Studying the possible effects of short-term and long-term ketamine anesthesia on the histopathological changes of the cerebral cortex

Ketamine is one of the most common drugs that weaken the central nervous system and alertness, and it is essential to know its side effects.

The purpose of this study is to investigate the effects of short-term and long-term anesthesia of ketamine on the histopathological changes of the cerebral cortex in rat infants.

This study was conducted on 15 female rats (3 groups of 5 including the control group, the long-term anesthesia group with ketamine, and the short-term and repeated anesthesia group (with ketamine). Then the histopathological changes of the cerebral cortex were analyzed by IHC immunohistochemistry method. SPSS software was used to compare the data.

The findings of our study showed that no changes were observed in the brain tissue and different layers in the samples of the control group, and the order and coherence of the brain tissue was reported to be completely clear and normal. There is no significant change in the short-term and long-term dose groups of ketamine, compared to the control group, and only the number of microglia cells was lower than the control group.

Ketamine reduces the number of microglia cells both in the short term and in the long term, and investigating the cause requires biochemical studies, free radicals and other effective factors that play a role in cell apoptosis. Although memory and learning were not examined in our study, the findings of our study did not show drastic changes in the tissue. However, a more detailed examination of the changes in the biochemical and behavioral changes of the mice needs a more detailed examination in subsequent studies to address all aspects of the effect of ketamine on the brain.