فهرست مطالب f. kazemi nasab

Several studies have investigated the effect of creatine supplementation on indirect markers of muscular damage and sports performance of athletes. However, pooled data from several studies suggest that the benefits of creatine on recovery of athletes are limited. The aim of this study was to investigate the effect of creatine supplementation on post-exercise recovery and muscle injury factors in healthy subjects.

A systematic search of articles published in English and Persian databases until November 2023 was conducted to investigate the effect of creatine supplementation on muscle injury markers creatine kinase (CK) and lactate dehydrogenase (LDH) and muscle soreness in healthy subjects. Weighted mean difference (WMD) and standardized mean difference (SMD) and 95% confidence interval were calculated using random effect model.

A total of 20 studies including 458 subjects were included in the present meta-analysis. The results showed that creatine did not cause a significant change in muscle soreness in any of 24, 48, 72, and 96 hours after exercise compared to the control group. Also, creatine did not cause a significant change in CK in any time spectrum compared to the control group. In addition, creatine did not cause a significant change in LDH in different time ranges after exercise compared to the control group in athletes and non-athletes.

The results of the present study show that creatine supplementation is not effective in reducing muscle soreness and muscle injury factors after exercise.

Polycystic Ovary Syndrome (PCOS) is linked to various cardiometabolic risk factors, including obesity, metabolic syndrome, hypertension, and low cardiorespiratory fitness. This study aimed to examine the impact of exercise training on serum lipid profile and blood pressure in women diagnosed with PCOS.

A systematic search was conducted in PubMed, Web of Science, SID, Magiran, and Google Scholar databases to extract English and Persian articles published until September 2022. Meta-analysis was performed to examine the effect of exercise training on serum triglyceride, total cholesterol, low-density lipoprotein (LDL), high-density lipoprotein (HDL), systolic blood pressure (SBP), and diastolic blood pressure (DBP) in women with PCOS. The standardized mean differences (SMD) or weighted mean differences (WMD) and 95% confidence interval (CI) were calculated using a random effects model. Heterogeneity was assessed using the I2 test, and publication bias was evaluated using a funnel plot and Egger's test.

The results of a meta-analysis comprising 20 studies involving 1242 patients with PCOS demonstrated that exercise training significantly reduced serum total cholesterol [SMD=-0.3, (CI: -0.47 to -0.12), p=0.001], serum LDL [SMD=-0.26, (CI: -0.44 to -0.09), p=0.003], and SBP [WMD=-3.12, (CI: -4.52 to -1.73), p=0.001] in women with PCOS compared to the control group. However, exercise training did not result in a significant decrease in serum triglycerides [SMD=-0.12, (CI: -0.31 to 0.06), p=0.2], serum HDL [SMD=0.06, (CI: -0.14 to 0.26), p=0.5], and DBP [WMD=-0.82, (CI: -2.04 to 0.39), p=0.1] in women with PCOS compared to the control group.

The findings of this study indicate that exercise training leads to a reduction in certain cardiometabolic risk factors, including total serum cholesterol, LDL, and systolic blood pressure (SBP) in women with PCOS. Therefore, exercise training is suggested as a non-pharmacological approach to mitigate the risk of cardiovascular complications for women with PCOS.