International journal of basic science in medicine
Volume:8 Issue: 2, Jun 2023

Many patients with COVID-19 complain about the remaining symptoms after being discharged from the hospital. Therefore, monitoring possible complications after contracting COVID-19 can play a significant role in the management of this disease. The purpose of this study was to assess long-term complications in patients with COVID-19.

Patients with COVID-19 who were referred to the hospital from June to November 2021 were examined in our cross-sectional study. Before the discharge of patients, the six-minute walk was performed and the patient’s clinical information was recorded. Then, patients were recalled and analyzed 2 weeks and 1 month after discharge.

Ninety-one patients participated in our study. After 2 weeks, fatigue with a prevalence of 62.6% was the most common clinical symptom residual in patients. In addition, 1 month after discharge, dyspnea (46.4%) and fatigue (35.7%), as well as muscle weakness and anxiety (28.6%), were the most common symptoms. The mean of oxygen saturation was 93.43±3.71 two weeks after discharge and 94.79±2.14 one month after discharge. The distance traveled at 6-minute walk test (6-MWT) was not significantly increased 1 month after discharge (P=0.43). However, the mean of forced expiratory volume in 1 second (P=0.001), forced vital capacity (FVC) average (P=0.002), and total lung capacity (TLC) (P=05) increased significantly after 1 month.

According to the results of this study, in some patients with COVID-19, symptoms such as dyspnea and fatigue remain until 1 month after discharge from the hospital. In such patients, chest computed tomography scans, pulmonary rehabilitation, and patient follow-up can help patients recover faster.

 Cancer can affect the process of recovery and the quality of life (QoL) of individuals. This study determined the effectiveness of combined couple therapy based on acceptance and commitment and schema therapy on the QoL and recovery process of patients with breast cancer (BC) during medical treatment.

 The research method is semi-experimental with pre-test, post-test, follow-up, and control group. The study’s statistical population included all married patients with BC (stage one) who received treatment in Mashhad in 2019. A total of 30 samples were selected through the convenience sampling method and then randomly assigned to the control and treatment groups. The exceptional EORTC QoL questionnaire (QLQ-C30) was used in patients with cancer to collect data, and the recovery symptoms were checked according to medical records and the relevant specialist’s opinion. The data were also analyzed by repeated measures analysis of variance to analyze the obtained data.

 The findings demonstrated that the combined couple therapy based on Acceptance and commitment therapy (ACT) had a significant effect on the QoL and recovery process of patients with cancer during medical treatment (P>0.01).

 The results imply that couple schema therapy-based ACT could positively affect the QoL and treatment processes among cancer patients.

The epidemic caused by the spread of the infectious agent called severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has posed a huge challenge to various communities around the world. The high prevalence and widespread infectivity of this virus indicated that despite the relentless efforts of various biological scientists to provide appropriate treatment or control of the disease, no definitive treatment has been reported successfully. Since the source of infection of this virus is an entry into the host cell through the specific angiotensin-converting enzyme-2 (ACE2) receptor, in the present study, we reviewed the ACE2 receptor and its role in SARS-COV-2 infection.

Adiantum capillus-veneris L. (Pare-siavashan) is a plant from the Pteridaceae family with many uses in traditional and folk medicine. This plant grows in different parts of the world. According to the references of Persian medicine, it has many positive effects on the digestive system, urogenital system, integumentary system, eyes, spleen, edema, and respiratory system (e.g., dyspnea). It is used in folk medicine in parts of the world to cure menstrual disorders, cold, cough, abdominal pain, fever, headache, bronchitis, hair loss, and diabetes. Contemporary researchers have proven the antioxidant, antimicrobial, and anti-inflammatory effects of this plant. The clinical studies conducted on the effects of this plant on respiratory diseases are few and more research is necessary. According to the properties mentioned for this plant, its use in the treatment of asthma and inflammatory diseases of the respiratory tract and its infections can be considered.

Endothelial cells (ECs) that line the inner surface of blood vessels play a crucial role in maintaining healthy blood vessels and regulating consistent blood flow. EC dysfunction (ECD) is the improper functioning of ECs as a result of any modification or damage. Numerous health issues such as cardiovascular disease, hypertension, lightheadedness, exhaustion, diabetes, and the like could result from this. Both extrinsic and intrinsic factors may cause ECD. Many virus-induced hemorrhagic fevers, including dengue fever, Ebola, and Lassa fever, exhibit ECD. ECs maintain barrier functions by regulating immune cell interactions, homeostasis, and capillary permeability, and in viral infections, viral interaction alters these factors. These pathogens destroy ECs, leading to a loss of integrity in the blood vessels and increased permeability. Hemorrhagic fever can cause a wide range of symptoms such as fever, headache, muscle pain, weakness, exhaustion, bruises, bleeding, shock, and occasionally even the emergence of additional issues such as organ failure. Hemorrhagic fevers can be life-threatening if not treated promptly and correctly. Considering that ECD can be a silent condition, consultation with physicians about individuals’ risk factors and regular screenings to detect and prevent this condition is highly important. There is no specific antiviral treatment for most hemorrhagic fevers, but research is ongoing to develop effective treatments. This review will discuss the ECD due to viral interactions to cause hemorrhagic fevers, available treatments, and challenges associated with such viral hemorrhagic fevers (VHFs).