Effect of Aqueous Extract of the Coriandrum Sativum Seed on the Reduction of Acute and Chronic Pain in Mice

Previous investigations have shown that Coriandrum Sativum (CS) extract probably modulates pain in human and animal. The aim of this investigation was assessment of the role of CS on acute and chronic pain by formalin test in mice. In this study, 35 male albino mice in 5 groups (25-30g) were used. CS extract (100, and 200mg/kg), or saline were injected intera-peritoneal (IP) 30 mins before the formalin test. Indices of signs of pain were licking and foot elevation for assessment of acute pain (5 min), and chronic pain (15-40 min) after the injection of formalin 5% (25µl) in the right paw. Reasults: Results showed that although CS extract has analgesic effect in both doses in acute and chronic pain, (p<0.01) but higher doses is more effective, where as 100mg/kg reduced the acute and chronic pain 0.82 but for 200mg/kg it was 0.91. Findings of this study indicated that CS extract can modulate acute and chronic pain induced by formalin injection. Further research is required to determine the mechanisms by which CS has an inhibitory effect on pain sensation.