مرتضی عبداللهی

Ectopia cordis is a congenital anomaly. In this disorder, the heart is located completely or partly outside its original location in the chest. This deformity has three cervical, thoracic, and abdominal forms and the neck form is the most common form. Up to now, many factors such as genetic defects, the receipt of chemical products (mercury, cocaine, ethanol), the consumption of teratogenic plants, exposures to radiation, infectious agents (such as BVD virus), and the use of medications (calcium suppressants) have been known factors in Ectopia cordis occurrence. Immediately after birth, a female Holestein was referred to a veterinarian clinic in Semnan City Iran,. During the clinical examination, according to the location of the heart outside the body and under the sternum, ectopia cordis anomaly was detected.

The Ministry of Health and Medical Education for the first time drafted and communicated the National Nutrition and Food Security Document in order to implement targeted programs. This study aims to evaluate the provincial nutrition and food security document and outline strategies to improve the efficiency and effectiveness of provincial document deployment at the organizational, inter-organizational and community level.

Documents received by the universities / colleges of medical sciences were classified for evaluation purposes. The studied dimentions consisted of the provincial document cut-off, the beneficiaries of the program, the establishment and implementation of the submitted documents. In the next step, self-declaration compliance assessment and scoring were performed.

Out of 28 provincial documents (90%), 60% were documented, 21% provincial data were not used, and desirable measures were taken to attract stakeholders. No effective measures were taken to evaluate the results as the most important pillar of the document. Among 255 projects anticipated, 7 were documented and 6 were approved, and only 4 projects were submitted to the researchers, and for 5 projects had written

Despite the relatively favorable performance in most of the documented and targeted areas of the document at the national level, assessments show that this trend has not been very successful at the provincial level. This study clearly shows policy makers' lack of support for nutrition programs and poorly evaluates nutrition support.

To accurately estimate the Covid-19 morbidity and mortality, it is necessary to convert the raw data to the incidence and fatality rate.The purpose of this study is to analyze the incidence and Fatality rate of Covid-19 in the world by countries and six regions of the World Health Organization (WHO). By reporting incidence and Fatality rate instead of morbidity and mortality, a more accurate and realistic understanding of the incidence and fatality due to Covid-19 is obtained, which allows comparisons between countries.

In this cross-sectional study, cumulative numbers of incidence and fatality due to Covid-19 for all countries of the world were extracted from the start of pandemic to august 2021. Sources included data published by the WHO, Ministry of Health and Medical Education of Iran. The World Bank and United Nations websites were used to calculate world morbidity and mortality rates.

The total number of reported cases worldwide is 191,773,590. Iran ranks 13th in the world with 3,603,527 reported cases. However, the incidence of the disease is 24.6 per 1000 population in the world, 16.4 in the Middle East and North Africa (MENA) region and 42.9 in Iran. The incidence of the disease in Iran is 74% higher than the global average and 162% higher than in the MENA, respectively. However, Iran rank is 87th among all countries. The fatality rate due to COVID-19 calculated 2.4 % in Iran. The fatality rate in Iran is higher than world (2.15%) and five WHO regions (1.22-2.10%) except NENA region (3.26%). Iran in terms of fatality rate is ranked 67 in the world. However,the fatality rate has decreed from 5.4% in October 2020, which was ranked second in the world after Mexico.

From the beginning of the Covid-19 epidemic until August 1400, the incidence of the disease in Iran is higher than the global average and the four regions of South-east Asia, MENA,the western Pacific and Africa, but less than the Americas and Europe. In terms of fatality rate, Iran’s rate is higher than the global average and five regions of the WHO, and only less than the MENA region.

