The effect of combined training and vitamin D supplement consumption on some indicators of muscle damage, inflammation and antioxidants in addicted women

Aim of this study was to determine effect of 8 weeks combined training and vitamin D consumption on some of muscle damage, inflammatory, and anti-oxidative indices in drug addicted women.

In a semi-experimental study design, 32 addicted women to methamphetamine and heroin, with average age of 28.3 ± 6.7 years, weight of 62.06 ± 10.3 kg, and BMI of 24.10 ± 2.9, were chosen from an addiction treatment camp and randomly divided into four groups of training, training + supplement (vitamin D), supplement, and control. Training group did resistance training with intensity of 40–70% of one-repetition maximum for 18 to 28 min and aerobic training with intensity of 50–70% of heart rate reserve for 12 to 37.5 min for 8 weeks with 3 sessions in each week. In order to measure muscle damage, inflammatory, and anti-oxidative enzymes blood samples were taken before and after training protocol and supplementation. To check normal distribution of data, Shapiro-Wilk test was used. For analyzing the effect of independent variables, one-way ANOVA with repeated measures, dependent T test, and post-hoc Bonferroni test at significance level of 0.05 were used.

Results of dependent T test showed that creatine kinase in training and training + supplement groups, Lactate dehydrogenase in training group, and total antioxidant capacity in training + supplement group were significantly increased (p < 0.05). Malondialdehyde in training + supplement and supplement groups, and C reactive protein in training + supplement group showed significant decrease (p < 0.05). Between groups comparison showed that compared to control group, total antioxidant capacity indices and C reactive protein in training + supplement group were significantly increased and decreased, respectively (p < 0.05). In addition, creatine kinase in both training + supplement and training groups, was significantly increased compared to control group (p < 0.05).

Vitamin D supplementation with combined training can increase total antioxidant capacity and decrease C reactive protein in drug addicted women.