Atherosclerosis and Statins

According to inconsistencies in the various studies about effect of statins on atherosclerosis and issue importance, the aim of the present research was review carried out in statins and atherosclerosis. By the use of atherosclerosis, statins and hyperlipidemia as keywords, we searched in PubMed through 1980 until 2011. Most studies showed the reduction of total cholesterol and Low density lipoprotein (LDL) by Statins, but there showed a little effect on increasing High density lipoprotein (HDL). In most studies mechanisms of action of statins were stabilization atherosclerotic plaques consequently inhibit oxidation, improve endothelial function by increase Nitric oxide and improvement thrombotic state by inhibiting platelet. Most Of Clinical trials had shown positive effect of statin on cardiovascular disease and atherosclerosis. Therefore, using of them for treatment of hyperlipidemia could be appropriate preventive for atherosclerosis and cardiovascular accidents. Although the exact mechanism of action is not clear, there is a need for further investigation.