RELATIONSHIP BETWEEN RESPIRATORY DISTRESS SYNDROME SEVERITY AND CIRCULATING PLATELETES AND LEUKOCYTES IN THE 5 FIRST DAYS OF LIFE IN PRETERM INFANTS

Respiratory distress syndrome is the most common cause of hospitalization in newborn that is mainly appears in the preterm infants and had revers ratio with gestational age and weight. The main cause of this disease is the surfactant dificiency that is lead to increased the alveolar surface tentionand it causes atelectasis. The cause of extent incidence of pulmonay hemorrage and infection in pathological speciamen maybe release of chemical mediators from polymorphonucloar leukocytes (PMNS) and platelets and this can cause decreased of these circulating cells. Thus, there is relationship between severity of respiratory distress syndrome (RDS) and circulating leucocytes and plateletes. The goal, of this cross-sectional study was determine of association between severity of RDS and circulation leukocyte and platelets in the first 5 day of life. For this reason, newborn that hospitalized with respiratory distress syndrome in NICU in akbarabadi hospital in 1998, have been choosen. Newborn with premature rupture of membrane, sepsis, intrauterine growth retardation, meconium aspiration or neonates that theire mothers who recived dexamethazone were omitted for effects of this agent on the circulating PMN and platlets. Thus, 66 preterm infants have been choosen and according to need to mechanical ventilation were divided to sever and mild to moderate groups. 29 infants were in sever group (43.93%) and 37 infants in mild to moderate group (56.06%). The average of the circulating platelets in first 5 days of life, in sever group was 108051.7 and in mild to moderate group was 223527, that according to statistic test. T=0.7222 and Pvalue<0.00001 that is revealed meanfull difference between two groups. The average of the leucocytes (PMNs) in first 5 days of life in sever group was between 2695.21 and 1130.13 and in mild to moderate group was between 5324.59 and 1507.72. The result of the statestic test was T=7.84289 and Pvalue<0.000001 that revealed meanful diffence in two groups. There is assosiation between severity of respiratory distress syndrome in infants and circulatory PMN and platelets.