عادله ناصری

Introduction and Brain trauma is one of the most common causes of damage to the central nervous system that can cause death and long-term disabilities. The purpose of this research is to investigate the effect of a swimming training course on the amount of memory and interleukin-6 in the hippocampus and prefrontal cortex of rats with brain trauma. The current research is experimental and developmental. 40 NMRI male mice were randomly divided into 2 equal groups (trained mice and non-trained mice). Mice in the training group underwent swimming training from the age of 28 days to the age of 80 days for 8 weeks (5 days per week). After completing the exercise protocol, each group was divided into 2 equal groups by a simple random method, rats without training (control, trauma) and training rats (swimming training, swimming training trauma). At the end of the eighth week, trauma induction was performed on the right temporal region in the trauma swimming training group and trauma by weight drop method. 14 days after trauma induction, the rats were tested for new object recognition memory. Statistical analysis was done through one-way analysis of variance with Tukey's post hoc test at a significance level of P≥ 0.05 and using SPSS-26 software. The results of the research showed that 8 weeks of swimming exercise significantly increases the amount of memory in rats suffering from brain trauma (P=0.001). Also, 8 weeks of swimming exercise causes a significant decrease in the amount of interleukin-6 in the prefrontal cortex of rats with brain trauma (P=0.003), but this decrease was not significant in the hippocampus (P=0.076).Discussion and The results of the present study showed that swimming exercises before brain trauma can reduce inflammation and memory disorders caused by brain trauma through mechanisms such as reducing the level of pro-inflammatory cytokines such as interleukin-6.

Brain trauma is one of the most common causes of damage to the central nervous system which can lead to death and long-term disability. The present study aimed at investigating the effect of 8 weeks of swimming exercise on the level of memory and interleukin 10 (IL-10) in the hippocampus and prefrontal cortex of mice with brain trauma.

40 male NMRI mice were randomly divided into four groups (control, swimming, trauma, swimming + trauma). After completing the exercise protocol, induction of trauma was performed by the weight -drop method. Ten days after trauma induction, the mice were evaluated for spatial memory with Y-maze test. The IL- 10 level was measured using ELISA technique. One-way analysis of variance and Tukey post hoc test were used for statistical analysis at a significance level of p<0.05 and using SPSS software version 26.

The study results indicated that eight weeks of swimming exercise significantly increase memory in mice with brain trauma (p=0.001). Furthermore, eight weeks of swimming exercise significantly increase the level of IL-10 in the hippocampus of mice with brain trauma (p=0.001). However, this increase was not significant in the prefrontal cortex (p=0.126).

The results of the present study showed that swimming exercise before induction of brain trauma reduces inflammation and memory disorders and facilitates recovery after injury. Previous exercise training can probably reduce inflammation by increasing the amount of anti-inflammatory cytokines, including interleukin-10, and limit secondary damage with its protective effect.