Background and Purpose:

Pica is a metabolic disorder characterized by frequently signs such as licking surfaces, lickling walls, licking body cover of other animals, feeding non-nutrients and lacking nutritional value such as soil, wool, hair, bone, walls, wood, plaster, bark, Stools, carcasses and urine of other animals. Pica has side effects like reduces growth rate, weakening body resistance to infections due to weakened immune system, dental damage, electrolyte imbalance, formation of trichobezoar in the reticulorumen and abomasum, occurrence of some toxicities such as lead poisoning, gastrointestinal impaction with foreign substances, esophageal perforation, intestinal obstruction, and botulism. Pica has been reported in human, calf, sheep, cattle, camel, pig, cat, mice and lamb. Precise etiology for Pica has not been reported even in humans, but it has been linked to deficiencies in phosphorus, iron, zinc, copper and other minerals. Cyanoferin is one of the common drug in Iran's livestock industry and manufactured by Nasr Pharmaceutical Company (Fariman, Torbat Jam, Khorasan Razavi, Iran). Each milliliter of this drug contains 100 mg of dextran iron and 100 µg of cobalamine. The aim of this study was to evaluate the effect of intramuscular injection of cyanocobalamin-iron dextran (cyanoferin) on primary parameters of hemogram and serum minerals in 20-day-old with pica goat kids.

Based on previous studies, the appropriate sample size for the study was determined. Ten 20-day-old male and female mixed-breed goat kids with Pica and ten 20-day-old male and female mixed-breed goat kids without Pica were selected from Baseri goat farm in Ahovan area of Semnan, Iran. In this selection, detection of goat kids with Pica was performed by observing the goat kids in the sheepfold for 4 days, and the goat kids repeatedly showing the eating behavior of the sheepfold wall and licking the manger and surfaces, considered to with Pica. Then, under sterile conditions, 5 ml of blood was taken from each goat kids jagular vein and immediately 1 ml of this blood was poured into a sterile heparinized tube and the remaining 4 ml poured into a tube without anticoagulant. These samples were transferred to the laboratory of the Faculty of Veterinary Medicine in Semnan University in the vicinity of ice for 2 hours, where their hemogram indices and serum mineral concentrations were measured immediately. The tests revealed that goat kids with Pica only suffer from iron deficiency and anemia. The without pica goat kids received isotonic saline treatment (a deep intramuscular injection, 3 ml) and the with pica goat kids received cyanoferin treatment (a deep intramuscular injection, 3 ml). Ten days after treatment, hemogram indices and serum mineral concentrations of all under experiment goat kids were measured. SPSS software version 22 was used for statistical analysis. Repeated measures ANOVA with Tukey post hoc test at 95% confidence level were used to investigate the differences between the groups.

In patients with Pica blood PCV, MCV and Hb and serum iron was less than nonpatients, significantly (p=0/001). Treatment with cyanoferin increased the blood PCV (p=0/002), MCV (p=0/001) and Hb (p=0/001) and serum iron levels (p=0/001), significantly and Pica was treated in patients. The most important consequence of iron deficiency in the body is anemia because more than half of the body's iron is found in hemoglobin and relatively lower amounts are found in myoglobin and the enzymes involved in oxidative metabolism. Ruminant infants, such as calves, lambs and goat kids require large amounts of iron to build components such as hemoglobin, myoglobin, and enzymes involved in cellular respiration due to their high daily growth coefficient. Despite these infants' high need for iron, their mother milk is iron deficient. Thus, ruminant infants who fed only milk and have a low liver stock of iron are at high risk for iron deficiency anemia. In the of sheep and goats herds of the United States and Europe, lamb and goat kids IDA (iron deficiency anemia) is a very important serious phenomenon, so that in these countries, 24 hours after birth, by injecting a 300 mg of dextran iron into lambs and goats, They counteract with this phenomenon and prevent the occurrence of iron deficiency. It has been shown that this amount of dextran iron administration improves blood status and weight gain at times and in lambs and goat kids.

The present study showed that iron deficiency anemia is related with Pica in 20-day-old goat kids and this pica was treated with an intramuscular injection of 3 ml of cyanoferin (300 mg of dextran iron plus 300 µg of cobalamin). It is recommended to evaluate the effect of oral and parenteral iron supplementation on parameters such as appetite, feed intake, weight gain, growth rate, immune status and lymphocyte defense in goat kids.

