فهرست مطالب مینا رحمت اللهی

AKT, PI3K and IL-1 are related to diabetes and cardiac inflammatory. The aim of this study was to investigating cardiac inflammatory markers via AKT, cardiac PI3K gene expression and serum IL-1β with combined exercise and consumption of taurine supplementation in diabetic male Wistar rats.

in this experimental study, 30 male adult Wistar rats weighing 250-300 grams and 6 weeks old were randomly divided into 3 groups including: diabetic exercise+supplement group (T+S) (10 rats), diabetic control group (CD) (10 rats), and healthy control group (CH) (10 rats). To make rats diabetic, 55 mg/kg body weight of streptozocin was injected. Blood sugar above 250 mg/dL was considered as diabetes. Combined exercises and taurine supplementation were performed for eight weeks and 5 times a week. Taurine supplement was taken as a 1% solution in water daily. To compare the inter-group and intra-group changes of the variables, two-way ANOVA and Tukey's follow-up were used. The significance level was 0.05.

PI3K gene expression was significantly increased in the diabetic exercise+supplement group compared to the diabetic control group (P=0.001). The serum level of IL-1β factor in the diabetic exercise-supplement group had a significant decrease in comparison with the diabetic control group (P=0.001). However, there was no significant change in AKT gene expression in the diabetic exercise+supplement group compared to the diabetic control group.

It seems that combined exercises with consumption of taurine supplementation may lead to the improvement of heart inflammatory factors in diabetic people while increasing PI3K, decreasing IL-1β and creating favorable changes in glucose metabolism. Therefore, it is suggested to use combined exercises and consumption of taurine as a non-invasive and low-cost method in improving cardiac inflammatory markers in diabetic persons.

Adipolin (CTRP12), which improves insulin sensitivity, is a novel anti-inflammatory adipocytokine secreted from adipose tissue. In this study we aimed to assess the Adipolin and Insulin Resistance index (HOMA-IR) response to two types of exercise in type 2 diabetic male rats.
In this study, 24 diabetic Wistar rats (Induced by high-fat diet and Streptozotocin(stz) injection) were randomly assigned to 3 groups: High intensity interval exercise (HIIT), low intensity continuous training (LICT) and control (C). Both training groups were trained on the treadmill, 5 sessions per week for 8 weeks. Blood samples were taken 24 hours after the end of training session and plasma adipolin, insulin and glucose levels were measured. ANOVA and Tukey post hoc tests were used to analyze data and the level of significance was considered to be p≤0.05.
Data analysis showed that plasma adipolin levels in the low intensity continuous training group were significantly increased, compared to the control group (p=0.006). Plasma glucose level in both the low intensity continuous training and the high intensity interval groups was significantly decreased, compared to the control group (p=0.049) & (p=0.007). Plasma insulin level in both training groups was increased and HOMA-IR index was decreased, compared to the control group, although changes were not significant.
The results of this study showed that exercise training can increase plasma adipolin in rats with type 2 diabetes, changes however that are partially dependent on the type of exercise training.