Relationship between the Dose of Erythropoietin and the Dialysis Adequecy

The aim of the present study was to examine the relationship between the dose of recombinant human erythropoietin (EPO) and the dialysis efficacy in shahroud hemodialysis patients. After the inclusion of subjects with atleast 6 months history of dialysis, therapy requirements of subcutaneus EPO for 4 months, frettin>100 ng/ml and target hematocrite to 30%, data from 54 hemodialysis patients in shahroud were collected. Dialysis adequecy was evaluated with Kt/V index. Thirty males (55.6%) and 24 females (44.4%) were evaluated that in 38 patients (70.4%) equilibrated Kt/V was less than 1.2 (low adequecy) and 29.6% (16 patients) have equilibrated Kt/V over 1.2. Frettin, iron, Hb and HCT levels did not differ between the 2 groups, but in patients with Kt/V>1.2 the mean injected EPO dose was significantly less than the other group. Compared with other study we identified that adequate dialysis (Kt/V>1.2) can reduces the need to EPO doses and also can to decrease its costs and side effects.