High intakes of saturated and trans fatty acids can increase risks of cardiovascular diseases and cancers. Therefore, removal of partially-hydrogenated vegetable oils containing trans fatty acids has been suggested as one of the most effective health interventions. The aim of the current study was to investigate the policy effects of decreasing trans fatty acids in partially-hydrogenated vegetable oils as well as increasing intakes of unsaturated fatty acids through the introduction of novel products into the market and assessing the averages intake of saturated and trans fatty acids by households of capital cities in West Azerbaijan, Fars, Khuzestan, Lorestan, Semnan and South Khorasan Provinces.

This cross-sectional descriptive study was carried out on households in capitals of six provinces. Data were collected from the begging of May to the end of July 2014 using telephone interviews. Information on the types of fats and oils used for cooking as well as the purchase pattern and their quantities were collected using questionnaires. Fatty acid profiles of the consumed fats and oils were investigated as well.

The commonly consumed oils in the provinces included partially-hydrogenated vegetable oils, blended oils and frying oils. These oils included more than 70% of the total oil intakes. Furthermore, the average intakes of oils and fats per capita in the provinces were ordinarily West Azerbaijan, Khuzestan, Lorestan, South Khorasan and Fars. Intakes of trans fatty acids ranged from 0.32 in Fars to 0.67 g/person/day in West Azerbaijan. Results of this study showed that quantity of the trans fatty acids in partially-hydrogenated vegetable oils  has decreased by 95%, compared to that in previous decade. Moreover, consumption of partially-hydrogenated vegetable oils by households has decreased by 45%, compared to that in the last decade.

Effective policies, reformulations of oils and decreasing of trans fatty acids in partially-hydrogenated vegetable oils have included positive and effective changes, which have led to improve quality of fats and oils consumed by the households.

Dietary diversity score is a nutrient intake adequacy index associated with the child growth. As mothers make the most important decisions affecting dietary patterns for their families and children, this study investigated possible relationships between the dietary diversity scores of children and mothers and the anthropometric statuses of preschool children for the first time in Iran.

In total, 236 children and their mothers participated in this cross-sectional study. Data about mothers and children weight, height and dietary diversity scores were collected using food recall questionnaires and dietary diversity questionnaires, respectively. Then, mothers and children were categorized into good, medium and weak dietary diversity score groups based on the protocols by the United Nation Food and Agricultural Organization. Furthermore, households were categorized into three major groups (low, middle and high) based on their socioeconomic statuses.

This study showed that child weight-for-age (p = 0.013) and weight-for-height (p = 0.03) included significant relationships with the mothers dietary diversity scores.

The better the mothers dietary diversity scores were, the more likely they were to have children with normal weight for height, weight for age and height for age values, compared to mothers with low dietary diversity scores.

Inappropriate gestational weight gain (GWG) may increase risk of adverse pregnancy outcomes. To prevent these risks, determining optimal weight gain is a priority in prenatal care. The objective of this study was to determine the GWG of women referring to health centers for their prenatal care visits in Tehran in 2016.

This cross-sectional study was conducted in Tehran, Iran. The study population included all pregnant women receiving prenatal care visits from April 2016 to March 2017 in 12 health centers affiliated to Shahid Beheshti and Iran Universities of Medical Sciences. The sampling method was census and a total of 232 people were surveyed. Data were analyzed by SPSS software version 23 using statistics of frequency, mean and standard deviation. To investigate the relationship between variables, correlation method was used by using Pearson's correlation coefficient at a significance level of 0.05.

The mean (SD) of age of women was 28.6 (5.4) with a range of 18 to 40 years. According to the pre-pregnancy body mass index, among 220 pregnant women, 6 (2.7%) were underweight, 112 (50.9%) were normal, 78 (35.4%) were overweight, and 24 (11%) people were obese. The mean (SD) of GWG was 11.7 (4.3) kilograms and among 177 pregnant women, 76 (42.9%) had GWG within, 55 (31.1%) had GWG below and 46 (26) had GWG above guidelines.

The prevalence of GWG above guidelines was higher in overweight and obese women than underweight and normal women in this study. Therefore, achieving the appropriate weight before pregnancy and close monitoring of weight gain during pregnancy is recommended.

