حسن نکیسا

Oxidative stresses are involved in neuronal degeneration of substantia nigra and thereby induction of Parkinson's disease. It is reported that Foeniculum Vulgare L. can affect lactating and modulating dopaminergic system activity and antioxidant activity as well. In the present study, the effects of methanolic extract of Foeniculum Vulgare seeds on a Parkinson’s disease model induced by ICV injection of 6-hydroxydopamin (6-OHDA) in female rats were investigated.

In this experimental study, 60 female rats were randomly divided into 6 equal groups including saline, Parkinson’s disease and Parkinson’s groups which were treated by different doses of the extract. Parkinson’s disease was induced by i.c.v injection of 6-OHDA. Methanolic extract of Foeniculum Vulgare seeds (100 and 200 mg/kg) was gavaged through two ways including repeated gavage (14 days before and 14 days after 6-OHDA injection) and acute gavage (once every day for 14 days after 6-OHDA injection). The induced Parkinson`s disease. was evaluated using Rotarod and Wire grasping tests on the day 14th after 6-OHDA injection.

The findings of the study demonstrated that repeated gavage of Foeniculum Vulgare extract improved motility and muscle tone in Parkinson’s animals (Pp<0.05). However, acute gavage of the extract had no significant effect on the performance of Parkinson’s animals.

Results of the current study showed that chronic administration of Feoniculum Vulgare extract may improve Parkinson’s symptoms in female rats.

Oxidative stresses have some role in neuronal pathogenesis in Substantia nigra and induction of Parkinson's disease. It has been reported that Achillea millefolium has antioxidant and nuoropropective effects. In this study, we investigated the effects of Aqueous extract of Achillea millefolium in a Parkinson’s diseases model induced by ICV injection of 6-hydroxydopamin in male rats. In this experimental study, 60 male rats were allocated into 6 groups including Control, Parkinson’s and Parkinson’s groups which treated by different doses of extract. Parkinson’s was induced by i.c.v injection of 6-OHDA. Aqueous extract of Achillea millefolium (1.4 and 2.8 mg/kg) was gavaged by two ways including repeated gavage (14 days before and for 14 days after 6-OHDA injection) and acute gavage (once in day 13 after 6-OHDA injection). Parkinson’s was evaluated using Rotarod and Wire grasping tests on day 14 after 6-OHDA injection. The result of this study demonstrated that repeated gavage of Achillea millefolium extract improved motility and muscle tone following administration of 6-OHDA in rats (p<0.05). The results of this study demonstrated that chronic administration of Achillea millefolium extract may improve motility and muscle tone in Parkinson’s model in male rats.