high fat diet control (HFDC) and high fat diet training (HFDT) groups. HFD rats followed high fat regimen (5.817 kcal/g) for 30 days and the normal fat diet (3.801 kcal/g) was continued following to the 60th day of birth. Aerobic training was conducted for four weeks included on three training sessions from the 70th to 98th days of life.

Our findings showed that in HFD groups the expression of Bax protein (from the apoptotic susceptible protein family) was increased and exercise was quite effective in preventing this increase. Instead, the high-fat diet caused a (but brief and insignificant) decrease in the expression of the BCL2 protein (from the family of anti-apoptotic proteins), although the effect of exercise and high-fat diet was not significant. Also, High fat diet increased the ratio of Bax protein expression to BCL2 protein expression (as an index of overall outcome reflecting , while training was well able to prevent this increase.

Overall, based on the results of this study, we conclude that consumption of high fat diet may also induce cardiac apoptosis even in adolescence and in addition to good physical activity in neutralizing these adverse effects of high fat diet is helpful.

Alzheimer's is a destructive brain disease that causes progressive cognitive disorders for which there is no cure. The aim of the present study was to investigate the effect of aerobic exercise along with the consumption of saffron extract on spatial memory and the amount of tau protein accumulation in the hippocampal tissue of Alzheimer's induced male rats. In this experimental study, 32 adult male rats were randomly divided into 4 Alzheimer's groups including control, aerobic exercise, aerobic exercise, extract and extract. Aerobic exercises including 3 training sessions per week were performed for 8 weeks. Y maze test was used to check spatial memory and ELISA method was used to measure tau protein. One-way analysis of variance was used to analyze the data. The results showed that after 8 weeks of aerobic training with saffron supplement, there was a significant increase in spatial memory performance in the intervention groups compared to the control group (P < 0.5). Also, regarding the amount of tau protein accumulation in the aerobic exercise group, aerobic exercise and extract showed a significant decrease compared to the control group (P < 0.5). It seems that aerobic exercise and consumption of saffron extract improves spatial memory performance and reduces the accumulation of tau protein in the hippocampal tissue of Alzheimer's male rats.

Performing sports activities along with the consumption of herbal supplements, especially in people, have different effects on the body's antioxidant and oxidant systems. The purpose of this research was to investigate the effect of eight weeks of intense interval training with chlorella supplementation on serum levels of malondialdehyde and total antioxidant capacity in obese or overweight middle-aged women. The statistical population of the present study consisted of overweight or obese middle-aged women (BMI ≤ 25) with an age range of 40 to 65 years. A number of 40 subjects were selected by invitation and based on the study entry criteria and randomly divided into four groups: exercise and supplement (10 people), exercise and placebo (10 people), supplement (10 people) and control (10 people). became HIIT exercises consisted of periods of 60 seconds of maximum intensity running (85-95% of the reserve heart rate) followed by 60 seconds of low-intensity running (55-60% of the reserve heart rate). The subjects did 6 times in the first week, 8 times in the second week. they completed the third to fifth weeks 10 times and the sixth to eighth weeks with 12 repetitions. Shapiro-Wilk test for normality of data and correlated t-test, one-way analysis of variance and Tukey's post hoc test to test hypotheses was used and the significant level was considered at the alpha level of 5%.

Obesity is one of the most serious health problems associated with inflammation. Physical activity is one of the many factors that affect obesity and inflammation. The aim of the present study was to evaluate the effect of six weeks of resistance training and high intensity functional training cross-fit on serum vaspin levels in obese women. The research method was quasi-experimental with pre-test-post-test design. Thirty six obese women of Semnan (age: 32.66 ± 3.91, weight: 86.97± 9.08 and BMI> 30) were selected as available and divided into three groups of high intensity functional resistance training (HIIF), Circular resistance training and control group (n = 12). The total training period consisted of 6 weeks and 3 sessions per week and each session was about 60 minutes. Serum levels of vaspin were avaluated befor and after the last training session. Serum vaspin levels did not change significantly in the circular resistance training group (P=0.876) and Crossfit training group (P=0.837). But the body mass index was significantly decreased in the circular resistance training group (P=0.001) and the Crossfit training group (P=0.006). Circuit resistance training and Crossfit reduce the body mass of obese women, but they do not have a significant effect on the serum level of vaspin. It is suggested to use circular resistance exercises and HIFT with a longer duration for a better effect.

