فهرست مطالب مجید مقیسه

Today, cancer is known as one of the biggest public health problems and the second cause of death in the world, and due to its high prevalence, it is considered as one of the main health problems all over the world. There are many treatment strategies, including chemotherapy, to treat cancer in patients. Chemotherapy is actually the use of antineoplastic drugs alone or in combination with other drugs. Of course, these drugs can also damage the function of healthy cells and cause many side effects. Anthracyclines are one of the most widely class of drugs used in cancer chemotherapy, doxorubicin, daunorubicin, and epirubicin are among the anthracycline drug group, the most widely used of which is doxorubicin, which causes cardiotoxicity in the patients undergoing chemotherapy, and unfortunately, there is no definite and reliable treatment for it. Various strategies have been used to reduce the toxic effects of doxorubicin on non-target tissues, including the use of medicinal plants, diet and various types of long-term exercises with the aim of increasing tissue antioxidant levels. Therefore, determining the appropriate exercise and nutrition program considering the physical conditions for cancer patients who are undergoing chemotherapy treatment is so important. Therefore, the current review study aimed to determine the effects of DOX cytotoxicity on heart tissue and the benefits of regular physical activity and curcumin supplementation were investigated and discussed.

The use of curcumin with aerobic exercise is likely to be a potentially useful candidate to protect against the toxicity of blood cells caused by the drug doxorubicin, which is used to prevent the growth and progression of cancer cells in patients

Doxorubicin is a universal drug in the treatment of all types of cancers, which is limited due to its many side effects. Therefore, the present study has investigated the effect of aerobic exercise and the use of curcumin nano micelles on the activity levels of BAX, BCL2, and MDA concentration in doxorubicin-induced cardiotoxicity in mice with breast cancer.

In this research, which was of a fundamental type and controlled experimentally, 24BalbC female rats were randomly divided into 4 groups: doxorubicin, doxorubicin patient and exercise, doxorubicin patient and nano curcumin supplement and doxorubicin patient, exercise and supplement. Breast cancer induction was done with MC4-L2 cells. Doxorubicin 2mg/kg was injected subcutaneously 6 times on day 28, 21, 14, 7, 1 and 35. The aerobic program consisted of 5 sessions per week for 42 days with an increase in the speed of the treadmill every two weeks including 14, 16, and 18 meters per minute and the use of nano curcumin at a dose of 100mg/k. The collected data were analyzed with a two-way analysis of variance with a significance level of 0.05 in the tests.

6 weeks of aerobic training had no effect on BCL2 activity and MDA concentration, but it significantly decreased BAX activity. Taking nano curcumin supplement for 6 weeks decreased BAX activity and MDA concentration and significantly increased BCL2 activity. Conclusion 6 A week of aerobic training along with nano curcumin supplementation did not affect BAX activity and MDA concentration, but it caused an increase in BCL2 activity (p value < 0.05).

Aerobic exercise and the use of curcumin nano micelle supplement separately or at the same time can be effective in reducing the cardiac toxicity of doxorubicin in patients with breast cancer.

Doxorubicin is a pervasive drug in cancer treatment, but its consumption is restricted due to various side effects in the body tissues. Therefore, this research aimed to reduce the side effects of this drug through the impact of a period of aerobic training along with the consumption of curcumin nano micelles on the expression level of CAS3, CAS9, BCL2, and BAX genes in cardiac tissues of Balb C mice with breast cancer induced by 4T1 cell line.

24 female Balb/C mice were randomly assigned to four control groups:  treated with doxorubicin, treated with doxorubicin and aerobic exercise training, treated with doxorubicin and nanocurcumin and bimardoxorubicin supplement, aerobic exercise training, and supplement. The 4T1 cell line, arising mouse mammary tumor, was used in this study. Doxorubicin (2mg/kg) was injected subcutaneously six times on days 28, 21, 14, 7, 1, and 35.

Aerobic exercise training significantly decreased the expression level of CAS3, CAS9 and BAX genes, while it had no significant effect on the level of BCL2 (P≤ 0/05). Nanomicelle curcumin supplement caused a significant decrease in the expression of CAS3 and CAS9 genes, but it had no significant effect on the BAX gene expression. However, it caused a significant increase in BCL2 gene expression (P≤ 0/05).

It can be concluded that aerobic exercise training and consumption of Nano micelles containing curcumin as a therapeutic supplement alone or simultaneously reduced sensitivity to cardiac apoptosis and protected non-target tissues in the heart during doxorubicin therapy. Doxorubicin (DOX) inhibits the growth of tumor cells and improves the effectiveness of cancer treatment.

Doxorubicin is a universal drug in treatment of all types of cancers, which is limited in its use due to various side effects in body tissues, so the present study investigated effect of aerobic exercise and use of curcumin nanomicelles on gene expression of the enzymes (GlutathionePeroxidase) GPX, (Catalase) Cat (Superoxidedismutase) SOD and (Malondialdehyde) MDA was investigated in the heart tissue of BalbC female rats with induced breast cancer in the treatment phase of doxorubicin.

This research was practical, it was experimental in terms of control of variables and it was a laboratory in terms of place of implementation. Thirty-six BalbC mice were randomly divided into 6 groups (n=6): healthy, patient, doxorubicin patient, doxorubicin patient and aerobic exercise, doxorubicin patient and nanocurcumin supplement, and doxorubicin patient, aerobic exercise and supplementation. Breast cancer induction was done with MC4-L2 cells. Doxorubicin 2mg/kg was injected subcutaneously 6 times on days 1,7,14,21,28 and 35. Aerobic program consisted of 5 sessions per week for 42 days with an increase in the speed of the treadmill every two weeks, including 14, 16 and 18meters per minute and the use of nanocurcumin at a dose of 100mg/kg.The data collected with SPSS version16 and two-way analysis of variance and for the normality of the frequency distribution with skewness and non-parametric Kolmogorov-Smirnov test were performed with a significance level of P ≤ 0.05.

Six weeks of aerobic training had no effect on the expression of GPX, MDA and SOD genes in the target groups, but it significantly increased the expression of Catgene (P ≤ 0.05). The use of nanocurcurmin supplement for 6 weeks decreased the expression of MDA gene and significantly increased the expression of GPX, SOD and Catgenes. Six weeks of aerobic training along with nanocorcurmin supplementation significantly increased Cat gene expression (P≤0.05), but had no effect on GPX, MDA and SOD gene expression.

Aerobic exercises and the use of nanocurcurmin supplement separately or at the same time can be effective in reducing the cardiac toxicity of doxorubicin in the patients with breast cancer.