Lifestyle and its various components have multiple effects on human health and disease. These include dietary intakes and nutritional patterns, which can greatly prevent non-communicable diseases by adhering to dietary recommendations and guidelines. One of the most important and practical studies, showing relationships between the diets and diseases and the level of health in each country, is the cohort design of the study that can show the trend of changes in incidence and exposure over time. Design of the Iranian teacherschr('39') cohort, which specifically investigates relationships between the food intake, nutritional status and physical activity and the incidence of non-communicable diseases, began in 2001. To design the study and compile the questionnaire, advices of Dr. Walter Wilt from Department of Epidemiology, Harvard School of Public Health, USA, were used. This study was carried out in collaboration with the Office of Community Nutrition Improvement, the Office of Health and Wellness of the Ministry of Education and the Center for Research on Social Determinants of Health, Iran. The choice of teachers was due to their ability to understand and answer questions. The self-administered questionnaire was developed based on the data from the Institutechr('39')s 2000–2002 national food consumption survey as well as statistical methods to investigate food items and their portion sizes. In a pilot study on 1000 teachers in Tehran, the feasibility of the study was verified. In general, follow up of outcomes in teachers includes fewer barriers due to their use of national insurance services.

Transfer of immunoglobulin from mother to baby through placenta or colostrum is called passive transfer (PT). The ruminant placenta is a syndesmochorial type and is a barrier against the transfer of maternal immunoglobulins from the blood to the infant. Therefore, in ruminants, the inability to transmit colostrum immunoglobulins is called Failure of Passive Transfer (FPT). This study aimed to determine the percentage of FPT in lambs and kids in Garmsar County and the effect of factors such as race, gender, mother's age, mother's parturition and type of livestock (lamb or kid) on FPT. This study was performed on 101 healthy 2-4 day-old lamb and kid in 10 herds of sheep and goats in Garmsar County. After examination, confirmation of clinical health, sex, age, race, birthday time, number of mothers, parturition, maternal age and newborn weight, 3 ml of sterile blood was obtained from the jugular vein. These samples were immediately referred to the lab in without anticoagulant tube and adjacent to the ice. The biuret method and Zn-sulfate turbidity test were determined on the level of total protein and immunoglobulin G serum. The results of this study revealed 50/50% occurrence of FPT in the lambs and kids understudy, the relationship between race and sex with the incidence of FPT, and the lack of relation between maternal age, mother's parturition and type of livestock with the incidence of FPT.

Abomasal hypomotility plays an important role in pathogenesis of some abomasal disorders such as abomasal bloat which has the same serious side effects associated with using synthetic drugs for its treatment, such as diarrhea and antibiotic resistance. To decreasing these side effects, administration of herbal medicine is a good way.

To determine the effect of oral administration of turmeric aqueous extract on rate of abomasal emptying rate in neonatal lambs.

This study was conducted on twelve five-day-old Sangsari-female-lambs (average weight 3 kg). All lambs received five oral treatments, including saline (30 ml), erythromycin (400 mg), turmeric 200 mg/kg, turmeric 250 mg/kg, and turmeric 300 mg/kg, respectively. At 0, 30, 60, 90, 120, 150, 180, and 240 minutes after each treatment, plasma samples of lambs were taken. The rate of abomasal emptying was determined with acetaminophen absorption test.

Treatment with erythromycin and three different doses of aqueous extract of turmeric (200, 250, 300 mg/kg) increased the rate of abomasal emptying in comparison to the negative control treatment, significantly (P<0.05). The stimulatory effect of erythromycin on abomasal emptying was higher than aquatic extract of turmeric, significantly (P<0.05). No clinical side effects were observed following the administration of erythromycin and turmeric in lambs.

This study showed that aqueous extract of turmeric has a stimulatory effect on lamb's abomasal emptying but more studies are needed on the effect of this plant’s components on abomasal emptying.