Dietary supplementation with inorganic nitrate (NO3‒) may enhance exercise performance by improving skeletal muscle contractility and metabolism. CrossFit also, is recognized as a new method improves exercise performance but the interaction effects of nitrate supplements and CrossFitt on exercise performance are not well known. The present study was done to examine the interaction effects CrossFit training and beetroot juice on exercise performances in middle age inactive men. In this quasi study, twenty inactive men (aged 21-30 years old), were randomly divided into beetroot juice + CrossFitt group (n = 10) or placebo + CrossFitt group (n = 10). All participants were performed CrossFit training 3 days a week for 8 weeks. At the end week of the intervention, supplement group received 140 mL beetroot juice containing about 800 mg of NO3‒ per day. Exercise performances were evaluated before and after the intervention. The results demonstrated that sprint, anaerobic power and vertical jump test were improved in the both groups (P<0.05), however no significant differences were observed between two groups. Peak aerobic power was increased in the both groups (P<0.05), while the increase of peak aerobic power was higher in the supplement group compare to the placebo group (P<0.05). Generally, we can conclude that CrossFit training caused improves exercise performance but the interaction of beetroot juice and CrossFit cannot enhance these performances.

Diabetes is the most common endocrine disease in the world, and various methods such as exercise and physical activity are used to treat it. the aim of this study was to determine the effect of high-intensity interval training on serum glucose, insulin ,irisin and its gene expression in subcutaneous adipose tissue in type 2 diabetic rats. For this study, 20 males of the wistar male rat (8-10 weeks with a weight of 250-270 g) were selected and randomly divided into two groups of diabetic control and diabetic exercise. After the introductory course, the experimental group performed high-intensity exercise for 4 weeks, 5 days a week for 10 minutes as 1-minute interval at a speed of 30-40 meters per second. 48 hours after the last training session and after 12 hours of fasting, glucose and insulin values serum values and expression of irisin gene were measured in subcutaneous adipose tissue. Data were analyzed using independent t-test. The results showed that 4 weeks of high-intensity interval training reduced serum glucose levels and insulin resistance index (p = 0.001), significantly increased serum values (p = 0.001) and expressed irisin gene (P = 0.004) in subcutaneous adipose tissue was controlled in the exercise group compared to the group.High-intensity interval training can reduce serum glucose levels and insulin resistance index in type 2 diabetic rats and increase serum levels and irisin gene expression in adipose tissue. it is suggested to use this type of exercises to reduce the problems caused by type 2 diabetes.

The aim of the present study was to investigate the effect of two types of intense training on the levels of thioredoxin reductase-1 enzyme and malondialdehyde in testicular tissue of male wistar rats.19 male Wistar rats,8weeks old and weighing200± 5g, after10 sessions of introducing training protocols and after weighing, were randomly divided into3groups(control, intense endurance training, intense training).Intense endurance training protocol included running on a treadmill for8 weeks and intense periodic training protocol included running on a rodent treadmill for 8 weeks. 48 hours after the last training session,the rats were anesthetized with ether and sacrificed and then the testicular tissue was isolated under sterile conditions.The amount of Thioredoxin Reductase-1 was determined by ELISA method and using a spectrophotometer and also the concentration of Malondialdehyde was determined by three Barbituric acid method using a spectrometer. One-way ANOVA with Tukey's post hoc test was used to analyze the data.After8 weeks, the amount of Enzyme in the intense endurance training group and intense periodic training group increased significantly compared to the control group(P<0.05). Also,there was no significant change in the amount of Malondialdehyde in testicular tissue of the intense endurance training group and intense periodic training group compared to the control group(P>0.05). According to the results of this research,it can be said that intense endurance training and intense periodic training has increased the amount of thioredoxin reductase-1 enzyme in a testicular tissue and by creating adaptation in the body's antioxidant system, has not increased malondialdehyde.

One of the new training methods to increase the performance of athletes is ischemic preconditioning (IPC). the aim of the present study was the effect of ischemic preconditioning and beetroot supplementation on anaerobic performance of male cyclists.

12 male cyclists participated in a randomized study with a crossover design. The tests of maximum power output and one kilometer cycling time trial were evaluated in the same laboratory conditions. All subjects consumed 60 grams of beetroot supplement and placebo for one week. There was a 7-day washout period between the two supplement and placebo periods.maximum power output and one kilometer time trial tests were performed along with the ischemic preconditioning method. Ischemic preconditioning for all subjects, including 4 periods of 5 minutes of occlusion and reperfusion using a cuff with a width of 15 cm and a pressure of 220 mmHg applied to the uppermost part of the legs. Shapiro-wilk test and repeated measurement were used to check the data.

Ischemic preconditioning significantly increased maximum power compared to control (P=0.027). Although after taking red beet supplement and ischemic preconditioning, the maximum power output was higher than the control condition, but no statistically difference was observed (P=0.09). The time trial of one kilometer after ischemic preconditioning (P=0.014) and also after consumption of beetroot supplement along with ischemic preconditioning was significantly lower than the control condition (P=0.008).

ischemic preconditioning and beetroot supplementation can improve anaerobic performance in adult male cyclists