فاطمه حلال خور

Covid-19 is considered a new disease across the globe. Physical activity reduces risk factors, and with anti-inflammatory and antioxidant properties, saffron is used as a traditional herbal medicine to treat cough and asthma. Therefore, the present study aimed to assess the effect of saffron supplementation and endurance training on the concentration of C-reactive protein, interleukin-8, and clinical symptoms in outpatients with COVID-19.

The present research was conducted based on a randomized, double-blind, four-group, pretest-posttest design. The statistical population of this research entailed all outpatients with COVID-19 referred to the health center of Keshkosrai. Among this population, 36 cases were randomly selected. The research hypotheses were evaluated using SPSS software at a significance level of P<0.05 using the statistical test of analysis of covariance (ANCOVA) and paired T-test.

The results of ANCOVA demonstrated that after adjusting the effect of baseline values, height, and body mass index, there was a statistically significant difference between the groups in terms of the mean change of interleukin-8, C-reactive protein, partial oxygen pressure (SpO2), and body temperature (P<0.05). That is, the type of intervention can markedly affect the change of interleukin-8, C-reactive protein, partial oxygen pressure, and body temperature.

As evidenced by the obtained results, it is possible to use saffron as an auxiliary therapeutic method, as well as regular sports activity, which helps to control pathogens, including COVID-19, by boosting the body's immunity.

Background and

Anti-cytokine considerations in covid-19 patients can play a significant role in preventing death, therefore, physical activity by reducing risk factors, as well as saffron with anti-inflammatory and antioxidant properties, are considered as anti-cytokine solutions. Therefore, the purpose of this research is to investigate the effect of saffron supplementation and endurance training on the concentration of interleukin-6, interleukin-10 and cysteine in outpatients with coronavirus.

The statistical population of this research is outpatients with coronavirus, 36 of whom were randomly selected. Cytokines and cysteine were measured using a special kit and ELISA method. The research hypotheses were checked using SPSS software at a significance level of P<0.05 using ANOVA test with repeated measurements with between-group factor.

The results showed that endurance activity and saffron supplementation caused a significant decrease in IL-6 levels and the ratio of interleukin 6 to interleukin 10 (P≥0.05). Also, endurance activity along with saffron supplementation caused a significant increase in serum L-cysteine concentration (P=0.035). The results showed that there is no interaction effect between the measurement stages and the group, as well as intra-group and inter-group differences in interleukin-10 variables (P=0.511).

The levels of IL-6 and IL-10 decrease due to saffron supplementation and endurance training, and the amount of cysteine increases, which helps the recovery of covid-19 patients.

Exercise training with blood flow restrictionare associated with immunological changes as well as changes in the indices of inflammation and muscle damage. Therefore, the aim of this study was conducted to identify the effect of 4 weeks rock climbing with and without blood flow restriction on response of the LDH, CK and CRP in elite rock climbers.

12 elite male and 12 female rock climbers with at least 4 years rock climbing experience and age range of 23.54±2.32 to 27.18±3.18 years and a fat percentage of 8.22±1.12 to 14.19±1.18 percent were selected purposefully among elite climbers and randomly assigned to one of two groups The exercises were limited by blood flow and exercise without limitation of blood flow. The exercise protocol was performed for 4 weeks (three sessions per week and each session was 90 minutes, severity of each session was 60 to 80% of climbing grades). Blood samples were taken in two stages (pre and post test) in sitting and resting conditions to determine the amount of lactate dehydrogenase, creatine kinase, blood lactate and C-reactive protein. To analyze the data, an independent test was used to compare the meanings and Kolmogorov-Smirnov test for homogeneity of the two groups at a significant level of α ≤0.05.

The results showed that the index of muscle damage of LDH, CK and inflammatory CRP index did not show a significant difference in response to climbing exercises with and without blood flow restriction between the two groups (P <0.05).

According to the results of this study, rock climbing training with or without blood flow restriction, do not increase inflammatory and muscular damage, and this method of training is likely to be safe for climbers due to the mechanical and metabolic pressure of exercise activity.

Obesity is associated with increased oxidative stress. In addition, exercise can increase oxidative stress effects. However, the use of dietary supplements may moderate these indices. The present study is conducted to assess the effect of flaxseed supplementation on the total antioxidant capacity and lipid peroxidation after four weeks concurrent training in overweight women. Thirty six overweight women with BMI> 25 were randomly divided into four groups of 9 people, including supplementary training, concurrent training, supplementation flaxseed and control. All written consent was taken. Concurrent training included aerobic exercises with an intensity of 65% of heart rate and resistance training with intensity of 60% 1RM In between the Flaxseed powder (0.62 g per kg of body weight per day) was supplemented during the four-week period. Hypothesis research at the level of significance P <0.05 was used to analyze the variance (ANOVA) with repeated measurements with inter-group factor. The results showed that the concentration of malondialdehyde biomarker in the non-flax seed group increased significantly after the concurrent training (P <0.05). However, the total antioxidant capacity of plasma was not significantly different (P> 0.05). The results of this study indicated that acute concurrent Physical activity give rise to increased MDA concentration in overweight women. The application of flaxseed extract employed as an antioxidant supplement might ameliorate this marker and prevent the oxidative stress damage.

Regular sports exercises and the use of food strategies are always considered as low-risk and healthy approaches for coping and treatment of obesity. In this regard, the present study was performed with aim to determine the effect of concurrent training with Flaxseed supplementation on body mass index, glucose, insulin and insulin resistance in overweight girls. This clinical trial was performed on 36 overweight women in Tabriz University in 2017. The subjects were randomly divided into four groups (n=9 in each group), including training along with supplementation, concurrent training, supplementation Flaxseed and control. Concurrent training included aerobic exercises with an intensity of 65% of heart rate and resistance training with intensity of 60% 1RM. The subjects used the powdered seed one hour before food, at three meals and dissolved in 250 mg of water, during four weeks of supplementation course. Insulin value was measured using an ELISA kit, fasting glucose level by autoanalyzer, and insulin resistance by homoeostasis model (HOMA). Data was analyzed by SPSS software (version 22) and ANOVA, repeated measurements variance analysis, and bonferroni post hoc. P <0.05 was considered statistically significant. In concurrent training group, after four weeks, there was a significant decrease in WHR (P=0.015), and supplementation of flax seed alone caused a significant reduction in weight (P=0.008), fat percentage (P=0.041), WHR (P=0.015). Meanwhile, interventions could not affect insulin (P=0.511), insulin resistance (P=0.549), and glucose (P = 0.600). Four weeks of concurrent training and Flaxseed supplementation had no significant effects on glucose and insulin-related indices, and body composition. The use of such independent variables requires more research