Pica is one of the disorders that has high potential for inducing various damages such as poisoning, digestive accumulation, botulism, weakening of the immune system, weight loss, etc. in ruminants farms and for years, the researcher has encountered this problem in lambs. The present study was conducted to compare the effect of Microvit supplementation and Ferrodrop oral drops on the primary parameters of homogram and serum minerals in 20-days-old healthy and with Pica lams. This clinical trial was performed on 10-headed 20-days-old lambs mixed-breed without Pica and 10-headed 20-day-old lambs mixed-breed with Pica. Both groups received 2 types of oral therapy including Microvit supplementation (7 days, 0/5 g / l of consuming water) and oral furuderap drops (4 days, 300 mg/day in consuming milk). Before starting treatment and after each treatment, blood and serum samples were taken from lambs and sent to the laboratory for determination of CBC and serum mineral elements. Data were analyzed by SPSS statistical software using repeated measures ANOVA at 95% confidence level. In patients with Pica blood Hb, MCV and MCHC and serum iron was less than nonpatients (p0/05), and Pica was not treated in patients (p>0/05). Treatment with furuderap increased the blood Hb, MCV and MCHC and serum iron levels, significantly and Pica was treated in patients (p

Abomasal hypomotility plays an important role in pathogenesis of some abomasal disorders such as abomasal bloat that there are same serious side effects associated with using synthetic drugs for its treatment, such as diarrhea and antibiotic resistance and for decreasing these side effects, administration of herbal medicine can be appropriate approach. Evaluating effect of Folus fruit aqueous extract on lamb,s abomasal emptying is goal of this study. This study was conducted on twelve five-day-olds Sangsari-female-lamb (average weight 4 kg). lambs received five oral treatments including salin (30ml), Eeythromycin (400 mg), Folus (700 mg/kg), Folus (750 mg/kg) and Folus (800 mg/kg), respectively Acetaminophen absorption test was used to evaluating the rate of abomasal emptying. After drawing relational model between plasma Acetaminophen concentration and time with regression method showed that treating with erythromycin and three different doses of aqueous extract of Folus fruit (700, 750, 800 mg/kg) increased the rate of abomasal emptying in comparison to the negative control, significantly (P<0.05). No clinical side effects were observed following the administration of erythromycin and Folus in lambs. This study showed that aqueous extract of Folus fruit has a stimulatory effect on lamb's abomasal emptying but more studies are needed on the effect of this plant components on abomasal emptying.

The average age of women with breast cancer in Iran is at least 10 years lower in comparison to developed countries and the incidence of the disease in Iranian women is on a rise. According to studies, diets that are diverse in food groups can play a role in protecting against chronic diseases including cardiovascular diseases and cancer. Diet diversity score is an indicator used to measure diversity between and within food groups. This study aimed to assess the relationship between diet diversity score and breast cancer risk. This case-control study was carried out from April 2014 to February 2015 at Shohada Hospital in Tajrish, Tehran. Demographic and anthropometric data of 298 participants including 149 breast cancer cases and 149 apparently healthy women were collected. A valid food frequency questionnaire containing 168 food items was completed to assess usual dietary intake through face to face interviews. Energy was calculated using Nutritionist 4 software (First Databank Inc., Hearst Corp., San Bruno, CA, USA) and diet diversity score was calculated using five food group scoring. Odds ratios with 95% confidence intervals were obtained using logistic regression test to evaluate the association between breast cancer risk and diet diversity score tertiles. There was no significant difference in weight, height, body mass index between the two groups, but physical activity level and daily energy intake showed a significant difference (P<0.001). After adjusting for the effect of confounding variables including energy, body mass index, physical activity, menopause status, family history of breast cancer, contraceptive use, number of pregnancy, age of menarche and smoking, the risk for developing breast cancer was 86% lower in those in the highest tertile of diet diversity score compared to those in the first tertile (OR=0.14, 95% CI=0.06-0.31). An inverse and significant association was found between breast cancer risk and diversity scores of fruits and milk groups (P<0.001). Higher diet diversity score is associated with reduced risk of breast cancer.

