دکتر اسکندر تقی زاده

Angiogenesis is a process in which new blood vessels produced from old vessels and this process plays an important role in the natural processes in body. Also, angiogenesis in tumor cells leads to further growth of these cells and leads to their metastasis. This process involves migration, proliferation and differentiation of endothelial cells. One of the new ideas that attracted the attention of scientists is to inhibit the angiogenesis process in cancer patients. Scientists are hoping that this method leading to a tumor cells therapy. The purpose of this study was to review the role of angiogenesis in metastasis of tumor cells with a therapeutic approach.

recurrent miscarriage is defined as accruing of at least 3 clinical spontaneous abortions or more. Several factors including genetic and environmental factors are involved in it. Among them, sulftase1 gene rs2623047 has a role in the human embryonic development. The purpose of this study was to evaluate sulftase1 gene rs2623047 polymorphism in women with recurrent abortions referred to the infertility center of Yazd, Iran. In the present case-control study, sixty-five healthy women were selected as controls and thirty-five women with recurrent miscarriage were included as cases. Blood samples were taken from both groups manually, using a low-salt DNA extraction and amplified fragment polymorphism rs2623047 1 sulfatase gene made by PCR and enzymic digestion conducted using BstNI enzyme. Results were analyzed using the chi-square test. GG genotype in cases were 42±9% and in control group 5/18% respectively (p=0.003). While the AG genotype in the control group was 9.56% and in the cases 1.37% (p=0.003). Genetic variation in sulfatase 1 gene may have a role in embryonic development during pregnancy and larger studies with more samples along with other polymorphisms in this gene may be helpful.