فهرست مطالب ناهید بلادی مقدم

Physical activity is one of the promising interventions with positive effects on the quality of sleep and cognitive function in multiple sclerosis (MS) patients. With the development of various physical programs, including physical-cognitive combined training,, it seems that these dual interventions may better affect neurodegenerative diseases, such as MS. In the same direction this study aimed to investigate the quality of sleep and psychomotor Vigilance of patients with MS by performing combined aerobic-cognitive training (Brythonic) and conventional aerobic training (Aerotonic).

30 patients (22 women and 8 men) with Relapsing-Remitting and Expanded Disability Status Scale (EDSS) less than four, an average age of 36.66±9.36 years, average height of 164.5±6.30 cm, average weight of 65.43 ± 9.80 kg and average body mass index 24.02 ± 3.02 kg/m2 were randomly divided into 3 groups of 10 people: Brythonic training, Aerotonic training, and control without training. Two groups, Brythonic and Aerotonic, during 10 weeks (20 sessions), two sessions per week, performed relevant online training at home, including 10 minutes of warm-up, 15 to 35 minutes of physical activities, and five minutes of cool-down. In the pre-test and also after 10 weeks of online practice at home (post-test), psychomotor vigilance test (PVT), and Pittsburgh Sleep Quality Index (PSQI), volunteer patients were measured. All the procedure was conducted under the supervision of neurologist with precision. Descriptive statistics (mean ± standard deviation) were used to analyze the data. To investigate the difference between the three groups and the intra-group differences before and after the training period, the repeated analysis of variance test with between-group factor was used and the significance level was considered P≥0.05.

Despite observing a relative improvement in most variables of the PVT test in the Brythonic group compared to the Aerotonic and control groups, these changes were not significant. Also, in the PSQI test, even though a 1-point improvement was observed in the sleep quality of patients in the Brythonic and Aerotonic groups, the changes were not significant.

This study showed that although the repetition of motivational words with aerobic movements in a short training period does not have a significant effect on the quality of sleep and the levels of psychomotor vigilance of patients with MS, due to the improving trend in the Brythonic training group, it is probably suggesting that significant changes in these variables may require more duration or intensity of exercise or cognitive interventions..

Assessment of walking ability and fall risk in people with multiple sclerosis is often performed in rehabilitation. DGI is one of the tools that evaluate walking during various tasks. The aim of the present study was to evaluate the validity of the Persian version of DGI in people with multiple sclerosis.
The current study was performed using methodology method, and 62 patients were selected based on non-probable sampling. To check criterion validity, the correlation between the Berg Balance Scale scores and dynamic gait index scores were calculated and construct validity was evaluated using factor analysis. Also, content validity was assessed by 10 rehabilitation specialists with experience in the field of research and clinical work and in quantitative way.
The results showed that the Persian version of dynamic gait index in people with MS has an acceptable criterion validity with the Berg Balance Scale (r=0/859). Content validity ratios for each item were between 0/80 and 1/00 and content validity index were 0/91, which were in the acceptable range. According to factor analysis, the test is composed of one factor with the eigenvalue of 4.4, which predicted 55% of the variance.
The Persian version of dynamic gait index is a valid measure to assess the dynamic balance while walking in patients with multiple sclerosis.

To compare peripapillary retinal nerve fiber layer (RNFL) thickness among multiple sclerosis (MS) patients with or without a history of optic neuritis (ON) and a healthy control group. In this retrospective case-control study, 59 MS patients were recruited from a neurology clinic of Imam Hossein hospital. Of which, 36 patients had at least one episode of ON and 23 others had no history of ON. Control group included 30 healthy individuals. Peripapillary RNFL thickness was measured in all cases using Stratus spectral domain optical coherence tomography (OCT). Average RNFL thickness was significantly lower in MS patients with a history of ON compared to MS patients without ON (86.6±11.81 vs. 95.04±11.29 microns, respectively; P<0.001). Both patient groups had lower mean RNFL thickness as compared to the control group (105.83±8.32 microns; P<0.001). The greatest difference was observed in the inferior quadrant followed by the superior quadrant. Patients with unilateral ON demonstrated thinner RNFL (81.52±12.31 microns) in the affected eyes compared to the contralateral unaffected eyes (93.83±10.46 microns, P<0.001). Furthermore, patients with progressive MS had thinner RNFL compared to those with a relapsing remitting course, although the difference was not statistically significant (86.2±13.38 vs. 89.79±12.46 microns, respectively; P>0.05). Patients with the disease lasting between 1 and 5 years had thinner RNFL than those with a duration less than one year (88.87±12.5 vs. 99.07±8.19 microns, respectively; P<0.05). RNFL thickness did not differ in patients with only one ON attack from those with multiple attacks (88.48±12.59 vs. 84.31±10.87 microns, respectively; P>0.05). Measuring RNFL can quantitatively provide an index of axonal damage in MS patients and estimate disease progression and subsequent disabilities.

Abstract The role of serum lipid profile in development of intracerebral hemorrhage (ICH). The main purpose of current study was to compare the serum level of total cholesterol (TC), low-density cholesterol (LDL-CH), high-density cholesterol (HDL-CH) and triglysrides (TG) between patients with ICH and matched healthy subjects. There were 116 patients with ICH and 116 patients with low back pain as control group contributed in this retrospective control case study. The serum level of TC, LDL-CH, HDL-CH and TG were compared between two groups utilizing independent samples t-testand Mann Whitney U test. The serum level of TC was the same between two groups (189±49 mmol/L v.s 178±49 mmol/L; p=0.256). The serum level of LDL-CH (113±32 mmol/L v.s 96±39 mmol/L; p=0.001) and HDL-CH (43±10 mmol/L v.s 38±41 mmol/L; p=0.0001) was significantly higher and TG (123±69 mmol/L v.s 144±70 mmol/L; p=0.003) was significantly lower in the ICH group compared with control group. Hypercholesterolemia, but not hypocholesterolemia, and increased serum level of TG are associated with increased risk of ICH. Based on the large controversies exist regarding the findings of previous studies, more studies are required to determine the role and mechanism of action of cholesterol and TG in increasing the risk of ICH.