فهرست مطالب سروش شاه حسینی

telomere erosion is considered to be the main cause of aging. The present study aimed to determine the interactive effect of high-intense interval training and resveratrol consumption on telomere length and expression sirtuin 6 genes of hepatocytes in elderly rats.

25 Wistar male rats were divided into 5 groups. 1. Control group that did not exercise, 2. The solvent group that only received the solvent, 3. Exercise actively group that swam 20 seconds with 10 seconds rest in 6 weeks and 3 sessions per week, 4. Supplement group that received resveratrol 10 ml/kg per day, and 5. Combination of exercise and supplement goup that uses combination of exercise and supplement. Quantitative Real time PCR was used to measure the expression levels of sirtuin 6 gene and telomere length. For data analysis, One-way analysis of variance, and tukey tests were done usingSPSS 25 software.

Resveratrol consumption and exercise significantly increased telomere length compared to control in order (P=0.000, 0.001) and solvent (p=0.007, 0.004) groups, respectively. The expression of the sirtuin 6 gene was not affected by resveratrol (0.984), while exercise increased the expression of the sirtuin 6 gene (0.013). The combination of resveratrol supplementation and exercise did not double telomere length (0.395) and sirtuin 6 expression (0.502).

The interaction of very  high-intensity interval training and resveratrol supplementation does not double the expression of the sirtuin 6 gene and telomere length of old rat liver cells. The molecular mechanism for slowing telomere erosion is probably complex and unaffected by mentioned concurrent interventions.

Given that more than 50 percent of patellofemoral pain syndrome include of overuse injuries, the aim of this study was to compare the vastus medialis muscle activity in individuals with patellofemoral pain syndrome after a period of strength and flexibility training with and without the electrophysiological feedback. A total of 30 subjects (15 men and 15 women) participated in this study. Subjects were divided into three groupchr('39')s control, therapeutic and therapeutic with electrophysiological feedback. One-way ANOVA was used to compare the activity of vastus medialis muscle in between groups. The results of this study showed that there was a significant difference between the groups in the activity of the vastus medialis muscle activity (P <0.05). The results of Tukeychr('39')s post hoc test for intra-group comparisons showed that there was a significant difference between the control group with the therapeutic group (P = 0.024), the control group with the therapeutic group and the electrophysiological feedback (P=0.028) and the therapeutic group with the therapeutic group and the electrophysiological feedback (P<0.001).

Regarding the results of this study, therapeutic exercises with electrophysiological feedback have a greater effect on the activity of vastus medialis than the therapeutic group in patients with patellofemoral pain syndrome.