فهرست مطالب محسن مسجدی

Patients with vitiligo often have aesthetic, cognitive, and psychological challenges that create adverse social and psychological effects for these patients. The purpose of this study was comparing effectiveness of “Schema Therapy" and “Mindfulness- Based Cognitive Therapy” on maladaptive schemas and general health in patients with Vitiligo. The present study was a semi-experimental pre-test and post-test design. The statistical population included all patients with vitiligo disorder referring to the skin clinic of AL Zahra Hospital in Isfahan. 24 patients were selected by convenience sampling method. Subjects were then randomly assigned into three groups: “Schema Therapy" and “Mindfulness- Based Cognitive Therapy” and control. For intervention, the patients undergoing “Mindfulness- Based Cognitive Therapy” group training were trained for 9 sessions and 8 weeks for the intervention of the patients in the "Schema Therapy" group. Data was collected by “General Health Questionnaire" and the “Young's Schema Questionnaire-Short Form”. Then the validity and reliability were measured. Data was analyzed by SPSS 21. The results of covariance analysis showed that there is a difference between maladaptive schemas and general health between the “Schema-therapy” and “Mindfulness- Based Cognitive Therapy” and control group. Comparison of the results showed that scores differences between schema therapy group and control group were significant. In addition, there was a significant difference between the scores of “Mindfulness- Based Cognitive Therapy” and control group (P≤0.05). However, there was no significant difference between the two groups of “SchemaTherapy” and “Mindfulness- Based Cognitive Therapy”. SchemaTherapy, “Mindfulness- Based Cognitive Therapy” is considered as two effective therapies for reducing maladaptive schemas and promoting health of patients with vitiligo. Therefore, therapists and practitioners can use the results of this research to reduce internal conflicts and inefficient schemas of their skin patients.

This study aimed to evaluate the effects of spirituality on the lifestyle and the percentages of the white blood cells in the depressed aged subjects. A quasi-experimental method with pre-test and post-test was used. Statistical society of research consisted of the total depressed aged subjects of an aged house (Mehr aged house, Karaj city, Alborze province, Iran).The subjects were divided into two equal groups (12 experimental group and 12 control group) and they responded the lifestyle questionnaire. Then, the percentages of the white blood cells were measured using the flowcytometry method. The experimental group received 14 sessions of the spiritual intervention, then lifestyle and the percentages of the white blood cells were measured. The results showed that there was a significant difference between the experimental and control groups after the intervention on the lifestyle (health, disease prevention, mental health, spiritual health and social health) and the percentages of the white blood cells (neutrophils, lymphocytes, monocytes) (P≤0.05).Thus, spirituality, as a protective factor can promote the health of aged subjects, due to improvement of lifestyle and higher percentages of the white blood cells.

An elevation in the mean percentages of the gamma delta T lymphocytes per total T cells in the epithelium of the small intestine has a diagnostic value for celiac disease. This study aimed to measure the percentages of the peripheral blood gamma delta T lymphocytes in the adults'' celiac disease and healthy controls.

In this case-control study the absolute numbers of the peripheral blood lymphocytes obtained from the controls (n = 21) and celiac patients (n = 15) were studied، Using a cell counter. The proportions of the gamma-delta T lymphocytes were evaluated by the flow cytometer method.

The results showed that there was not significant I difference in the percentages of the gamma-delta T lymphocytes between celiac patients and healthy individuals (P value= 0. 84).

Collectively، the data show that the percentages of the peripheral blood gamma delta T lymphocytes could not be helpful for celiac disease diagnosis.

Human growth hormone (hGH) is a secretory protein of the blood which is used extensively in biotechnology and medical sciences. Recombinant human growth hormone production is still one of the priorities of the Iranian Ministry of Health. One of the most sensitive and accurate techniques for the measurement of this hormone is the ELISA method. Scientists need to produce antibody against hGH to measure the serum level of hGH in patients. Commercial ELISA kits are commonly imported from other countries to Iran. Therefore، the current study aimed to produce a polyclonal antibody against hGH in order to make a domestic ELISA kit to measure this hormone. Rabbit polyclonal antibody against hGH was produced following 10 weeks of immunization by the antigen injection. The antibody characteristics were evaluated by immunoblotting. The purified antibody was used to design the ELISA kit. The designed sandwich ELISA method was standardized concerning the amount of antibody coating and antibody conjugate. Ultimately، the sensitivity and specificity of the designed kit was compared with the foreign kits. The polyclonal antibody against hGH was produced in rabbits and purified successfully. This antibody can be used in the western blot and ELISA methods. The diagnostic value of the designed kit was 98%، compared with the foreign kits. This kit has a diagnostic value in the assessment of hGH; therefore، it can be a good alternative to the commercial kits. Therefore، this antibody and ELISA kit can be produced more cost-effectively and can be a step towards self-sufficiency.

Employees in night shift experience sleep deprivation continuously. Stress-induced insomnia affects on fatigue and reduces maximum activity. During the shifts، hormonal changes affect on immunoglobulin M (IgM) operation. Individual differences in encounterring and adaptation with shift-induced stress can be effective to determine vulnerability. The aim of this research was to assess the relationship of personality traits، chronic fatigue and serum IgM level in patients with sleep deprivation. The study population was the shift employees in steel factories in Isfahan، Iran. A total number of 221 male employees were selected with random cluster sampling. Personality traits، (Eysnek and Freidman)، and chronic fatigue (Barton et al.) questionnaires were used to assess research variables. IgM was determined with nephelometric method. Data were analyzed using Pearson''s correlation coefficient and structure equation modeling. Neurosis، introversion and A type personality correlated significantly with chronic fatigue (P < 0. 01). Type A personality and neurosis correlated with serum IgM level، too (P < 0. 01). Indirect effect of neurosis، introversion and A type personality on serum IgM level was significant (P < 0. 01). This research argued employees with neurosis، A type personality، and introversion traits are talented for reducing serum IgM level.

Producing IL-17, Th17 cells induce BAFF and APRIL, two important mediators for B-cell survival and activation. Common variable immunodeficiency (CVID) is a group of many primary immunodeficiency diseases with a common set of features (including hypo-gammaglobulinemia) and different underlying causes. The prevalence of CVID is 1 to 50,000. Hence, the aim of this study was to measure IL-17 gene expression in peripheral blood of patients with CVID.

Total mRNA extracted from whole blood samples of 10 patients with CVID and 10 normal controls; then, IL-17 gene was measured using qRT-PCR.

There was a slight decrease in transcript levels of IL-17 in patients with CVID, even though, it was not statistically significant (P = 0.195).

We showed that IL-17 is decreased in patients with CVID and this could be an explanation for their humoral immunity response insufficiencies. Absence of statistical significance in this IL-17 reduction may be due to our sample size and increasing the number of samples may result in statistical significance of this in future studies.