Pica refers to an abnormal appetite due to various nutrition causes that imposes heavy losses to the cattleculture industry every year. One outbreak of pica in the several marginal dairy farms of Varamin city made us to investigate and research about causes,treatment,control and prevention of this disorder. This Clinical trial was performed on 35 stricken and 30 healthy Holstein calves (30-50 days old). The calves were devided to groups include first control (30 calves without Pica), first Treatment (35 calves with Pica) , second control (the calves of first control group after treatment) and second treatment (the calves of first treatment group after treatment). Before and after the receiving treatment (2 dose of 500mg than iron drop with one week interval), blood samples were taken from every 65 calves and to determine the CBC and the levels of the blood mineral elements was sent to the laboratory. Datas were analyzed by SPSS statistical software, F test with the significant level of P

Aim and Based on existing scientific information Thymus vulgaris is a medical herb which has anti- inflammatory effects. Visceral pain is an unpleasant feeling, however its treatment with NSAIDs results in serious side effects such as gastric ulcer, blood dyscrasia and Renal failure. In order to decrease these side effects and the dosage of drugs, co-administration of synergistic herbal medicine with these drugs can be a solution. The aim of this study was to evaluate the palliative interactive effect of hydroalcholic extract of Thymus vulgaris and Flunixinmeglumine on visceral pain.
Methods and Materials: This experimental study was performed on 40 N-MRI male mice (36±4g).Animals were randomly divided into five groups: Negative Control group treated with normal saline, Positive Control group treated with Flunixin (2 mg/kg) and treatment groups receiving Flunixin (1mg/kg), Thymus vulgaris(100mg/kg) and both Thymus(100mg/kg) plus Flunixin(1mg/kg). All these groups received drugs and hydroalcholic extracts via intraperitonial injection. The Mices were injected with acetic acid 0.6% (10ml/kg) for visceral pain induction, and 15 minutes after each intraperitoneal administration, palliative effects were recorded by counting the number of Writhing during 30 minutes. The data was analyzed by SPSS using One-Way ANOVA (Tukey) test. The significant value was shown with p Findings: The positive control group and treatment groups showed a significant reduction in pain response when compared to negative control group (p>0.001). Both Postive control and Thymus-Flunixin groups had a significant reduction in pain response in comparison with both Flunixin and Thymus groups (p0.001).
Co-administration of Thymus vulgaris and Flunixin results in synergistic analgesic effect.

Breast cancer is the second most common cancer worldwide and the most common cancer among women and notably the fourth leading cause of death worldwide. Overweight and obesity are two main risk factors which have been proven the creation of breast cancer after menopause. Therefore, this study aimed to investigate the relationship between anthropometric and body composition in pre-menopausal and post-menopausal breast cancer risk.
In this case-control study, 88 patients with breast cancer (n = 48 pre-menopausal and post-menopausal 41) and 86 controls (45 premenopausal and 41 postmenopausal) who were matched by age, studied respectively. The cases, women who were admitted to Shohada Hospital recently diagnosed with breast cancer and had not chemotherapy or radiation therapy. The controls of women who were admitted to the same hospital had no history of any type of cancer or hormonal disease. The subjects were studied anthropometric indices and body composition was also measured by tanita Body Composition analyzer. For analysis the findings, chi-square and logistic regression was used.
In the study of case and control groups separately menopausal status, in pre-menopausal population, overweight women (BMI=24/91-29/9kg/m2) had lower odds ratio of developing breast cancer (OR=0/23 CI=0/84-0/06). In postmenopausal population with waist-to-hip ratio (0/80-0/84), WHR was significantly associated with breast cancer risk (OR=0/09 CI=0/60-0/02).
In this study, premenopausal overweight women had lower odds ratio of developing breast cancer. High WHR was associated with breast cancer risk in postmenopausal women.

Breast cancer is the most common cancer among females in the world. Identifying the nutrients that modify the risk of the disease is one of the key strategies for improving the quality of life and reducing treatment costs. Epidemiological studies support the role of macronutrients and vitamins involved in one carbon metabolism in the etiology of the disease. This study aimed in investigation of the relationship between the intake of macronutrients and vitamins involved in one carbon metabolism with breast cancer risk.
This case-control hospital base study was conducted at Shohada Hospital, Tehran from April to February 2015. Demographic data, physical activity level and nutrients’ intake from diet and supplements were collected through interview from 151 cases and 154 controls. Dietary intake was assessed by a valid and reliable 168-item semi-quantitative food frequency questionnaire. Then intake of macronutrients and B vitamins was assessed by Nutritionist 4 software (First Databank Inc., CA, USA). Comparing categorical variables between the two groups was done by Chi-squared test and the relationship between intake of studied nutrients and risk of breast cancer was determined using logistic regression test.
There were no difference in age, menarche age, menopause age, body mass index (BMI), number of live births between two groups. But the difference in physical activity, energy intake, marital status, educational level, occupation, oral contraceptives use was significant (P The results showed that high intake of protein, fiber, vitamins B2, B6, B12 and folate are associated with lower risk of breast cancer.

