Effect of 8 weeks resistance training on glomerular filtration rate and CD5 antigen-like of male patients with type 2 diabetes

Exercise is recommended for the management of type 2 diabetes, but its effects on renal function in patients with type 2 diabetes are not well known. The aim of present study was to examine the effect of 8 weeks resistance training on glomerular filtration rate (eGFR) and CD5 antigen-like (CD5L) of male patients with type 2 diabetes. Twenty-two men (age: 51.5 ± 3.3 years and body mass index: 27.1 ± 3.2 kg/m2 mean ± SD) with type 2 diabetes participated as the subject. The subjects were randomly assigned to control or training group based on their eGFR. The subjects in the training group performed 3 sets with 8 to 15 repetitions of resistance training with 50-80% 1RM, 3 days a week for 8 weeks. The subjects in the control group were instructed to maintain their normal physical activity throughout the study. Fasting blood sugar, fasting insulin, insulin resistance, eGFR and CD5L were measured at baseline and 48h after the intervention. The results indicated that fasting blood sugar, insulin resistance index and CD5L decrease in the training group compare to the control group (P<0.05); however, fasting insulin has no significant change after the intervention. Although eGFR has no significant change in the training group; but it was decreased significantly in the control group (P<0.05). In summary, it seems that resistance training utilized in this study improves blood glycemic and renal function in patients with type 2 diabetes.