Colorectal cancer is the third cause of cancer death in the world and also in Iran. Recent studies in Iran show that colorectal cancer incidence has increased dramatically in the three recent decades. The current review was conducted to investigate the effect of dietary conjugated linoleic acid and serum Visfatin levels on the risk of developing colorectal cancer.
PubMed, Google scholar, ISIwebofknowledge and Scopus were searched for studies published between 2000 till 2015. “NAMPT”, “Visfatin”, “PBEF”, “Rat”, “Conjugated linoleic acid” in combination with “Colorectal”, “Cancer”, “Neoplasm” and “malignant” were used as search terms. Clinical trials with high quality and review articles were collected.
Various studies show that conjugated linoleic acid (CLA) prevents metastasis and progressive cancers especially colorectal cancer by different ways such as inducing apoptosis and aggregating of tumor suppressor proteins. It has been concluded that the serum Visfatin levels increase in different cancers and a positive correlation between serum Visfatin levels and metastasis has been shown.
It is suggested that reduction of serum Visfatin level as a key point in controlling cancer is a novel approach to prevent malignancy. For this purpose dietary CLA is suggested as a powerful factor to decrease serum Visfatin.

Colorectal cancer (CRC) is one of the most common types of cancer affecting 1.23million individuals per and is the third most common cancer in males and the second in Females. In addition¡ it is the third most common cause of cancer-related death.In recent years Oxidative stress and Chronic inflammation are believed to be two of the risk factors of colorectal carcinogenesis that have an important role in colorectal cancer(CRC). Biological and epidemiological studies indicated that some factores such as diet an life style can prevent incidence of CRC.Conjugated linoleic acid (CLA) is one of the functional lipids and is known to have physiological benefits such as the prevention and attenuation of lifestyle-related Colorectal cancer.
PubMed¡ Google scholar¡ ISI webofknowledge and Scopus were searched for studies published between 2000 till 2015. “inflammatory”¡ “anti oxidant”¡ “Rat”¡ “Conjugated linoleic acid” in combination with “Colorectal”¡ “Cancer” were used as search terms. Clinical trials with high quality and review articles were collected.
it is suggested reduction of inflammatory factors level as a key point in controlling cancer is a novel approach to prevent malignancy. For this purpose dietary CLA is suggested as a powerful factor to decrease inflammatory factors and increase anti oxidant factors level.

Colorectal cancer (CRC) is one of the most common types of cancer affecting 1.23 million individuals per year in the world. Recently, it is suggested that inflammation and oxidative stress play an importmat role in colorectal carcinogenesis. The aim of this syudy was to examine the effects of dietary conjugated linoleic acid (CLA) on oxidation markers and antioxidant defenses level in a rat model of colorectal cancer.
Sixteen male Wistar rats, weighing 250-300 g were divided into two groups: control and experimental. Both groups were injected subcutaneously, with 1,2- Dimethyl Hydrazine at a dose of 15 mg/kg of body weight, twice per week for 6 weeks. The control group and experimental groups were gavaged with water (2 ml/kg) and CLA (200 mg/kg), respectively, for the first 4 weeks of study. After 6 weeks, the rats were killed and their blood and colorectal tissues were collected. The serum levels of superoxide dismutase (SOD), glutation peroxidase (GPx), paraxonase (PON) and myeloperoxidase (MPO) and also malondialdehyde (MAD) level in the colorectal tissue were measured.
Findings indicated that MAD and MPO levels significantly decreased in the experimental group in comparison than the control group (P our findings suggest that CLA is a powerful substance which decreases oxidation markers, and increases antioxidant defenses in colorectal cancer

Visceral pain is unpleasant felling that Using synthetic drugs for treatment has some side effects, such as psychological dependence and blood dyscrasia and for decreasing these side effects, administration of herbal medicine can be appropriate approach. Based on existing information in traditional medicine and some recent scientific surveys, Ferula gummosa plant is one type of herbs that has different therapeutic effects of which it is possible to point to antibacterial, antifungal, antioxidant and anti-inflammatory effects.The aim of this study is evaluation of palliative effect of Ferula gummosa on visceral pain.
This experimental study was done on 40 NMRI male mice. (36±4g). Mice were divided randomly into control group, positive group (flunixine), treatment 1 , treatment 2 ,treatment 3. Respectively Control group and positive group received normal salin and flunixine (2mg/kg) and also treatment groups respectively received 25, 50 ,100 mg/kg of Ferula gummosa intraperitoneally. 15minute after each injection , for visceral pain induction , mices were injected by acetic acid 0.6% (10mg/kg) and during 30 minutes, the analgesic effect was recorded by counting the number of Writing. Datas were analyzed by SPSS statistical software , One-Way ANOVA and Tukey test with the significant level of P The extracts of Ferula gummosa with 25, 50, 100 mg/kg doses in compared with negative control doesn’t induced a significant reduction in pain response (P This study confirms that Ferula gummosa had no palliative properties on visceral pain. But further studies are necessary to find out an Analgesic effect of its components.

Colorectal cancer is the third causes of cancer death in the world. Recent studies have shown that the serum levels of visfatin are increased during malignancies, suugesting a role for vistatin in pathogenegis of malignancies. It is suggested that conjugated linoleic acid, (CLA) can reduce the serum levels of vistatin. The aim of this syudy was to study the effects of dietary conjugated linoleic acid on serum visfatin level in rat model of colorectal cancer.
Sixteen male Wistar rats, weighing 250-300 g were divided into two groups: control and experimental. Both groups were injected subcutaneously, with 1,2- Dimethyl Hydrazine at a dose of 15 mg/kg of body weight, twice per week for 6 weeks. The control group and experimental groups were gavaged with water (2 ml/kg) and CLA (200 mg/kg), respectively, for the first 4 weeks of study. After 6 weeks, the rats were killed and their blood and colorectal tissues were collected in order to analyze serum visfatin, tumor number and tumor size respectively by ELISA method, tumor numbering and macroscopic analysing.
Visfatin levels decreased dramatically in the experimental group than control group (P=0.001). Tumor number and tumor size increased considerably in the control group than experimental group (P = 0.000). There was a positive correlation between visfatin levels with tumor number (r =0.701, p = 0.001) and also between plasma visfatin with tumor number×tumor size (r=0.771, p=0.000).
This study shows that dietary CLA by reducing serum visfatin can decrease the tumor number and tumor size in rat model of colorectal cancer. Thus, CLA suppresses colon carcinogenesis by a mechanim probably involving reduced serum visfatin

Studies suggest a possible protective role of vitamin D against breast cancer. This study aimed to assess the relationship between vitamin D intake and risk of breast cancer in Iranian women. A total of 135 new cases of breast cancer and 135 matched controls were included in the study. The data on breast cancer risk factors، sunlight exposure and use of vitamin D supplements were obtained through demographic questionnaire. To measure the intake of energy، macronutrients، calcium، and vitamin D we used a 168-item semi-quantitative food frequency questionnaire. The mean dietary intake of vitamin D in the cases was significantly lower than the control group (24 vs. 30. 56 IU/day) (P=0. 001). The risk of developing breast cancer was 2. 5 times (61%) lower for those in the highest quartile of dietary intake of vitamin D compared to those in the first quartile (OR=0. 392، 95%CI=0. 196-0. 784). This inverse association was marginally significant in the premenopausal women (OR=0. 39، 95%CI=0. 151-1. 006)، but not in the postmenopausal women. Overall، the total intake of vitamin D from foods and supplements was not associated with breast cancer risk، in both the premenopausal and postmenopausal women. Dietary intake of vitamin D may have a protective role against breast cancer، especially in premenopausal women.